A disease management system including: a Diagnostic Module, which provides access to patient information and scientific guidelines for patient treatment; a Diagnostic Interpretive Module, which provides tools to evaluate risk of particular diseases or conditions based on patient information and an evaluative methodology; a Prescriptive Module, which is used to recommend, select, and/or evaluate one or more treatment regimens based on patient information and guidelines; a Dispensing Module, which evaluates a patient's compliance with a treatment regimen; and/or a Feedback and Patient Management Module, which gathers compliance information and evaluates efficacy of a treatment regimen for a patient. In embodiments of the subject invention, some or all of the modules described can communicate to manage a disease, medical condition, and/or health problem in a patient.

A tablet formed from a pre-lyophilization solution has a void in its bottom surface, with a void height that is about 60% to 100% of a depth of the tablet. A pharmaceutical dosage form includes a blister sheet having one or more cavities, each having a protrusion extending upwardly from the cavity floor, with a tablet formed in the cavity by lyophilization of a pre-lyophilization solution in each such cavity. The protrusion is a cylinder or tapered cylinder and the void has a corresponding shape. A film overlays the blister sheet to seal the tablet in the blister sheet cavities.

A multi-layer film structure for use in forming blister packaging. The multi-layer structure includes a first polymeric layer having a first surface and a second surface, the first polymeric layer comprising a metalized polyethylene teraphthalate, a second polymeric layer having a first surface and a second surface, the first surface of the second polymeric layer disposed adjacent the second surface of the first polymeric layer, the second polymeric layer comprising a cyclic olefin or a homopolymer of chlorotrifluoroethylene, and a third polymeric layer having a first surface and a second surface, the first surface of the third polymeric layer disposed adjacent the second surface of the second polymeric layer, the third polymeric layer comprising polypropylene or polyvinyl chloride. A method of making a multi-layer film structure and a packaging structure are also provided.

A blister pack having a backing having a first side and an opposing second side. Each of the first and second side is flat or planar. The blister pack can also include a cover having a first side and an opposing second side. At least a portion of the second side of the cover is adhered to the first side of the backing to form a sealed package for containing product. The cover can include at least one blister. The blister pack can also include an active member positioned within each blister. Each active member can be in the form of a ring with an opening extending therethrough or a depression formed therein.

A seal for use with a container for storing and dispensing consumer products is described. The seal includes a cover layer having pre-formed lines of separation defining one or more releasable portions, an adhesive layer on the cover layer, and one or more patches on the adhesive layer. Each patch is associated with a respective one of the releasable portions 6 and consists of a hot melt polymer. The hot melt polymer can be applied to the adhesive layer using a suitable coating or spraying process.

A pharmaceutical packaging composite film includes a heat sealing layer, an aluminum foil layer, and an impact resistant layer. The heat sealing layer contains residues derived from at least one of 1,4-butanediol, isophthalic acid, isoprene glycol, and isopropanol, and thus has a melting point between 130° C. and 180° C. The aluminum foil layer is disposed on the heat sealing layer. The impact resistant layer is disposed on the aluminum foil layer.

Embodiments are generally directed to systems and apparatuses for tracking usage of an item. For example, an apparatus may be provided for tracking use of a packetized item. The apparatus may include a microprocessor, a power source, and a structural layer to which the microprocessor and power source are coupled. The structural layer may include a container that is configured to hold various items. The container may also include an opening that allows access to the items. The apparatus may further include a cover layer that is configured to cover the opening of the container. The cover layer may include at least one bendable sensor placed over the opening of the container. The microprocessor may be configured to determine, using detected movements in the bendable sensor, whether the container has been opened.

The present disclosure enables apparatus and methods for tracking medications and/or product units via smart-packaging concepts. Embodiments include sensors that monitor the state of a blister-card package having an unpatterned lidding film by measuring the impedance of each dispensing region of the lidding film that defines a portion of a blister. In some embodiments, the impedance is measured via a plurality of contact points arranged on opposite sides of each dispensing region, where the contact points are resistively or capacitively coupled with the lidding film. In some embodiments, the impedance map of a measurement region on the blister card is derived via electrical impedance tomography or electrical resistance tomography, where the measurement region includes a plurality of dispensing regions.

An automatic blister card packager (200) is provided. The automatic blister card packager (200) includes a universal feed cassette (205) for individually dispensing medications, a packaging unit (210) in communication with the universal feed cassette (205). The packaging unit (210) is configured to receive a blister card (100). The automatic blister card packager 210 also includes a chute (230) connecting the universal feed cassette (205) to the packaging equipment (210). The chute (230) includes a plurality of tracks (450) and directs the medications dispensed from the universal feed cassette (205) into the blister card (100) received in the packaging equipment (210).

An example medical cabinet system disclosed herein includes a computing system that selectively enables access to a medication pack or other object based on a dispensing schedule, stores event data relating to operation of the cabinet system, and transmits that event data to a remote computing system over a communications network.