A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea.

A first image of the eye is generated when the cornea of the eye is exposed to a gas. The cornea is covered with an optic of a patient interface. A second image of the eye with the patient interface over the cornea is generated. In this second image, the patient interface distorts the second image of the eye. One or more of a position or an orientation of the eye is determined in response to the first image and the second image when the patient interface has been placed over the cornea.

A device for applying a marking to the human eye, in particular to the cornea of the eye, comprises a marking head comprising a marking element and a holding device carrying the marking head or an intermediate adapter. The marking head or the intermediate adapter has a bearing area which is rotatably mounted in a bearing ring of the holding device which surrounds the bearing area in a predeterminable or variable angular position.

A patient-specific finite element model of the cornea is generated for the purposes of modeling a cornea for simulating tissue cuts in the cornea. A first group of tissue fibers, with main fibers that extend parallel to the surface of the cornea, is distributed in the finite element model in accordance with a first distribution function. Moreover, a second group of tissue fibers, with inclined cross-linked fibers that do not extend parallel to the surface of the cornea, is distributed in the finite element model in accordance with a second distribution function. Here, the second distribution function distributes the cross-linked fibers with a non-uniform weighting function over the depth of the cornea, from the outer surface of the cornea to the inner surface of the cornea.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

A contact lens for corrective corneal crosslinking has a lens part and reservoir part. The lens part is constituted of a UV transmitting material, and provided, on a side thereof being in contact with the cornea of a patient's eyeball, with a pressing region configured to project in a convexly curved shape at a position for pressing the corneal dome center, and a relief region including an annular concave part whose cross section has a concavely circular arc shape that surrounds the pressing region's outer circumference. The reservoir part is disposed seamlessly and integrally therewith on the lens' outer side in a thickness direction in the pressing region, the reservoir part is provided with a communication hole for communication between the inside of the reservoir part and the pressing region, and a working electrode that has the same polarity as that of the riboflavin solution in the reservoir part.

A contact lens for corrective corneal crosslinking has a lens part and reservoir part. The lens part is constituted of a UV transmitting material, and provided, on a side thereof being in contact with the cornea of a patient's eyeball, with a pressing region configured to project in a convexly curved shape at a position for pressing the corneal dome center, and a relief region including an annular concave part whose cross section has a concavely circular arc shape that surrounds the pressing region's outer circumference. The reservoir part is disposed seamlessly and integrally therewith on the lens' outer side in a thickness direction in the pressing region, the reservoir part is provided with a communication hole for communication between the inside of the reservoir part and the pressing region, and a working electrode that has the same polarity as that of the riboflavin solution in the reservoir part.