Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.

A method includes inserting a flexible cannula between a sclera and a choroid of an eye. The needle is advanced from a distal end of the flexible cannula, such that the needle pierces the choroid to access a subretinal space of the eye. The needle is used to aspirate fluid from the subretinal space. The fluid may be present from a retinal detachment, a macular hemorrhage, or other condition present before the procedure begins. The method may further include injecting the fluid in the subretinal space via the needle, in which case the fluid may be a balanced salt solution or other bleb fluid. The method may further include injecting a therapeutic agent into the subretinal space after aspirating the bleb fluid. The volume of injected bleb fluid may be greater than the volume of injected therapeutic agent.

An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, and an automated actuation assembly. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis that is obliquely oriented relative to the longitudinal axis of the cannula. The cannula may be inserted through a sclerotomy to position a distal end of the cannula at a posterior region of the eye, between the choroid and sclera. The needle may be advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer, adjacent to the area of geographic atrophy.

An eyewash dispensing container to store and deliver an eyewash fluid that is particularly suitable for terminal sterilization. The container includes a base and a locking lid with a tamper indicator. The container is able to be opened quickly and deliver the eyewash fluid directly to an eye of a user.

Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on a removable injector attachment or on a portion of the injection device housing. Other devices may include a filter for the removal of air, infectious agents, and/or other particulate matter from the composition before the composition is injected into the eye. Related methods and systems comprising the devices are also described.

An aid for dispensing eye drops to improve adherence. The aid, which may be integrated into an eye drop bottle (10) or be separately attached, aligns the eye drop container to better dispense eye drops, while resting the engagement surface (55) of an alignment structure (50) upon the bridge of a user's nose (80), supporting the eye drop container and not intruding upon the temporal half of the field of view of the user's eye.

A droplet dispensing assembly includes a spray-to-droplet converter attachment, a cross wall, and a spray delivery tube. The converter attachment is a tubular wall with a passageway between its front and rear ends. The cross wall is disposed in the passageway, spaced from the tubular wall front and rear ends, and extends in a transverse relationship to, and connected with, the tubular wall to define an obstruction in a path of liquid travel through the passageway from the rear end to the front end such that liquid spray impacts the obstruction and converts into liquid droplets that are dispensed from the front end. The spray delivery tube has an exit end mated with the tubular wall upstream of the cross wall relative to the path of liquid travel through the passageway.

A cartridge of an intraocular lens (IOL) inserter includes an insertion nozzle, having a distal insertion channel; an IOL-folding stage, having a proximal insertion channel; and a haptic protection structure to protect a trailing haptic of the IOL from damage by a push-rod of the inserter. The haptic protection structure includes a proximal guiding groove in the IOL-folding stage, or a distal guiding groove in the insertion nozzle. The haptic protection structure further includes a trailing-haptic notch, to guide a trailing haptic protruding from the proximal guiding groove; and a trailing-haptic retainer, to secure the trailing haptic out of the proximal insertion channel. An intraocular lens inserter includes an inserter cylinder; a push-rod in the inserter cylinder; a cartridge-receiving insertion tip, to receive a cartridge that includes an insertion nozzle, having a distal insertion channel; an intra-ocular lens-folding stage, having a proximal insertion channel; and a haptic protection structure.

A device for treating eyes, eyelids or both, in the form of a handheld housing is disclosed herein. The device has a first chamber configured as a fluid reservoir, a second chamber opened on a top end of a housing and configured as a steam reservoir, a hydrophilic material disposed within the first chamber, the hydrophilic material having a plurality of pours configured to allow the fluid to seep from the first chamber to the hydrophilic material, a heating element positioned adjacent hydrophilic material and the second chamber, the heating element configured to convert the liquid to a vapor and continuously regulate a temperature of the steam and a user interface disposed on an outside of the housing and configured to control a variable circulator, the variable circulator being positioned in an orifice at the top end of the housing, the variable circulator functioning to control the temperature of the vapor reaching the user. A method for treating eyes, eyelids, or both is also disclosed.