The present disclosure provides for a metal chelated polyol liquid and/or a metal chelated polyether polyol liquid that can be used in an isocyanate-reactive composition and a reaction mixture for forming a polyurethane polymer. The metal chelated polyester polyol liquid is a reaction product of a chelating polyester polyol having a chelating moiety and a metal compound having a metal ion. The metal chelated polyether polyol liquid is a reaction product of a chelating polyether polyol having a chelating moiety and a metal compound having a metal ion. The chelating moiety of the chelating polyester polyol or the chelating polyether polyol chelates the metal ion to form the metal chelated polyester polyol liquid or the metal chelated polyether polyol liquid, respectively, having a mole ratio of the metal ion to the chelating moiety of 0.05:1 to 2:1.

Compounds of formula I: or a pharmaceutically acceptable salt, hydrate, and/or solvate thereof, wherein: R.sub.1 is a pharmaceutically acceptable polymeric moiety comprising a pharmaceutically acceptable polymer chain such that the carbonyl group is linked to R.sub.1 through an ester, amide, carbonate or carbamate bond; R.sub.2 is hydrogen, or —(C═O)Rs wherein R.sub.5 is a C.sub.1-3 straight or branched chain alkyl group; and R.sub.3 and R.sub.4 are independently selected from hydrogen, C.sub.1-3 straight or branched chain alkyl group, or —(C=0)Re wherein R.sub.6 is —(O—CH.sub.2—CH.sub.2).sub.n—OCH.sub.3 or a C1-3 straight or branched chain alkyl group, and n is 1 to 5. The compositions are useful for the treatment of Parkinson's disease when administered alone or in combination with carbidopa and/or entacapone.

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A method for producing a fluoropolyether group-containing compound, which includes reacting a fluoropolyether group-containing compound (A) represented by the formula (1) with a compound (C) represented by any of the formulae (c1) to (c4) in the presence of a metal catalyst including at least one selected from Pd, Cu, Ni, Pt, and Ag. The symboles are as defined herein.

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Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol.

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

A composition for forming a resist underlayer film that functions as an anti-reflective coating during exposure and can be embedded in a recess having a narrow space and a high aspect ratio, and has excellent resistance to an aqueous hydrogen peroxide solution. A resist underlayer film-forming composition containing a resin, a compound of the following Formula (1a) or (1b): ##STR00001## wherein X is carbonyl group or methylene group, 1 and m are each independently an integer of 0 to 5 and satisfy a relational expression of 3≤1+m 10, and n is an integer of 2 to 5, and a solvent, wherein the compound of Formula (1a) or (1b) is contained in an amount of 0.01% by mass to 60% by mass relative to the amount of the resin.

The present invention provides a (poly)alkylene glycol-containing compound having higher detergency for composite stains of hydrophilic stains and hydrophobic stains than conventional (poly)alkylene glycol-containing compounds. The present invention relates to a (poly)alkylene glycol-containing compound including: a hydrophobic structural moiety (A); a (poly)alkylene glycol moiety (B); and one lactam ring-containing structural unit (C), in its structure, the hydrophobic structural moiety (A) being present in a proportion of 2.5 to 60% by mass in 100% by mass of the (poly)alkylene glycol-containing compound.

Provided herein is a process for preparing a heterocycle-functional polyoxyalkylene polyol, in which a polyoxyalkylene polyol having unsaturated groups is reacted with a heterocyclic compound. Also provided herein is a heterocycle-functional polyoxyalkylene polyol, a method of crosslinking a heterocycle-functional polyoxyalkylene polyol, a crosslinked, heterocycle-functional polyoxyalkylene polyol, and related processes.

A surface-treating agent including a perfluoro(poly)ether group-containing silane compound and a perfluoro(poly)ether group-containing compound. The perfluoro(poly)ether group-containing compound contains a radical capturing group or a UV absorbing group in the molecule.