An implantable delivery device for dispensing a medicament that includes a first microporous material that is bonded to a second microporous material. The first microporous material has a first microporous layer including a plurality of pores sized to permit tissue ingrowth and a second microporous layer including a plurality of pores sized to permit tissue ingrowth. The second microporous material has a third microporous layer including a plurality of pores sized to resist tissue ingrowth and a fourth microporous layer including a plurality of pores sized to permit tissue ingrowth. The second microporous layer is bonded to the third microporous layer to thereby form a reservoir for receiving the medicament. The first and second microporous materials are configured to meter a rate at which the medicament is dispensed from the reservoir when the delivery device is implanted.

The present invention relates to methods of preparing ophthalmological compositions comprising latanoprost along with or replaced by other prostaglandin analogs (e.g., latanoprost derivatives or analogs), a stabilizing amount of a suitable and stabilizing polyoxyl castor oil (e.g., a hydrogenated polyoxyl castor oil), and one or more pharmaceutically acceptable excipients, wherein the composition remains stable when stored at room temperature conditions and/or accelerated conditions. Further, the invention also provides methods of use of the ophthalmological compositions for conditions including lowering intra-ocular pressure and treatment of glaucoma.

The subject invention pertains to methods and compositions for the treatment of erectile dysfunction (ED) (e.g., impotence) in a subject in need thereof utilizing one or more cannabinoid and one or more anti-ED drug.

The subject invention pertains to methods and compositions for the treatment of erectile dysfunction (ED) (e.g., impotence) in a subject in need thereof utilizing one or more cannabinoid and one or more anti-ED drug.

The subject invention pertains to methods and compositions for the treatment of erectile dysfunction (ED) (e.g., impotence) in a subject in need thereof utilizing one or more cannabinoid and one or more anti-ED drug.

A mucoadhesive solid or semisolid ocular delivery systems that includes a matrix of preactivated thiomers, preferably under the form of ocular inserts or ocular films. The ocular delivery systems are useful for ocular drug delivery for the treatment of ocular diseases. The delivery systems of the invention can also be used for alleviating ocular conditions such as dry eye syndrome.

A mucoadhesive solid or semisolid ocular delivery systems that includes a matrix of preactivated thiomers, preferably under the form of ocular inserts or ocular films. The ocular delivery systems are useful for ocular drug delivery for the treatment of ocular diseases. The delivery systems of the invention can also be used for alleviating ocular conditions such as dry eye syndrome.

The present invention relates to a topical composition useful for the treatment of hair disorders such as androgenetic alopecia, hirsutism, alopecia of the eyebrows and eyelashes, and hypotrichosis.

The present invention relates to a topical composition useful for the treatment of hair disorders such as androgenetic alopecia, hirsutism, alopecia of the eyebrows and eyelashes, and hypotrichosis.

Provided are methods and compositions for promoting tissue (e.g., muscle) regeneration using one or more activators of fatty acid oxidation, such as one or more PPARγ activators. The methods and compositions described herein are also useful for promoting tissue growth, inducing proliferation of stem cells, inducing differentiation of tissuegenic cells (e.g., myogenic cells), and treating a disease or condition associated with a tissue (e.g., muscle), such as tissue injury, degeneration or aging, in an individual.