Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

The present application provides compositions configured to be provided in a flowable, liquid form but that are configured to transition to a solid or semi-solid gel based upon a change in pH. The change in pH can arise from one or more materials utilized in the composition itself or based upon encountering an environment with a significantly different pH. The compositions are particularly suited for use as a teat sealant in non-human mammals, particularly cattle.

The present disclosure provides compositions and methods for modulating various mammary' disorders and conditions. The disclosure further provides a therapeutic combination of a composition of at least one casein protein or casein-derived peptide; and a teat seal composition.

A safety valve arrangement and method, having an upstream block valve, a downstream block valve, and a pressure monitored galley between the upstream valve and the downstream valve.

A teat dip fluid manifold and methods for distributing teat dip fluids, and including redundant valve sets and pressure monitoring between valve pairs to determine valve condition.

The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising: a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic-pH sensitive polymer is larger than 1.

A method of preventing intramammary infection and accelerating involution by administration of a biological response modifier, specifically a chitosan solution, to the teat of a lactating mammal at drying-off A chitosan solution neutralized with a weak base such as -glycerophosphate can remain liquid at room temperature for injection into a teat, but can form a hydrogel at body temperature inside the teat. The neutralized chitosan solution can also be optionally co-administered with a teat sealant.

The present invention relates to a topical composition which is mixture of natural ingredients of plant and animal origin, to the process of its preparation, to its use for treatment and/or prophylaxis of mastitis and/or edema in female mammals, more particularly to its use for treatment and/or prophylaxis of mastitis and/or udder edema in dairy animals. The topical composition according to the invention is mixture of natural ingredients of plant and animal origin, wherein the topical composition comprises: sugar, carboxylic acid solution, egg white and vehicle.

The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a gelation agent, and optional additional ingredients in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.

Compositions and formulations comprising a non-neutralized tocol phosphate and a vitamin A compound, which are suitable for the treatment of inflammation and/or infection in breast or udder tissue, more particularly in a mammary gland, reducing the somatic cell count in a lactating subject and supplementing vitamin E levels in a subject.