A closed-system grinding syringe (10, 110) is provided for liquefying and delivering a solid dosage form (20), including a barrel (22), a fluid port (30) disposed on a bottom wall (28) of the barrel (22), and a plunger (32). A head (36) of the plunger (32) is insertable into and moveable within the barrel (22) such that (a) a portion of the barrel (22) defines a closed-system syringe chamber (46) between the bottom barrel wall (28) and a lower surface (64) of the plunger head (36), and (b) a plunger-head annular seal (42) forms a fluid-tight seal between an outer surface (44) of the plunger head (36) and a cylindrical inner surface (26) of the barrel (22). A solid-dosage-form support disc (60, 360) is disposed below a bottom plunger wall (38) so as to define a grinding compartment (62) between the lower surface (64) of the bottom plunger wall (38) and an upper surface (66) of the solid-dosage-form support disc (60, 360), and is shaped so as to define a plurality of holes (68, 368) through the solid-dosage-form support disc (60, 360).

A chew toy is provided for dispensing medication to a user, comprising: a) an outer shell comprising an opening; and b) an inner compartment comprising a channel connecting the inner compartment to the opening; wherein the inner compartment comprises means for storing the medication and dispensing the medication through the channel and out of the opening when the user chews the chew toy. In some embodiments, the inner compartment comprises a syringe or a sac. In another embodiment, the inner compartment of the chew toy may comprise a channel that connects a first opening in the chew toy to a second opening connected to an external compartment comprising an external syringe, sac, or any other means for storing and dispensing the medication. Methods of using the chew toys to dispense medication to a user are also provided.

A system for intraoral fluid delivery comprises a rate-controlled and/or volume-controlled fluid supply device, a reservoir for holding one or more fluids to be delivered to a patient's oral cavity, a mouthpiece to be worn by a patient at least partially within the patient's oral cavity, and tubing to carry the one or more fluids from the fluid supply device to the mouthpiece. The mouthpiece comprises a fluid inlet adjacent and/or exterior to the patient's oral cavity when the mouthpiece is worn by the patient, a fluid outlet posterior to the fluid inlet, and a fluid channel therebetween.

A stable-foam inhalation-device cartridge for a stable-foam inhalation device which dispenses a stable foam to be consumed by a user. The cartridge is devoid of an electrical energisation component. The cartridge includes a flexible mixing chamber, first and second foam-generation elements, an expansion chamber, a partitioning element having one or more mixing members for agitating a consumable foam and a discharge element. The discharge element has an outlet opening an inlet opening and a discharge conduit which interconnects the inlet opening with the outlet opening. The discharge conduit has a longitudinal extent which locates the inlet opening at a position closer to the partitioning element than to the outlet opening.

Provided herein are devices, systems, kits and methods for treating skin conditions, ailments or diseases, such as skin warts. In some examples, a device for treating warts comprises a reservoir that includes a cantharidin formulation, and an applicator device in fluid communication with the reservoir that delivers the cantharidin formulation to a subject.

Methods for treating developmental or chronic cerebral nervous system disorders using 5-formyl-(6S)-tetrahydrofolate and pharmaceutically acceptable dosage forms therefor are provided.

A syringe includes a barrel, a plunger, and a sealing member creating a seal between the plunger and the barrel. The barrel includes a first portion with a first inner diameter and a second portion with a second inner diameter that is larger than the first inner diameter. The sealing member engages the first portion of the barrel to give rise to a first contact pressure when the barrel is filled with product. The first contact pressure is sufficient to maintain a gas-tight seal over the expected temperature ranges −25° C. to 40° C. A first force is applied to the plunger to overcome the first contact pressure and move the plunger out of the first portion and into the second portion to dispense product. The sealing member engages the second portion of the barrel to give rise to a second contact pressure that is lower than the first contact pressure. A second force lower than the first force is sufficient to overcome the second contact pressure and move the plunger in the second portion to continue dispensing product. The syringe may include a restraining element for accommodating expansion of the product during freezing.

A dispensing system including a handheld dispenser and a dispenser controller. The handheld dispenser may have a housing, a cartridge removably disposed within the housing and containing a dose form to be dispensed, the dose form with an active pharmaceutical ingredient (API), the cartridge having an internal piston movable within a reservoir containing the dose form and a port through a distal tip in communication with the reservoir, the distal tip being sized and configured to be inserted into the user's mouth. A motor disposed in the housing moves the piston to dispense a volume of the dose form from the cartridge through the port. The dispenser controller adjusts the volume of the dose form dispensed by the dispenser based on information about effectiveness of the API in treating a condition of the user.

System comprising a pre-fillable syringe with a syringe barrel and a syringe tip and a package suitable and intended for receiving the pre-fillable syringe, wherein the syringe tip is provided with a tip cap, wherein the system comprises a replacement cap for the pre-fillable syringe, wherein the package is suitable and intended for receiving the replacement cap.

A discharger for discharging a predetermined amount of fluid from a separate container including a discharge section defining a longitudinal axis and having a proximal end and a distal end and having a discharge passage for the fluid extending between an inlet opening and an outlet opening of the discharge section. The discharger further includes an intermediate section including a distal portion cooperating with the proximal end of the discharge section and a proximal portion defining a receiving space which is adapted to be loaded with the separate container holding an amount of fluid to be discharged by the discharger. The distal portion and the proximal portion are formed in one piece and are interconnected by a breakable section.