A device for regenerating musculoskeletal tissue having a scaffold comprised of fiber layers adapted to provide mechanical integrity to the scaffold in the form of increased tensile and compressive resistance and one or more other layers adapted to provide mechanical integrity and to provide a suitable biochemical environment.

Methods, systems, and devices are provided herein for preparing fiber matrices with differing degrees of anisotropy within a single matrix and controllable physical parameters, such as porosity.

An apparatus for accumulating cross-aligned fiber in an electrospinning device, comprising a multiple segment collector including at least a first segment, a second segment, and an intermediate segment, the intermediate segment positioned between the first and second segment to collectively present an elongated cylindrical structure; at least one electrically chargeable edge conductor circumferentially resident on the first segment and circumferentially resident on the second segment; a connection point on the first segment and on the second segment, the connection points usable for mounting the elongated cylindrical structure on a drive unit to rotate around a longitudinal axis; the elongated cylindrical structure holding electrospun fiber substantially aligned with the longitudinal axis when the edge conductors are excited with a charge of opposite polarity relative to charged fiber, and attracting electrospun fiber on to its surface around the longitudinal axis at least when the edge conductors are absent a charge or grounded.

An apparatus for collecting cross-aligned fiber threads, comprising an elongated assembly having a plurality of segments including at least a first segment, a second segment, and an intermediate segment, the first segment positioned at one end of the intermediate segment and the second segment positioned at an opposite end of the intermediate segment, each segment being electrically chargeable; an electrically chargeable emitter for electrospinning nanoscale fiber streams comprising charged fiber branches, the emitter having a tip positioned offset and between an edge of the first segment and an edge of the second segment; a support structure for rotating the elongated assembly about a longitudinal axis and applying an electrical charge to at least the edges of the first and second segment; at least one electrically chargeable steering electrode for attracting fiber streams, the at least one steering electrode chargeable with an electrical polarity opposing a charge applied to the emitter.

Described herein are nanofibers including an outer membrane and a core, wherein the outer membrane is made of fibroin and the core is a biocompatible and biodegradable polymer. Also described herein are a method for obtaining the nanofibers and the use thereof to convey bioactive molecules and/or particles and/or cells and/or in the treatment of diseases. Also described herein are powdered nanofibers, optionally suspended in an aqueous solution, a hydrogel system including the powdered nanofibers, and the use of the powdered nanofibers and of the hydrogel system to convey bioactive molecules and/or particles and/or cells and/or in the treatment of diseases.

A nanofiber producing apparatus 10 includes a spinning solution jetting means 11 having a conductive nozzle 13 for jetting a stock spinning solution for nanofiber production, an electrode 14 located away from the nozzle 13, a voltage generating means 101 generating a voltage between the nozzle 13 and the electrode 14, an air jetting means 15 located at such a position as to direct an air jet between the nozzle 13 and the electrode 14, and a nanofiber collecting means. The voltage generating means 101 generates a voltage so that the nozzle 13 serves as a positive pole and the electrode 14 as a negative pole. The electrode 14 is covered, on almost the entire area of its side facing the nozzle 13, with a covering 17 having a dielectric exposed on the surface thereof. The dielectric exposed on the surface of the covering has a thickness of 0.8 mm or greater.

A vascular graft that includes a biodegradable polyester electrospun tubular core; a biodegradable polyester outer sheath surrounding the biodegradable polyester tubular core; and a biodegradable poly(lactide) copolymer adhesive composition (i) disposed between the polyester electrospun tubular core and the polyester outer sheath, (ii) disposed between the polyester electrospun tubular core and the polyester outer sheath and on an outer surface of the of the polyester outer sheath, (iii) or disposed on an outer surface of the polyester outer sheath.

Apparatus for producing a three dimensional nanofiber structure includes (1) at least two spaced electrodes; (2) a spinner adapted to rotate the at least two spaced electrodes; (3) a syringe assembly adapted to eject a polymer solution from a syringe of the syringe assembly towards the at least two spaced electrodes while the at least two spaced electrodes are rotated by the spinner; and (4) a power supply assembly for providing the two spaced electrodes at a first electric potential, and for providing the syringe at a second electric potential which is different from the first electric potential. A composition of matter may include (1) a least one layer of nanofibers in which a distribution of angles of fibers is aligned; and (2) at least one gel layer, wherein the at least one layer of microfibers and the at least one gel layer alternate to form a laminate.

The present disclosure relates to a method for making a ceramic mini-tube configured for use in a fluid modification system. The method involves using an electrospinning system to receive a quantity of precursor solution. The electrospinning system creates an electric field which causes the precursor solution, when emitted, to be stretched into a fiber jet. The fiber jet is deposited on a collector resulting in a fiber mat. The fiber mat is removed from the collector, wherein the fiber mat is formed into a shape. The fiber mat is further processed so that the fiber mat retains a desired shape. A heat treatment operation is then performed to convert the fiber mat into a ceramic structure having the desired shape.

Provided in certain embodiments are high performance graphene fibers and yarns, including components and precursors thereof, and composites comprising the same. Also provided herein are methods of manufacturing such fibers, yarns, composites, and components/precursors thereof.