The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).

Devices, kits and tools that facilitate pre-loading, storage, transportation and small incision, partial thickness corneal replacement procedures, including deep lamellar endothelial keratoplasty (DLEK), Descemet's stripping endothelial keratoplasty (DSEK) and Descemet's stripping automated endothelial keratoplasty (DSAEK), using donor eye tissue are provided.

Devices, kits and tools that facilitate pre-loading, storage, transportation and small incision, partial thickness corneal replacement procedures, including deep lamellar endothelial keratoplasty (DLEK), Descemet's stripping endothelial keratoplasty (DSEK) and Descemet's stripping automated endothelial keratoplasty (DSAEK), using donor eye tissue are provided.

A device for holding and aligning a trephine blade includes an elongated cylindrical component, a first alignment structure and a second alignment structure. The elongated cylindrical component extends along a first axis and comprises a hollow cylinder having an open proximal end, an open distal end, an inner cylindrical surface and an outer cylindrical surface. The first alignment structure is integral and co-planar with the proximal end and comprises a first circle attached to the inner cylindrical surface with one or more radially extending rods. The second alignment structure is arranged parallel to the first alignment structure within the hollow cylinder above the distal end and comprises a second circle attached to the inner cylindrical surface with one or more radially extending rods. The first and second circles are coaxial with the first axis and the first circle comprises a diameter that is greater than a diameter of the second circle.

Zero parallax visual axis glasses for corneal pre-marking include a target light, an alignment light, a polarized lens and a short pass filter. In some embodiments the targeting light and/or alignment light are LEDs and/or configured to blink. In some embodiments the target light is red. In certain embodiments the alignment light is white. The polarized lens can be placed on a user's non-dominant eye and block light originating from the target light and/or alignment light. The short pass filter can be configured to allow light from the target light to only pass through in one direction.

A corneal marking system, and methods for its use, has a tilt-detecting device attached to a corneal marker, adapted to produce a signal when the corneal marker is in a horizontal position. Use of measurement devices may be coordinated between the marker and a level-measuring device positioned on a patient's head. Devices capable of measuring one, two or three axes are used and processors are provided to evaluate the data produced by the devices and provide a physician with a signal that the positions of the patient's head and the marker are such that an accurate marking procedure can be performed.

Ultra-short pulsed laser radiation is applied to a patient's eye to create a row of bubbles oriented perpendicular to the axis of vision. The row of bubbles leads to a region of the eye to be ablated. In a second step, a femtosecond laser beam guided through the row of bubbles converts it to a channel perpendicular to the axis of vision. In a third step, a femtosecond laser beam is guided through the channel to ablate a portion of the eye. Using a femtosecond laser with intensity in the range of 10.sup.11-10.sup.15 W/cm.sup.2 for the second and third steps facilitates multi-photon ablation that is practically devoid of eye tissue heating. Creating bubbles in the first step increases the speed of channel creation and channel diameter uniformity, thereby increasing the precision of the subsequent multi-photon ablation.

Zero parallax visual axis glasses for corneal pre-marking include a target light, an alignment light, a polarized lens and a short pass filter. In some embodiments the targeting light and/or alignment light are LEDs and/or configured to blink. In some embodiments the target light is red. In certain embodiments the alignment light is white. The polarized lens can be placed on a user's non-dominant eye and block light originating from the target light and/or alignment light. The short pass filter can be configured to allow light from the target light to only pass through in one direction.

Vitrectomy probes and methods related thereto are disclosed herein. The disclosure describes various example vitrectomy probes having a rotational helical cutter. An example helical cutter includes an outer cutter portion and an inner cutter portion received therewithin. The inner cutter portion is operable to rotationally reciprocate within the outer cutter portion about a longitudinal axis thereof. A helical shearing surface formed at a distal end of the inner cutter portion is operable to sever material entering the cutter via a port formed in the outer cutter portion.

An elongate electrode is supported between two arms and configured to flex and generate plasma to incise tissue. Each of the arms is configured to penetrate tissue with the electrode supported therebetween to form a pocket with an incision. Each arm may comprise a distal tip shaped to penetrate tissue, and an internal curved structure such as a track is shaped to allow the electrode to slide over the curved structure while the electrode is tensioned. The internal curved structure may comprise an electrically insulating material that provides electrical insulation to the tensioned sliding electrode. An opening formed in a lumen allows the electrode to extended between the curved structure and the exposed portion of the electrode suspended between the two arms. The separation distance between the two arms can be adjusted to vary an exposed length of the electrode to create a pocket incision of varying width.