A61K31/285

Method for treating a glycoprotein-related disease
10258597 · 2019-04-16 ·

A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective amount of an organic arsenic compound to a subject in need thereof.

Method for treating a glycoprotein-related disease
10258597 · 2019-04-16 ·

A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective amount of an organic arsenic compound to a subject in need thereof.

Salts and prodrugs of 1-methyl-D-tryptophan

Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.

Salts and prodrugs of 1-methyl-D-tryptophan

Presently provided are indoximod prodrug and salt compounds and pharmaceutical compositions comprising salts and prodrugs of indoximod, that produce enhanced plasma concentration and exposure to indoximod compared to direct administration of indoximod, in patients in need of treatment of immunosuppression mediated by the indoleamine-2,3-dioxygenase pathway, such as patients with cancer or chronic infectious diseases.

USE OF ADENOSINE RECEPTOR SIGNALING TO REGULATE P-GP FUNCTION
20190038630 · 2019-02-07 ·

The present invention relates to a method of inhibiting p-glycoprotein (P-gp) expression in a cell. The method involves contacting a cell expressing P-gp with a composition comprising an effective amount of an A2A adenosine receptor (A2A AR) agonist to inhibit P-gp expression in the cell. Methods of enhancing the bioavailability of a chemotherapeutic in a subject having multi-drug resistant (MDR) cancer and methods of increasing P-gp-mediated efflux in a cell are also disclosed.

APPLICATIONS OF P14K INHIBITOR IN INTRACELLULAR PROTEIN MISFOLDING-RELATED DISEASES AND LYSOSOMAL STORAGE DISEASES

Provided are uses of a PI4KIII? specific inhibitor in preventing or treating intracellular protein misfolding-related diseases, also provided are uses of the PI4KIII? specific inhibitor in preventing or treating lysosomal storage diseases.

APPLICATIONS OF P14K INHIBITOR IN INTRACELLULAR PROTEIN MISFOLDING-RELATED DISEASES AND LYSOSOMAL STORAGE DISEASES

Provided are uses of a PI4KIII? specific inhibitor in preventing or treating intracellular protein misfolding-related diseases, also provided are uses of the PI4KIII? specific inhibitor in preventing or treating lysosomal storage diseases.

APPLICATIONS OF P14K INHIBITOR IN INTRACELLULAR PROTEIN MISFOLDING-RELATED DISEASES AND LYSOSOMAL STORAGE DISEASES

Provided are uses of a PI4KIII? specific inhibitor in preventing or treating intracellular protein misfolding-related diseases, also provided are uses of the PI4KIII? specific inhibitor in preventing or treating lysosomal storage diseases.

Method for treating a glycoprotein-related disease
10154985 · 2018-12-18 ·

A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective amount of an organic arsenic compound to a subject in need thereof.

Method for treating a glycoprotein-related disease
10154985 · 2018-12-18 ·

A method for treating a glycoprotein-related disease is disclosed, which comprises: administering a first effective amount of phenol red and a second effective amount of an organic arsenic compound to a subject in need thereof.