Compounds which directly inhibit IRE-1 activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Compounds of the form ##STR00001##
In which Q is selected from CHNR.sup.12, W, CH.sub.2NHR.sup.13, CHO and CH(OR.sup.17).sub.2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

Compounds of the form ##STR00001##
In which Q is selected from CHNR.sup.12, W, CH.sub.2NHR.sup.13, CHO and CH(OR.sup.17).sub.2 capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer and formulations and methods of use of such compounds.

This invention provides compound having a structure of Formula I: ##STR00001## Uses of such compounds and compositions comprising the compounds as alkylating agent sensors.

This invention provides compound having a structure of Formula I: ##STR00001## Uses of such compounds and compositions comprising the compounds as alkylating agent sensors.

Compounds which directly inhibit IRE-1 activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Compounds which directly inhibit IRE-1 activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

The invention provides compounds and compositions that are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

Provided herein are methods of preparation of compound 101.

##STR00001##

Also provided are intermediate compounds useful in the preparation of compound 101, and methods of preparation of those intermediate compounds.