The invention discloses a special-purpose reactive disperse dye for waterless dyeing of natural fibers in supercritical CO.sub.2 fluid and an intermediate thereof. The reactive disperse dye has a longer alkane-chain bridging group between a chromophoric parent structure and an active group of the dye, which effectively promotes the donating-withdrawing effect on the electron cloud in the conjugated system, enhances the hyperchromic effect, effectively reduce the influence of the active group itself and its reaction on the dye coloring system, improves the color and stability against acid and alkali of the dye, and facilitate the improvement of the compatibility of the dye with supercritical fluid and the dyeing performance for natural fibers as well. The invention also discloses an intermediate of the reactive disperse dye, and a method for preparing the reactive disperse dye.

Use of 2,4-dihalo-6-substituted-1,3,5-triazines as condensing, cross-linking, tanning, grafting, curing agents for the production of amides, esters, thioesters, and stabilized collagen and leather, CMC (carboxymethyl cellulose), synthetic and natural polymers. The process enables to obtain non-toxic and totally free of heavy metals products characterized by Tg values between 80° C. and 100° C.

The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).

The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).

The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia).

The present invention provides a novel P2X.sub.3 and/or P2X.sub.2/3 receptor antagonist. A compound represented by the formula (I): ##STR00001##
wherein R.sup.a, R.sup.b and R.sup.c are, (a) R.sup.a and R.sup.b are taken together Z; and R.sup.c is a group represented by R.sup.1c; or (b) R.sup.b and R.sup.c are taken together to form a bond; and R.sup.a is a group represented by YR.sup.1a; R.sup.1a and R.sup.1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R.sup.2 and R.sup.3 are each independently substituted or unsubstituted aryl, etc.; R.sup.4a and R.sup.4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is N(R.sup.5), etc.; R.sup.5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; Y is O, etc.; Z is O, etc.; and n is an integer of 0 to 4.

The present invention provides a novel P2X.sub.3 and/or P2X.sub.2/3 receptor antagonist. A compound represented by the formula (I): ##STR00001##
wherein R.sup.a, R.sup.b and R.sup.c are, (a) R.sup.a and R.sup.b are taken together Z; and R.sup.c is a group represented by R.sup.1c; or (b) R.sup.b and R.sup.c are taken together to form a bond; and R.sup.a is a group represented by YR.sup.1a; R.sup.1a and R.sup.1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R.sup.2 and R.sup.3 are each independently substituted or unsubstituted aryl, etc.; R.sup.4a and R.sup.4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is N(R.sup.5), etc.; R.sup.5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; Y is O, etc.; Z is O, etc.; and n is an integer of 0 to 4.

The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia). ##STR00001##

The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I) or (Ia). ##STR00001##

A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently NR.sub.4or O, R.sub.4 is hydrogen or C.sub.1-6-alkyl; R.sub.1 is hydroxy, C.sub.1-6-alkyl, C.sub.1-6-alkoxy, carboxy, C.sub.1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C.sub.1-6-alkylamino, or di-C.sub.1-6-alkylamino, the C.sub.1-6-alkyl or -alkoxy residue being optionally substituted with one or more R.sub.5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R.sub.2 is hydrogen, aryl, heteroaryl, or C.sub.1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R.sub.1 substituents, and where the C.sub.1-6-alkyl is optionally further substituted with one or more R.sub.5 substituents; and R.sub.3 is selected from hydrogen, halo, NR.sub.4R.sub.7, OR.sub.7, SR.sub.7, and R.sub.7, where the same options apply for R.sub.7 as for R.sub.2; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.