A method comprising the steps of applying an adhesive composition to a substrate bone repair region. The adhesive composition comprises a porous, biocompatible, biodegradable, resorbable, non-toxic, and polymerizable composition. The substrate bone repair region comprises a bone structure, implant or device surface, or tooth surface. The adhesive composition is cured to provide a polymerized adhesive composition resulting in repairing or augmenting the substrate bone repair region. The adhesive composition may be mixed with a bone graft material before application. The adhesive composition may be additionally applied to a barrier membrane that is placed over the substrate bone repair region where the adhesive composition or combination of adhesive composition and bone graft material is applied.

An adjustable, knotless button/loop/needle construct for fixation of cranial cruciate ligament deficient stifle. The adjustable, knotless construct includes two fixation devices (for example, two buttons) and at least one flexible, adjustable loop attached to at least one of the fixation devices (e.g., the buttons). Preferably, a needle is attached to each of the fixation devices (e.g., the buttons). The adjustable, knotless construct has an adjustable loop length and allows adjustment in one direction while preventing or locking the construct from loosening in the opposite direction, due to applied tensile forces. The construct and technique of the present invention provides an improved knotless system for cruciate ligament repair.

A link (1) for connecting two loops of a flexible tension-carrying construct (2, 2a). It solves the problem of providing effective means to connect two anchor points (7, 7a), typically on bones articulating at a joint by the flexible tension-carrying construct.

Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic technique to configure the features and dimensions of the magnesium foil, and rolling the magnesium foil to form a cylinder.

A method for in-vivo cell replacement is disclosed. The method includes steps of extracting donor cells from a donor tissue of a patient; generating donor material including the donor cells; removing one or more cell layers from a receiver tissue of the patient to expose a target layer of the receiver tissue while maintaining operation of a vasculature of the receiver tissue; and printing the donor material onto the target layer of the receiver tissue. A tissue position assembly, a composition for use in a treatment of bladder damage or bladder dysmorphism, and a system for supplying donor material to a bioprinter are also disclosed.

The present invention provides a surgical treatment for a disordered knee in a dog, the disorder comprising a partially ruptured cranial cruciate ligament (CrCL), a fully ruptured CrCL, or a displaced patella. The methods of treatment include surgical transection of the tendon of the popliteal muscle, which reduces the in-toeing of the paw as it lands on the ground. In vitro experiments suggest that neutralization of this torque can reduce by several fold tensile forces in the CrCL or its replacement, as well as in its surrogate, a lateral suture placed extra-capsularly.

Methods and devices for draining intraocular fluid from an eye and treating glaucoma in humans or animals are provided. In some embodiments, the device has a scleral plate with a groove and/or locking mechanism and an extensible tube or tubes having at least one lumen. In some embodiments, the distal portion of the extensible tube has a terminal open end adapted to be placed in an intraocular chamber of an eye and configured to prevent extrusion of the terminal open end from the intraocular chamber following placement.

A method and implant to treat anterior cruciate ligament (ACL) injuries are disclosed. The method involves advancing the insertion of the patellar ligament to the proximal tibia. The implant includes a spacer (30) which is inserted between the patellar ligament and the tibia and fixed to the tibia. The spacer decreases the angle between the patellar ligament and the tibia plateau and consequently modifies the internal joint force, restoring stability to the joint even if the ACL is ruptured. The method and implants are applicable to both human and canine patients.

A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.