Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

The present patent application relates to the use of an innovative amino acid derivative of glucosamine having the Formula 1 of the general structure which follows, or of a pharmaceutical composition which contains it as a single active ingredient or in association with one or more further active ingredients for the preparation of a medicament for the treatment or prophylaxis of diseases involved mainly with the regulation of the turnover of macromolecules that make up the ECM of connective tissue in general and more specifically of the cartilage. ##STR00001##

The present patent application relates to the use of an innovative amino acid derivative of glucosamine having the Formula 1 of the general structure which follows, or of a pharmaceutical composition which contains it as a single active ingredient or in association with one or more further active ingredients for the preparation of a medicament for the treatment or prophylaxis of diseases involved mainly with the regulation of the turnover of macromolecules that make up the ECM of connective tissue in general and more specifically of the cartilage. ##STR00001##

The present invention relates to a composition for preventing, improving or treating psoriasis containing an immunomodulator and glucosamine. Cyclosporine, an immunomodulator, is difficult to administer for a long time due to side effects thereof, and, when the administration of cyclosporine is discontinued, lesions tend to deteriorate to an original state thereof. However, according to the present invention, the co-administration of cyclosporine and glucosamine, even when the dose of cyclosporine is reduced, may exert a far superior effect on the treatment or improvement of psoriasis than the administration of cyclosporine and glucosamine alone.

The present invention relates to a composition for preventing, improving or treating psoriasis containing an immunomodulator and glucosamine. Cyclosporine, an immunomodulator, is difficult to administer for a long time due to side effects thereof, and, when the administration of cyclosporine is discontinued, lesions tend to deteriorate to an original state thereof. However, according to the present invention, the co-administration of cyclosporine and glucosamine, even when the dose of cyclosporine is reduced, may exert a far superior effect on the treatment or improvement of psoriasis than the administration of cyclosporine and glucosamine alone.

The present invention relates to a composition for preventing, improving or treating psoriasis containing an immunomodulator and glucosamine. Cyclosporine, an immunomodulator, is difficult to administer for a long time due to side effects thereof, and, when the administration of cyclosporine is discontinued, lesions tend to deteriorate to an original state thereof. However, according to the present invention, the co-administration of cyclosporine and glucosamine, even when the dose of cyclosporine is reduced, may exert a far superior effect on the treatment or improvement of psoriasis than the administration of cyclosporine and glucosamine alone.

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.

A composition for relieving pain, and methods of making and using the composition, whereby the composition comprises an amount of sugar or sugar alcohol; and an amount of vehicle; wherein the composition is formulated for transdermal administration; and wherein, upon transdermal administration, the composition is effective to relieve pain. As to particular embodiments, the composition further comprises an amount of alkalizing agent.