This disclosure provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units, wherein said capsule dosage form is bioequivalent to the marketed Toprol-XL tablet. The extended-release capsule dosage form comprising coated discrete units can be sprinkled onto food to ease administration to patients who have difficulty swallowing tablets or capsules.

The invention relates to a capsule comprising an inlet and an outlet connected by a passage, in which a dissolvable blocking element and a composition to be orally administered are arranged. The blocking element is fluid permeable and, in a non-dissolved condition, is arranged in the passage to block delivery of the composition to an outlet of the passage. The invention further relates to a method for releasable sealing a capsule comprising a composition to be orally administered, comprising the steps of providing the composition chamber in a passage and filling composition into the composition chamber. The passage formed by the capsule is occluded with a blocking element and the blocking element comprises dissolvable material and has a fluid permeable structure.

A compartmented hard shell capsule for containing active formulations, and methods and apparatuses for forming, filling and encapsulating the compartmented hard shell capsules. The compartmented hard shell capsule includes a cap portion and a body portion. The cap portion has a hollow cavity defining a cap chamber. The body portion can be removably inserted into the cap portion. The body portion has an open end, a closed end and a sidewall defining a hollow cavity and a serrated edge along the open end. The serrated edge may be folded over to form a barrier to enclose the body portion, thereby creating a body chamber that is separate from the cap chamber when the body portion is inserted into the cap portion. The methods for filling and encapsulating the compartmented hard shell capsules can be completed in one continuous process, which increases cost-effectiveness for use of the compartmented hard shell capsules.

Methods, systems and apparatuses are provided for producing delivery devices, preferably for oral intake of an agent. In the broadest aspect, the method comprises assembling one or more layers comprising one or more materials with an agent or an agent-releasing formulation to form an intergraded, preferably laminated device; folding said integrated delivery device to form a folded integrated delivery device; and at least partially enclosing said folded delivery device to a form suitable for oral delivery. Preferably, the integrated device comprise a first external layer of a first material; a frame of a second material mounted on the first external layer; an agent-releasing formulation housed within the frame; and a second external layer of the first material mounted on the frame.

This disclosure provides an extended-release capsule dosage form of metoprolol succinate in the form of coated discrete units, wherein said capsule dosage form is bioequivalent to the marketed ToprolXL tablet. The extended-release capsule dosage form comprising coated discrete units can be sprinkled onto food to ease administration to patients who have difficulty swallowing tablets or capsules.

The disclosure relates to a transfer device of a capsule filling machine for transferring at least one capsule from a capsule receptacle of a capsule segment to a downstream process station, and to a capsule filling machine having such a transfer device. The transfer device includes a transport segment having at least one transport receptacle, which extends along a vertical longitudinal axis, wherein the transport receptacle is configured as a clamping receptacle having a clamping element, acting radially with respect to the longitudinal axis of the transport receptacle, for the capsule.

Disclosed herein are coatings for an encapsulated gastric residence system. The coating includes 50-95 wt. % reverse-enteric polymer; 3-25 wt. % anti-tacking agent; and 1-20 wt. % plasticizer.

Provided are gastric residence dosage forms comprising: a gastric residence system in a folded configuration; a capsule encapsulating the gastric residence system in a folded configuration; and a coating on the capsule, wherein the gastric residence dosage form is configured to release the gastric residence system in a stomach of a patient, allowing the gastric residence system to assume an open configuration. The coating on the capsule includes a polymer, an anti-tacking agent, and/or a hydration aid.

A drum-type dosing apparatus is for producing individual dosing quantities of a pulverulent product. The drum-type dosing apparatus includes a product store which is arranged in a filling position, a dosing drum and also a rotary drive for the dosing drum. The dosing drum has circumferentially distributed dosing openings. At least two dosing openings spaced apart from one another in a circumferential direction of the dosing drum are combined to form a joint dosing portion. The rotary drive is configured for stepwise rotation of the dosing drum about an axis of rotation such that an individual dosing portion with the associated dosing openings ends up located, over the course of a cycle, at least in the filling position and in a discharging position.

A capsule filling machine (10) for filling a capsule, which has a capsule upper part and a capsule lower part, includes a conveying device (32), a filling station (82) and at least one station (86) for closing a filled capsule lower part with a capsule upper part and for transporting a filled capsule. The station comprises a closing element which can be moved along the joining axis and which is driven by a closing drive, and which cooperates with a lower face of the filled capsule lower part, and a counter holder which cooperates with an upper face of the capsule upper part. The counter holder can be arranged in a stop region which is spaced apart from a conveying region by the interposition of a transport region. A transport sleeve which fixes and transports the filled and fully joined capsule outside the conveying region is arranged in the transport region.