The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.

Disclosed herein are nanoemulsions, the nanoemulsions comprising biologically active ingredients. Further disclosed are processes for preparing the nanoemulsions and methods of their use.

The present invention relates to compounds of Formula (I) and compositions containing one or more compounds of Formula (I). The compounds and compositions are useful as anti-viral agents and may be used in the treatment or prevention of diseases caused by ribonucleic acid (RNA) viruses.

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The present invention relates to compounds of Formula (I) and compositions containing one or more compounds of Formula (I). The compounds and compositions are useful as anti-viral agents and may be used in the treatment or prevention of diseases caused by ribonucleic acid (RNA) viruses.

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A composition comprising a cannabidiol at least one compound selected from the group consisting of cannabichromenes, cannabicyclols, cannabidiols, cannabielsoins, cannabigerols, cannabinols, cannabinodiols, cannabitriols, delta-8-tetrahydrocannabinols, delta-9-tetrahydrocannabinols, or any combination thereof; and a terpene. A nanoemulsion comprising a cannabidiol; a terpene; and an aqueous fluid, wherein the cannabidiol and terpene are in an emulsion in the aqueous fluid. A full spectrum hemp oil composition comprising at least one stereoisomer of tetrahydrocannabinol; cannabinodiol; and at least one cannabinoid selected from the group consisting of cannabichromenes, cannabicyclols, cannabidiols, cannabielsoins, cannabigerols, cannabinols, cannabinodiols, cannabitriols, and a combination thereof.

A composition comprising a cannabidiol at least one compound selected from the group consisting of cannabichromenes, cannabicyclols, cannabidiols, cannabielsoins, cannabigerols, cannabinols, cannabinodiols, cannabitriols, delta-8-tetrahydrocannabinols, delta-9-tetrahydrocannabinols, or any combination thereof; and a terpene. A nanoemulsion comprising a cannabidiol; a terpene; and an aqueous fluid, wherein the cannabidiol and terpene are in an emulsion in the aqueous fluid. A full spectrum hemp oil composition comprising at least one stereoisomer of tetrahydrocannabinol; cannabinodiol; and at least one cannabinoid selected from the group consisting of cannabichromenes, cannabicyclols, cannabidiols, cannabielsoins, cannabigerols, cannabinols, cannabinodiols, cannabitriols, and a combination thereof.

The present formulation in one embodiment is a cream that utilizes cannabinoids and terpenes (essential oils) which have powerful antibacterial activity, proven through multiple rounds of in vitro testing, to kill the most prevalent indigenous skin bacteria, including Streptococcus, Staphylococcus, and P. acnes within 30 seconds of contact. There is some independent antimicrobial activity of the cream base as well. The cream is more suitable to use on human skin because it is an emollient, is soothing, smells and feels good, and it penetrates below the dermis (lower skin level) to enter the sebaceous glands where P. acnes bacteria resides.

The present formulation in one embodiment is a cream that utilizes cannabinoids and terpenes (essential oils) which have powerful antibacterial activity, proven through multiple rounds of in vitro testing, to kill the most prevalent indigenous skin bacteria, including Streptococcus, Staphylococcus, and P. acnes within 30 seconds of contact. There is some independent antimicrobial activity of the cream base as well. The cream is more suitable to use on human skin because it is an emollient, is soothing, smells and feels good, and it penetrates below the dermis (lower skin level) to enter the sebaceous glands where P. acnes bacteria resides.

The present formulation in one embodiment is a cream that utilizes cannabinoids and terpenes (essential oils) which have powerful antibacterial activity, proven through multiple rounds of in vitro testing, to kill the most prevalent indigenous skin bacteria, including Streptococcus, Staphylococcus, and P. acnes within 30 seconds of contact. There is some independent antimicrobial activity of the cream base as well. The cream is more suitable to use on human skin because it is an emollient, is soothing, smells and feels good, and it penetrates below the dermis (lower skin level) to enter the sebaceous glands where P. acnes bacteria resides.

A nutritional supplement composition that extends the utility of the prior art methods to include enhanced utility for bone health via modulation of the RANK, RANKL, NFKB signaling system and incorporates unrelated, unforeseen benefits on brain health based on the beneficial impact of the same signaling system on brain health thus preventing loss of neurological function and/or normalizing impaired or deteriorating neurological function in humans based on: (1) mitigation of the adverse impact of dysregulated acid-base balance, (2) dysregulation of prostaglandin physiology, (3) abnormalities in RANK, RANKL, NFKB physiology. reversing elevated NFKB, RANK, RANKL signaling. The nutrients that are ideal for the desired result are Honokiol, Magnolol, Beta-caryophyllene, Palmitoylethanolamide, Hesperidin, Schisandrin, Ferulic Acid, Beta-carotene, Lutein, Lycopene, Sulforaphane, and Ellagic Acid.