The present invention provides, among other things, apparatus and methods of use for treating a subject in need of assistance with breathing. In some embodiments the subject suffers from airflow obstruction. In some embodiments, the subject suffers from chronic obstructive pulmonary disease.

The non-invasive pulsatile circulatory support device intended to promote circulation of a blood volume in at least a part (Z) of a subject's body, the device including a flexible structure, arranged so as to be applied on at least the part of the subject's body, including a series of paired adjacent pouches extending along one another; and means for generating a physiologically synchronised pulsation fluidically connected to the flexible structure in a leak-tight manner and arranged so as to create pulsation waves in the series of pouches between the inner and outer layers, one of the paired adjacent pouches at least partially covering the other of the paired adjacent pouches (scaled structure).

A gastrointestinal treatment system including a gastrointestinal capsule adapted to treat a subject following ingestion of the gastrointestinal capsule. The gastrointestinal capsule includes: (a) a housing; (b) a vibrating agitator, powered by the battery, the vibrating agitator adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule; (c) a power supply disposed within the housing and adapted to power the vibrating agitator; and (d) a controller adapted, in response to receipt of an activation input, to activate the vibrating agitator to operate in the first vibrating mode of operation at at least one predetermined time of day. The system and method may be used to treat an ailment of the gastrointestinal tract and/or to mitigate at least one symptom of jetlag in a subject travelling from an origin location to a destination location.

The present invention relates to nanoparticles comprising nucleic acids coated with a (biodegradable) polymer for reversible immobilization and/or controlled release of the nucleic acid comprising nanoparticles. Furthermore, the present invention is directed to medical or diagnostic devices, particularly stents and implants coated by a (biodegradable) polymer with the nucleic acid comprising nanoparticles for reversible immobilization and/or controlled release. Furthermore, the present invention is directed to the use of these nanoparticles coated with a (biodegradable) polymer and to the use of medical devices and implants coated by the (biodegradable) polymer with these nucleic acid comprising nanoparticles in the prophylactic or therapeutic treatment of diseases, particularly in the prevention or treatment of restenosis, calicification, foreign body reaction, or inflammation. Additionally, the present invention is directed to a method of preparing these nucleic acid comprising nanoparticles coated with a (biodegradable) polymer and to a method for coating nucleic acid comprising nanoparticles by a (biodegradable) polymer on medical or diagnostic devices.

Systems and methods for an exercise apparatus are provided and include a flexible elongated member, a binding apparatus, and a motor assembly. The binding apparatus is attached to the flexible elongated member and has a clamping mechanism configured to secure a shoe of a user of the exercise apparatus to the flexible elongated member. The motor assembly is disposed between the shoe and the flexible elongated member and is configured to cause the flexible elongated member to oscillate.

Described herein are devices and methods used for providing comfort to an infant, and in particular, to devices and methods for introducing a therapy protocol to an infant in, for example, a neonatal intensive care unit.

An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.

This document describes automated abdominojugular reflux (AJR) testing. To automate AJR tests, a pressure cuff wrapped around a person's abdomen applies pressure while video of their neck is captured. By way of example, a medical professional wraps a pressure cuff around the person's abdomen and records video of the person's neck using a smartphone, which communicates with the pressure cuff to synchronize the application of pressure with video capture. The video is processed to detect and track the response of jugular venous pulse (JVP), which is compared to AJR test thresholds to determine test results. While determining JVP, and thereby results of AJR tests, from reconstructed videos may not result in data that is as accurate as invasive intra-heart tests, it requires little if any risk to patients and is easy for medical professionals to perform. Further, these techniques enable AJR tests to be performed automatically and without relying on estimates made by skilled medical professionals.

A method and apparatus that affect vacuum to massage a volume of the skin and one or more types of skin treatment energies coupled to the massaged volume to treat the skin and subcutaneous adipose tissue and produce a desired treatment effect. The method and apparatus are based on coupling an array or a number of arrays being an assembly of skin treatment units with each skin treatment unit including a hollow cavity and a number of different energy to skin applying elements operative to receive skin treatment energy from a source of such energy and couple or apply the received energy to a treated segment of skin.

An automated resuscitation system is provided, which can improve the outcome of patients suffering ventricular fibrillation or the ventricular tachycardia variants of cardiac arrest. This outcome can be achieved by a device that integrates automatic mechanical or pneumatic capability with electrical countershock capability such that the probability of defibrillation or cardioversion with return of spontaneous circulation is increased.