A voice prosthesis for mounting in a fistula between trachea and esophagus is provided. The voice prosthesis comprises a tubular body having a lumen, a valve disc and a valve seat. The valve disc and a valve seat are arranged in the lumen of the tubular body, such that the valve disc and the valve seat control the connection through the lumen by interaction between the valve disc and the valve seat. A sealing rim is arranged between the valve disc and the valve seat, such that the interaction between the valve disc and the valve seat is obtained via the rim. A method for manufacturing a voice prosthesis is also provided.

Medical devices suitable for implantation in spaces between bones are described. An example medical device suitable for use as an intervertebral spacer includes a main body having an exterior proximal wall, an exterior distal wall, a first exterior lateral wall, a second exterior lateral wall, an upper surface, a lower surface, an interior proximal wall, an interior distal wall, a first interior lateral wall, a second interior lateral wall, and a longitudinal axis. The interior proximal wall, the interior distal wall, the first interior lateral wall, and the second interior lateral wall cooperatively define an interior cavity. The first and second exterior lateral walls are outwardly directed at an angle from the lower surface to the upper surface relative to the longitudinal axis.

Systems and methods are described for correcting sagittal imbalance in a spine including instruments for performing the controlled release of the anterior longitudinal ligament through a lateral access corridor and hyper-lordotic lateral implants with detachable fixation tabs.

Devices, systems, and methods for treating pulmonary disease are disclosed herein. According to some embodiments, the present technology includes identifying diseased tissue on a lobe of the patient's lung, collapsing the lobe, and percutaneously inserting a device into the patient and a therapeutic element carried by the device. The present technology further includes thoracoscopically delivering the therapeutic element into the patient's chest cavity, administering the therapeutic element on and around at least the diseased tissue, and applying an atraumatic compressive load to and/or restricting expansion of at least a portion of the diseased tissue.

An orthopedic device includes a lateral wedge positionable under a foot of a user. The lateral wedge has posterior and anterior ends, and upper and lower surfaces. First and second sides extend between the upper and lower surfaces. A thickness is defined between the upper and lower surfaces that tapers from the first side toward the second side such that the lateral wedge provides a lift under the foot to unload pressure from an affected compartment of the knee by supporting a one side of the foot in an elevated position relative to the other. At least one trim line extends in a direction between the posterior and anterior ends. The lateral wedge is trimmable along the at least one trim line to vary or control the amount of lift provided by varying the thickness of the lateral wedge along the first side relative to the second side.

An implant having an adhesive structure comprising a planar surface having two sides and rectangular cuboid-based protrusions having pyramidal tips extending from at least one of said sides, optionally having a porous basic supporting structure, and methods of making and using such implants.

Provided in this disclosure are various composite grafts having a trabecular scaffold with voids defined in at least a portion of the scaffold and a biological component positioned in at least some of the voids of the scaffold. The grafts may have a synthetic scaffold or a bone substrate scaffold. The grafts may be osteogenic, chondrogenic, osteochondrogenic, or vulnerary in nature. Also provided are methods of using the composite grafts to treat a tissue defect in a subject. Methods of manufacturing are also provided. Synthetic scaffolds are manufactured by additive manufacturing. Agitation is used to combine the biological component with the scaffold of the graft.

This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

The present invention relates to a suturing thread for providing a more efficient lift procedure, and provides a suturing thread for a facelift and a body lift, wherein the suturing thread is made of a polymer material and has a plurality of conical protrusions or a plurality of funneled protrusions formed on an outer circumferential surface of a main thread of the suturing thread.

A prosthetic system that includes a prosthetic implant and a support structure secured to an inner surface of the cavity in the end of the bone is disclosed. The support structure defines a channel that extends through the length of the support structure. The prosthetic implant is received in the channel, and a portion of the prosthetic implant is secured to an inner surface of the channel by an adhesive. The stem of the prosthesis beyond the channel may be cemented or uncemented. The support structure may have an approximately funnel shape. The support structure may be a hollow porous cylindrical sleeve. The support structure may comprise a pair of partially hemispherical components arranged in spaced apart relationship thereby defining a channel between the pair of components. The support structure may comprise a plurality of pedestals secured to the inner surface of the cavity of the bone.