Embodiments of the present disclosure are directed processes to produce a low-color esterified oil soluble polyalkylene glycol, the process comprising forming a reaction mixture including a low viscosity oil soluble polyalkylene glycol and an excess amount of valeric acid, where the reaction mixture is formed in the presence of a catalytic amount of ortho-phosphoric acid catalyst to yield an organic phase including the low-color esterified oil soluble polyalkylene glycol.

An amphiphilic polymer comprising: at least 10 wt-% monomeric units comprising alkylene oxide moieties, wherein a majority of the alkylene oxide moieties are ethylene oxide moieties; monomeric units comprising hexafluoropropylene oxide oligomeric moieties having the formula C.sub.3F.sub.7O—(CF(CF.sub.3)CF.sub.2O).sub.aCF(CF.sub.3)—C(O)N(H)-Q-, wherein Q is a linking group with at least one carbon atom, and “a” is at least 5; and monomeric units comprising pendant groups selected from phosphate groups, phosphonate groups, sulfonate groups, and combinations thereof; wherein the amphiphilic polymer is water dispersible; aqueous coating compositions containing the amphiphilic polymer; and methods of treating a hard surface.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

An amine functional compound comprising i. least one segment consisting of at least one ether unit E and at least one ester unit, wherein the ether units and ester units are connected by an ether link or by an ester link, and wherein the sum of the number of ether units and ester units is at least three, and wherein the ether units and ester units are arranged in random order, and ii. at least one amine group ii. selected from a tertiary amine group, a salt of a tertiary amine group and a quaternary ammonium group, wherein the at least one segment is covalently linked to a polymerization starter moiety comprising the at least one amine group ii.

A process for preparing a low-molecular weight fluoropolyether containing an acid fluoride by decomposing a triflate or trifluoroacetate of a fluoropolyether having a hydroxyl group in the presence of a Lewis acid.

The invention provides methods and polymer-containing formulations for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (a) a nucleo-functional polymer is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R.sup.1—SH wherein R.sup.1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C.sub.1-C.sub.6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups. Formulations are provided containing a nucleo-functional polymer, a poly(ethylene glycol) polymer, and an aqueous pharmaceutically acceptable carrier, for use in the therapeutic methods.

A demulsifier includes the reaction product of a) alkoxylated castor oil, b) an acid having at least two carboxyl groups, a full or partial ester thereof, an anhydride thereof and combinations thereof, and optionally c) a fatty acid, a fatty acid ester and combinations thereof. A method of demulsifying a water-in-oil or oil-in-water emulsion includes adding the demulsifier to the emulsion and separating the emulsion into an oil phase and a water phase.

A novel multi-arm polyethylene glycol (PEG) (I) and preparation method thereof. Active derivatives (II) based on the multi-arm PEG. Gels formed of the active derivatives. Drug conjugates formed of the active derivatives and drug molecules and uses thereof in medical preparation. The multi-arm PEG is formed by polymerizing ethylene oxide with pentaerythritol oligomers as initiator, wherein PEG is the same or different and is a —(CH2CH2O)m-, the average value of m is an integer of 3-1000, l is an integer more than or equal to 2. An 8-arm PEG is preferred, wherein l is equal to 3. The active derivatives (II) comprise link groups X attached to PEG and active end groups F attached to X.

Methods of using a curable composition, the curable composition including at least one polyether having blocked hydroxyl groups as the plasticizer on at least one alkaline substrate. The curable composition is storage-stable, easy to handle and highly elastic after curing, and does not show any tendency to separate or migrate. It enables elastic bonding, sealing or coating of alkaline substrates, such as, in particular, fresh or green concrete or cement mortar, without occurrence of troublesome odors triggered by plasticizer hydrolysis.

The hydrophobic and corrosion resistive film of cross-linked poly(hexafluoroisopropyl methacrylate) was prepared by photopolymerization. The starting materials were a monomer of 1,1,1,3,3,3-hexafluoroisopropyl methacrylate, a photoinitiator of hydroxycyclohexyl phenyl ketone, and a cross-linker of poly(ethyleneglycol diacrylate). Photopolymerization was used to start polymerization and to cure the polymer film on an aluminum surface. Drop-casting was used to deposit the fluoropolymer onto an aluminum substrate (AA 3003). The fluoropolymer film has high corrosion protection when measured by potentiodynamic polarization and open circuit potential techniques in an aqueous solution of 3.5% NaCl. Fourier-transform infrared spectroscopy was used to monitor the polymerization process. The dynamic contact angle technique was used to measure the hydrophobicity for the fluorinated polymer coating. Thermal stability of the fluorinated polymer was measured using thermogravimetric analysis. Treatment with strong acid followed by contact angle measurements before and after the treatment confirmed the chemical resistance for the coated aluminum.