Endodontic formulations and methods of use are provided. The formulations can be irrigant formulations for irrigating a root canal using an effective amount of Cysteamine or a Cysteamine derivative. The effective amount can be effective to inhibit the proliferation of at least one bacterial infection in the root canal patient. The effective amount can be effective to produce a percent reduction in Enterococcus faecalis in the canal wall of the patient of about 60% or more when administered to the patient. The effective amount can be effective to produce a percent reduction in Fusobacterium nucleatum in the canal wall of the patient of about 65% or more when administered to the patient. The formulations can be decalcifying formulations for reducing a calcification of a tissue in a root canal of a patient in need thereof. The decalcifying ability can be greater than a corresponding formulation such as EDTA and/or NaOCl.

Endodontic formulations and methods of use are provided. The formulations can be irrigant formulations for irrigating a root canal using an effective amount of Cysteamine or a Cysteamine derivative. The effective amount can be effective to inhibit the proliferation of at least one bacterial infection in the root canal patient. The effective amount can be effective to produce a percent reduction in Enterococcus faecalis in the canal wall of the patient of about 60% or more when administered to the patient. The effective amount can be effective to produce a percent reduction in Fusobacterium nucleatum in the canal wall of the patient of about 65% or more when administered to the patient. The formulations can be decalcifying formulations for reducing a calcification of a tissue in a root canal of a patient in need thereof. The decalcifying ability can be greater than a corresponding formulation such as EDTA and/or NaOCl.

Provided is a dental pretreatment material for dental tissue regeneration by use of dental pulp stem cells, particularly a dental pretreatment material effectively enabling dental tissue regeneration even by use of dental pulp stem cells of middle-aged or older individuals. The dental pretreatment material is characterized by comprising a serine protease, specifically trypsin. The dental pretreatment material comprising trypsin is used as an injection into a root canal before a root canal filling material comprising dental pulp stem cells and an extracellular matrix is inserted into the root canal as an attempt to regenerate a dental pulp and a dentin. The root canal filling material includes an ALK5 inhibitor, a CCR3 antagonist, or a CCL11 neutralizing antibody.

Provided are an application of a citrate metal salt in endodontic treatment, and a formulation obtained by preparation; said citrate metal salt is used for removing a tarnished layer, and the citrate metal salt is lithium citrate, sodium citrate, potassium citrate, or magnesium citrate. The citrate metal salt is co-formulated with a citrate metal salt-compatible single-chain cationic antimicrobial agent, achieving results that are currently achieved only by alternating rinsing with EDTA-containing and sodium hypochlorite preparations in endodontic treatment.

Provided are an application of a citrate metal salt in endodontic treatment, and a formulation obtained by preparation; said citrate metal salt is used for removing a tarnished layer, and the citrate metal salt is lithium citrate, sodium citrate, potassium citrate, or magnesium citrate. The citrate metal salt is co-formulated with a citrate metal salt-compatible single-chain cationic antimicrobial agent, achieving results that are currently achieved only by alternating rinsing with EDTA-containing and sodium hypochlorite preparations in endodontic treatment.

The invention relates to the application of photon energy to energize dental materials to enhance their physical handling characteristics, efficacy, ability to be delivered, reactivity, polymerization, and/or post-cure mechanical properties, among other attributes.

The invention relates to the field of microflora destruction technologies (bacteria, protozoan fungi, etc.), namely microorganisms in sessile state (hereinafterbiofilm), and can be used in medicine, industry, agriculture and various fields of technology for the destruction of biological films which are highly organized communities of bacteria in the extracellular polymeric substance (hereinafter referred to as the exopolymer matrix) formed on surfaces of different origin (biological, industrial, etc.). Pre-prepare the composition for the destruction of microorganisms in sessile state, for which dissolve the oxidizing agent and the substance that blocks the OH-group, in a solvent. An aqueous solution of sodium peroxodisulfate at a concentration of 10.00 wt. % And sodium hydroxide at a concentration of 15.00 wt. % Is used as components from which the composition is prepared for the destruction of microorganisms in the sessile state. Since the pH of the composition is greater than 10.50, no protective reagent is added. After preparation of the composition for the destruction of microorganisms in sessile state, it is introduced into the object, the surface of which contains a biofilm. As a result of the introduction of the claimed composition for the destruction of microorganisms in the sessile state and its exposure for 10 minutes, the quantitative indicator of the enzyme urease of the material from the root canal was 0.00 kat/l, which indicates that a complete destruction (dissolution) of the exopolymeric biofilm matrix occurred and bacteria that have passed into the plankton form are completely destroyed by the bactericidal action of the claimed composition.

The present invention provides a photosensitising composition comprising a mixture of at least one oxygen carrier, at least one oxidising agent and at least one surfactant, and its uses. The ratio of the at least one oxygen carrier to the at least one oxidising agent to the at least one surfactant may be in the range of 50:40:10 to 80:19.8:0.2. The photosensitising composition may be used for treating and/or preventing conditions caused by microorganisms.

The endodontic point containing ultrasonic deformable material is a filler for root canal therapy that decreases in viscosity when subjected to ultrasonic waves. Once the point is inserted into a prepared tooth space, such as a prepared and cleaned root canal, the point is subjected to ultrasonic waves. The ultrasonic waves cause the viscosity of the point to lower, thus allowing the point to flow into voids in the tooth space and allow air to escape from the voids. The point then hardens and remains in the shape acquired when at low viscosity once application of the ultrasonic waves is stopped.

Provided herein are compositions and kits including trichloroacetic acid, and methods of using the same for debridement during endodontic treatment.