This application relates to a composition for preventing, treating, and improving skeletal muscle atrophy, the composition including an organoselenium compound. The composition recovered the thickness of muscle fiber reduced by dexamethasone treatment. In addition, the treatment of mice in a muscle loss model showed that the composition had an effect of reducing damaged muscle and of restoring muscle mass. Therefore, it is expected that the composition can be effectively used for the treatment, prevention, or improvement of muscle atrophy.

Compounds of the general formula

##STR00001##

are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also described.

Compounds of the general formula

##STR00001##

are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also described.

The present invention relates to compositions and methods for treatment of cholangiocarcinoma and in particular to combination therapies comprising panobinostat compositions in combination with other cytotoxic agents, e.g. agents that potentiate the effects of panobinostat, for use in the treatment of cholangiocarcinoma. Pharmaceutical compositions comprising panobinostat and other cytotoxic agents are also provided.

The present invention relates to compositions and methods for treatment of cholangiocarcinoma and in particular to combination therapies comprising panobinostat compositions in combination with other cytotoxic agents, e.g. agents that potentiate the effects of panobinostat, for use in the treatment of cholangiocarcinoma. Pharmaceutical compositions comprising panobinostat and other cytotoxic agents are also provided.

The present invention describes cannabinoid formulations that combine cannabinoids, such as CBD, with other active agents within the NAD+ precursor class of compounds which, in combination, provide synergistic anti-inflammatory effects. These preparations are capable of increasing anti-inflammatory effects when compared to each individual compound, and are further capable of delivery through a variety of administration routes.

The present invention describes cannabinoid formulations that combine cannabinoids, such as CBD, with other active agents within the NAD+ precursor class of compounds which, in combination, provide synergistic anti-inflammatory effects. These preparations are capable of increasing anti-inflammatory effects when compared to each individual compound, and are further capable of delivery through a variety of administration routes.

Disclosed herein are agents that enhance muscle stem cell engraftment, as well as methods and compositions using the same.

Disclosed herein are agents that enhance muscle stem cell engraftment, as well as methods and compositions using the same.

Provided is a method of treating or lessening the severity of pain in a subject, comprising administering to the subject a compound of formula (I), defined as described herein, or a pharmaceutically acceptable salt thereof.