Cardiac valve repair devices and associated systems and methods are disclosed herein. A cardiac valve repair device configured in accordance with embodiments of the present technology can include, for example, a coaptation member and an atrial-fixation member. The coaptation member can comprise an inner portion having a coaptation surface configured to coapt with a first native leaflet during systole and an outer portion configured to displace at least a portion of a second native leaflet. The atrial-fixation member can comprise a plurality of interconnected struts having a circumferential U-like shape about a flow axis of the cardiac valve and defining a brim portion and a pair of connection portions. The connection portions can be coupled to the coaptation member, and the brim portion can be configured to press against cardiac tissue above the first native leaflet proximate to a native valve annulus of the cardiac valve.

Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve may be radially collapsible to a collapsed configuration and radially expandable to an expanded configuration. The prosthetic valve may comprise an annular frame, a leaflet structure positioned within the frame and a plurality of outer skirts positioned around an outer surface of the frame, each outer skirt comprising an inflow edge secured to the frame and an outflow edge secured at intervals to the frame. The plurality of outer skirts may include a first outer skirt and a second outer skirt, wherein in the expanded configuration the first and second outer skirts include openings unsecured to the frame between the intervals. The inflow edge of the first annular outer skirt may be secured to the frame with sutures including radiopaque material. The first annular outer skirt may include radiopaque dye.

A prosthetic heart valve for replacing a native atrioventricular valve may include a self-expanding stent formed as a monolithic structure. The stent may include an atrial disk, a ventricular disk, and a center portion extending between the atrial disk and the ventricular disk. A plurality of prosthetic leaflets may be directly coupled to the center portion of the stent. An outer fabric may be coupled to the stent. In an implanted condition of the prosthetic heart valve, the atrial disk is sized to contact an atrial side of the native atrioventricular valve, the ventricular disk is sized to contact a ventricular side of the native atrioventricular valve, the center portion is sized to be positioned radially inside the native atrioventricular valve without pressing against the native atrioventricular valve, and the outer fabric is configured to directly contact the native atrioventricular valve.

A prosthetic heart valve includes a stent body and prosthetic leaflets. The stent body extends from an inflow end to an outflow end and includes an annulus section defining a first row of cells extending in a circumferential direction, the stent body being expandable from a delivery condition having a first diameter to a deployed condition having a second diameter larger than the first diameter. The prosthetic leaflets are mounted to the stent body allow flow in an antegrade direction but substantially block flow in a retrograde direction. The first row of cells is circumferentially continuous in the delivery condition and in the deployed condition, and the stent body is further expandable from the deployed condition to an open condition in which the first row of cells is circumferentially discontinuous.

An orientable intravascular device having a “twelve o'clock” marker on a proximal and distal end for treating an aneurysm, including a packaging catheter with an identical fixed non-round shaped inner lumen, a pusher wire having an occlusion device releasably disposed on the distal end of said pusher wire, preloaded at a fixed circumferential orientation, with corresponding markers on the outside of said packaging catheter, a hub having an inner lumen that is shaped to marry with the outer lumen of the packaging catheter to deliver a delivery wire and occlusion stent in a predicted orientation, and maintaining such orientation as the wire and stent are advanced through said delivery catheter, and while said delivery catheter is withdrawn. Methods of using same are disclosed.

A venous valve prosthesis for transporting a flow of body fluid in a vessel in a predetermined direction includes

includes a hollow-cylindrical support structure. A skirt is connected to the support structure and forms a closed, circumferential jacket of the support structure. The prosthesis also includes a valve leaflet arrangement with a first valve leaflet and a second valve leaflet, each being connected to the skirt. A downstream edge of the first valve leaflet and a downstream edge of the second valve leaflet are opposite to each other and configured in such a manner that in a first state of the valve leaflet arrangement they form an opening for blood to flow through in the predetermined direction and in a second state of the valve leaflet arrangement the opening is closed and to prevent a backflow of blood in a direction opposite to the predetermined direction. A ratio of the inner diameter of the support structure to its length in the predetermined direction is at most 1.

The disclosure relates to a stent with a compressible and expandable mesh structure of webs which are interconnected by web connectors into one piece and define rhomboid cells, wherein each cell is defined by two straight webs and two S-shaped curved webs which connect the straight webs together, and wherein (i) in a non-operational state, the mesh structure has a fully expanded non-operational diameter Dexp which is between 3.0 mm and 5.0 mm, (ii) a ratio between a fully compressed diameter Dkomp of the mesh structure and the non-operational diameter Dexp of the mesh structure is between 1:7 and 1:12, and (iii) the webs have a web height, measured in a radial direction, which is at least 0.05 mm and at most 0.09 mm, so that the mesh structure has a radial force of at least 0.5 N, in particular at least 0.6 N, between the fully compressed diameter Dkomp and an operational diameter which is at most 90% of the non-operational diameter Dexp.

Disclosed are embodiments of replacement heart valves. Embodiments may include a collapsible and expandable frame comprising rows of cells. The frame may include a plurality of axial connection portions extending between top ends and bottom ends of the cells, wherein each axial connecting portion is shaped to bend for accommodating temporary changes in cell height during non-uniform compression of the replacement heart valve. Frames having these features are advantageous when advancing a replacement heart valve through a funnel-shaped compression tool. The axial connection portions are sufficiently flexible to accommodate changes in frame shapes during compression while also being sufficiently resilient for enhancing the structural integrity of the frame in the fully deployed state. The replacement heart valves are preferably dual-frame heart valves, wherein the axial connection portions form a portion of an inner frame and wherein an outer frame is provided for engaging tissue and forming a seal.

An intraluminal support structure having a delivery configuration that is a crimped open configuration to increase flexibility while maneuvering in the anatomy and having a small scarring signature.

The invention relates to a self-expendable stent for placement at a mitral annulus that is self-expandable from an undeployed state to a deployed state comprising a stent frame having at least a first section and a second section arranged at a longitudinal axis of the stent, wherein the stent frame is formed by a plurality of endless arms, the arms being connected to one another at connection points forming a web-like structure with diamond-shaped cells; a dry valve made out of bovine pericardium arranged at least at the second section of the stent with the dry bovine pericardium being configured to be rehydrated with a solution, a skirt surrounding the dry valve and comprising at least one of bovine pericardium and polyester, and wherein, in the expanded state, a maximum outer diameter of the first section is larger than a maximum outer diameter of the second section, and wherein at least at a transition between the first section and the second section some of the endless arms extend outwardly beyond the web-like structure to form a hook, which faces the first section.