Methods and compositions for treating post-surgery laxity of tendons or tendon repair are provided that utilize 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo®. Also provided is a device to deliver 1,2,3,4,6-pentagalloyl glucose (PGG) or analogues or derivatives thereof or LeGoo® to the tissue to be treated.

Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described.

Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described.

Methods of treating HMGB1-mediated inflammation by administering a therapeutically effective amount of an MD2-antagonist to a subject in need thereof are described. The novel MD2 antagonist tetrapeptide P5779 is also described.

The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate or sucralfate and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.

The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate or sucralfate and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.

The present invention provides compositions comprising granulocyte-macrophage colony-stimulating factor (GM-CSF), sucrose octasulfate or sucralfate and hyaluronic acid for the treatment, pre-emptive treatment or prophylaxis of ulcers, wounds and other injuries to the skin or membranes of the body. Other aspects of the invention are methods of treatment or prevention using the compositions described, as well as an application device for use in the methods provided.

Encapsulation of MPLA in HPG-PLA nanoparticles having bioadhesive functional groups on the surface (“BNPs”) prolongs the local antitumor immune response in melanoma and boosts the adaptive immune response conferred by MPLA due to the polymer's bioadhesive properties. Delivery of MPLA in BNP prolongs the host's antitumor response with lower quantities of MPLA. Studies in mice showed that NPs delivered intratumorally have good lymphatic drainage and accumulate in lymph nodes, with prolonged dendritic cell maturation in vivo with intratumoral delivery of BNP-MPLA compared to free MPLA and NNP-MPLA.

Antiviral compounds, compositions and method are presented. The composition comprises helichrysetin, cinanserin, baicalin, fangchinoline, timosaponin B, cepharanthine, tetrandrine, bavachalcone B, rosmarinic acid, formononetin, baicalein, kazinol A, penta-O-beta-glucose hydrate, cinnamanilide, or an antiviral derivative, ester, salt, hydrate, anhydrate, polymorph, or tautomer of any of the foregoing and an excipient. The excipient may be pharmaceutically acceptable. The excipient may comprise at least one compound that does not occur naturally with helichrysetin, cinanserin, baicalin, fangchinoline, timosaponin B, cepharanthine, tetrandrine, bavachalcone B, rosmarinic acid, formononetin, baicalein, kazinol A, penta-O-beta-glucose hydrate, or cinnamanilide in nature. The method comprises administering a pharmaceutical composition comprising helichrysetin, cinanserin, baicalin, fangchinoline, timosaponin B, cepharanthine, tetrandrine, bavachalcone B, rosmarinic acid, formononetin, baicalein, kazinol A, penta-O-beta-glucose hydrate, cinnamanilide, or an antiviral derivative, ester, salt, hydrate, anhydrate, polymorph, or tautomer of any of the foregoing and a pharmaceutically acceptable excipient to a patient who has, is suspected of having, or is susceptible to a viral infection.

Antiviral compounds, compositions and method are presented. The composition comprises helichrysetin, cinanserin, baicalin, fangchinoline, timosaponin B, cepharanthine, tetrandrine, bavachalcone B, rosmarinic acid, formononetin, baicalein, kazinol A, penta-O-beta-glucose hydrate, cinnamanilide, or an antiviral derivative, ester, salt, hydrate, anhydrate, polymorph, or tautomer of any of the foregoing and an excipient. The excipient may be pharmaceutically acceptable. The excipient may comprise at least one compound that does not occur naturally with helichrysetin, cinanserin, baicalin, fangchinoline, timosaponin B, cepharanthine, tetrandrine, bavachalcone B, rosmarinic acid, formononetin, baicalein, kazinol A, penta-O-beta-glucose hydrate, or cinnamanilide in nature. The method comprises administering a pharmaceutical composition comprising helichrysetin, cinanserin, baicalin, fangchinoline, timosaponin B, cepharanthine, tetrandrine, bavachalcone B, rosmarinic acid, formononetin, baicalein, kazinol A, penta-O-beta-glucose hydrate, cinnamanilide, or an antiviral derivative, ester, salt, hydrate, anhydrate, polymorph, or tautomer of any of the foregoing and a pharmaceutically acceptable excipient to a patient who has, is suspected of having, or is susceptible to a viral infection.