In some embodiments, a medical device delivery system includes a catheter and a retainer. The retainer can be engaged with the medical device to restrain relative movement of the medical device in one or more axial and/or radial directions. A variety of retainers and retainer systems are disclosed, many of which can reliably disengage the medical device from the retainer. Methods for using the medical device delivery system are also described.

A combined sheath with a wire body and a filter. The filter may be removably coupled to the sheath within a filter capsule for temporary placement and retrieval.

A venous valve prosthesis includes a frame and a prosthetic valve coupled to the frame. With the venous valve prosthesis implanted in a vein, the prosthetic valve includes a closed configuration wherein an outer surface of the prosthetic valve is in contact with a wall of the vein around a circumference of the prosthetic valve to prevent blood from flowing past the prosthetic valve between the wall of the vein and the outer surface of the prosthetic valve. The prosthetic valve is configured to move to an open configuration such that at least a portion of an outer wall of the prosthetic valve partially collapses away from the wall of the vein in response to antegrade blood flow through the vein to enable blood flow between the outer surface of the prosthetic valve and the wall of the vein.

An intravascular device for treating a cerebral aneurysm which has an externally controllable expandable member, the expandable member has a plurality of wires that define walls of the expandable member; where in a relaxed state of the expandable member the walls have at least a first wall portion in which openings defined between the wires are small enough to prevent coils positioned within the aneurysm from exiting the aneurysm, the first wall portion comprising an axial length at least as long as a neck of the aneurysm; and at least a second wall portion in which openings defined between the wires are large enough to allow blood flow through; the second wall portion axially aligned relative to the first wall portion.

An embodiment includes a system comprising: first and second conduits respectively including first and second barbed rods; first and second shafts; wherein: (a)(i) in a first configuration the first shaft slides distally within the first conduit and couples to a proximal end of the first barbed rod, and (a)(ii) in a second configuration the first shaft slides distally within the first conduit and pushes the first barbed rod out of the first conduit; wherein: (a)(i) in an additional first configuration the second shaft slides distally within the second conduit and couples to a proximal end of the second barbed rod, and (a)(ii) in an additional second configuration the second shaft slides distally within the second conduit and pushes the second barbed rod out of the second conduit. Other embodiments are described.

Arcuate fixation members with varying configurations and/or features are provided, along with additional components for use therewith in provided fixation systems and intervertebral implant systems. The arcuate fixation members may be of varying lengths, cross sectional geometries, and/or cross sectional areas, and may be configured with various features such as heads configured to accept other fixation system components, tabs to allow arcuate fixation member-in-arcuate fixation member or fixation anchor-in-arcuate fixation member configurations. Applications of fixation systems and intervertebral implants systems utilizing arcuate fixation members are particularly suitable when a linear line-of-approach for delivering fixation members is undesirable.

An intravascular emboli capture and retrieval system for intravascular embolism protection and embolism removal or maceration. Guidewire mounted proximally and distally located multiple opening filters are deployed within the vasculature and used to part, divide and macerate embolic debris and to capture such embolic debris within the confines thereof. A deployable flexible preformed memory shaped capture sleeve is alternatively used to collapse one or more filters and embolic debris therein for subsequent proximal withdrawal from the vasculature.

A combined multi-lumen sheath with a wire body and a filter. The filter may be removably coupled to the multi-lumen sheath within a filter capsule for temporary placement and retrieval.

An intravascular device for treating a cerebral aneurysm which has an externally controllable expandable member, the expandable member has a plurality of wires that define walls of the expandable member; where in a relaxed state of the expandable member the walls have at least a first wall portion in which openings defined between the wires are small enough to prevent coils positioned within the aneurysm from exiting the aneurysm, the first wall portion comprising an axial length at least as long as a neck of the aneurysm; and at least a second wall portion in which openings defined between the wires are large enough to allow blood flow through; the second wall portion axially aligned relative to the first wall portion.

An embolic protection device including a porous deflector screen including a filter, arranged to expand and to conform to a wall of the aortic arch covering entrances to arteries branching from an aorta, an emboli collector including a cylinder arranged to expand and to lie along walls of a descending aorta, pushing against walls of the descending aorta and anchoring the porous deflector screen, and a connecting portion for connecting the porous deflector screen and the emboli collector, arranged to push the porous deflector screen against a wall of the aortic arch while anchoring against the emboli collector. Related apparatus and methods are also described.