A production line is, suitable for the production of medicinal products that include at least one active ingredient. The production line includes an extruder for producing an extrudate from the active ingredient and at least one excipient intended to form an encapsulating matrix of the active ingredient, and a cooling member for cooling the extrudate at the outlet of the extruder. The extruder includes a barrel and at least two parallel screws housed in the barrel and interpenetrating with one another to mix the or each active ingredient with the or each excipient. The barrel is oriented vertically and the footprint occupied by the production line is less than 0.5 m.sup.2.

A breast milk collection and storage system and methods of use is described. The breast milk collection and storage system may include a milk container operable to hold and store breast milk for an extended period of time. The milk container may include a container wall with an oxygen blocking layer, a light blocking layer, and an inner surface that is non-adherent for lipids and proteins, a container opening surrounded by the container wall, and a foil seal operable to seal the container opening. The milk container may have low oxygen head space and a storage system to enable the rapid cooling of the breast milk.

A technique for tracking, for example, the temperature of one or more sample vials containing biological material stored in a low-temperature shipping vessel. Each sample vial has vial electronics that senses temperature and transmits temperature data to the reader head of a reader device, which has a controller that is not at the low temperature. In some implementations, the shipping vessel has a cap with a recess that houses the controller and a hollow plug that houses a cable that connects the controller to the reader head that is located in the vessel's cold interior sufficiently close to the sample vial to enable interaction with the vial electronics. In some implementations, the reader head transmits electrical power to the vial electronics. By tracking the temperature of individual sample vials rather than the temperature of the vessel interior, more-relevant temperature data is available.

A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (T.sub.g) that is greater than or equal to 70 C. and less than or equal to 45 C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.410.sup.6 cm.sup.3/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to 45 C.

A portable insulated medicament container is provided herein. The container comprising a housing defining a cavity for receiving medicament for maintaining temperature control of the medicament, the housing comprising an opening for accessing the cavity, and the housing further comprising one or more cooling elements disposed therein. A method for using a portable insulated medicament container is also provided herein. The method includes placing the medicament into the container without the need for a container warming period.

The present invention provides a transport container comprising; a first container having a first inner wall with a storage space for storing a transported object and a first outer wall provided on the outside of the first inner wall so as to form, with the first inner wall, a vacuum space therebetween; a first lid that is heat-insulating and is for removably sealing a first opening of the first container; a second container having a second inner wall with a space for storing the first container and the first lid and a second outer wall provided on the outside of the second inner wall so as to form, with the second inner wall, a vacuum space therebetween; a second lid that is heat-insulating and is for removably sealing a second opening of the second container; and a heat storage material for surrounding the transported object inside the storage space.

Disclosed are systems and methods for aseptically filling pharmaceutical containers with a pharmaceutical substance and then lyophilizing it. In one general aspect, the system and method can employ a lyophilizer loader subsystem having an interior chamber in communication with an interior chamber of a lyophilizer subsystem via a portal with a sealable door, with the collective interior being aseptically sealable. An articulated robotic arm can be employed to batch transfer to the lyophilizer subsystem container nests bearing the pharmaceutical containers. In one embodiment, the nests may be transferred serially to the loader subsystem, with the articulated robotic arm being configured to transfer the nests of containers in batches to the lyophilizer subsystem. The articulated robotic arm can also be configured to be used to move batches of nests within the lyophilizer subsystem. One implementation includes two articulated arms and a joint rotary wrist driven by two rotary shoulders.

A drug delivery system includes a storage container defining one or more storage compartments and having at least one container sensor coupled thereto, a container condition change mechanism coupled to the storage container for imparting a change on one or more conditions of the one or more storage compartments, at least one drug delivery device adapted to deliver a drug to a user and adapted to be at least partially disposed within one or more of the one or more storage compartments, at least one delivery device sensor, a delivery device condition change mechanism coupled to the drug delivery device, and a controller coupled to the storage container. The storage container may be adapted to hold a number of drug delivery devices within a number of sealable storage compartments. The container sensor is adapted to sense a condition of the storage container, and the delivery device sensor is adapted to sense a condition of the at least one drug delivery device. The controller is adapted to instruct the container condition change mechanism and/or the delivery device change mechanism to impart a change on at least one condition of the storage container and/or the drug delivery device.

A case includes a pocket for hermitically storing medical device(s) and medicine. The case may include a manual or motorized pump that can generate vacuum pressure within the pocket to thermally insulate the pocket from the atmosphere to minimize temperature fluctuations within the pocket. The case may also include a cooling and/or heating system to control the temperature within the pocket within a desired range to prolonging the potency and the life expectancy of the drug, such as epinephrine, stored within the pocket. The case may also be equip with a communication device that can link with user's mobile device so that in case of an emergency, the communication device can alert the mobile device, which can then notify emergency personal for assistance.

A portable cooler container with active temperature control system is provided. The active temperature control system is operated to heat or cool a chamber of a vessel to approach a temperature set point suitable for a medication stored in the cooler container.