A method for producing molecular assemblies of an amphiphilic block polymer includes applying a polymer solution in a layered shape on a planar base member, the polymer solution including an amphiphilic block polymer and a solvent, the amphiphilic block polymer having a hydrophilic block chain including 20 or more sarcosine units and a hydrophobic block chain including 10 or more lactic acid units, forming a polymer film on the planar base member by removing the solvent from a coated layer of the polymer solution, and obtaining molecular assemblies by bringing the polymer film into contact with a water-based liquid. The planar base member is a flexible long film.

Compositions and methods of treatment involving transpore delivery of an active ingredient are provided.

The present invention is directed to methods for improving the therapeutic outcome of treatment with roflumilast. The therapeutic outcome is improved by consistent delivery and/or a longer plasma half-life of a topically administered roflumilast composition. The roflumilast composition preferably includes dicetyl phosphate, ceteth-10 phosphate, diethylene glycol monoethyl ether, and/or hexylene glycol.

The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film. The invention further relates to edible multi-layer films that dissolve in water. In particular, the edible multi-layer films have a first water-soluble film layer and one or more additional water-soluble film layers in at least partial face-to-face engagement with the first film layer.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural and artificial surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.

The present invention relates to methods of treating female reproductive tract irritation (such as pain and pruritus) or/and inflammation.

Valproate is useful as an antifungal agent. The valproate compositions can be used to treat fungal infections. The valproate compositions can be formulated as topical antifungals.

A microcapsule for a topical treatment for improving skin and mucus membranes condition includes a matrix material in a solid state, in which a live probiotic microorganism is encapsulated, wherein the live microorganism is released from the matrix upon contact with a skin surface and/or mucous membranes of the human or warm-blooded animal body, wherein the matrix material has a melting or softening temperature selected from the range of 20-43 C., and wherein the live probiotic microorganism is present in the range of 0.001 to 80 wt. % from the weight of the matrix material.

This invention is related to novel topical compositions and methods thereof for delivery of drugs to a subject, more specifically to deliver sex hormones, opioids, antidiabetics, smoking cessation agents, and psychoactive drugs to a patient via skin pores.

A wound healing composition and method for treating acute and chronic wounds and skin conditions includes a wound healing composition or formulation including a mixture of buckwheat honey, methylglyoxal and povidone-iodine.