The present disclosure relates to 2-alkynylmannose Derivative and Application Thereof. The mannose derivatives, and a pharmaceutically acceptable salt, an isotope, and an isomer thereof have a structure shown as formula I:

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and are used for treating or preventing bacterial infections. The present disclosure also provides pharmaceutically acceptable compositions comprising the above compounds and their use in the treatment or prevention of bacterial infections.

The present invention provides a novel glycerol glucoside-based compound having excellent ultraviolet light shielding performance and anti-inflammatory effect, and a composition including the compound for ultraviolet light shielding or anti-inflammation.

A method of extracting a Rhodiola plant comprising the steps of harvesting and drying the plant; extracting the alkaloids from the plant in a solvent; filtering the solvent-Rhodiola plant mixture to remove the solvent and extracted alkaloids from a spent plant matter; drying the spent plant matter; purifying and separating the extracted alkaloids from the solvent; and mixing the purified alkaloids back into the dried spent plant matter. Also, products of the method include vaporizing liquids, medicinal compositions, kief compositions, rolling papers, and filters for tobacco and vaporizing equipment comprising the mixture of the purified alkaloids and the dried spent plant matter produced according to the method. Further disclosed is a Rhodiola plant having approximately 1.3-8.57% total phenolic compounds containing 1-3.5% salidrosides and 0.03-3.6% Rosavins.

A method of extracting a Rhodiola plant comprising the steps of harvesting and drying the plant; extracting the alkaloids from the plant in a solvent; filtering the solvent-Rhodiola plant mixture to remove the solvent and extracted alkaloids from a spent plant matter; drying the spent plant matter; purifying and separating the extracted alkaloids from the solvent; and mixing the purified alkaloids back into the dried spent plant matter. Also, products of the method include vaporizing liquids, medicinal compositions, kief compositions, rolling papers, and filters for tobacco and vaporizing equipment comprising the mixture of the purified alkaloids and the dried spent plant matter produced according to the method. Further disclosed is a Rhodiola plant having approximately 1.3-8.57% total phenolic compounds containing 1-3.5% salidrosides and 0.03-3.6% Rosavins.

The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

A method of extracting a Rhodiola plant comprising the steps of harvesting and drying the plant; extracting the alkaloids from the plant in a solvent; filtering the solvent-Rhodiola plant mixture to remove the solvent and extracted alkaloids from a spent plant matter; drying the spent plant matter; purifying and separating the extracted alkaloids from the solvent; and mixing the purified alkaloids back into the dried spent plant matter. Also, products of the method include vaporizing liquids, medicinal compositions, kief compositions, rolling papers, and filters for tobacco and vaporizing equipment comprising the mixture of the purified alkaloids and the dried spent plant matter produced according to the method. Further disclosed is a Rhodiola plant having approximately 1.3-8.57% total phenolic compounds containing 1-3.5% salidrosides and 0.03 — 3.6% Rosavins

A method of extracting a Rhodiola plant comprising the steps of harvesting and drying the plant; extracting the alkaloids from the plant in a solvent; filtering the solvent-Rhodiola plant mixture to remove the solvent and extracted alkaloids from a spent plant matter; drying the spent plant matter; purifying and separating the extracted alkaloids from the solvent; and mixing the purified alkaloids back into the dried spent plant matter. Also, products of the method include vaporizing liquids, medicinal compositions, kief compositions, rolling papers, and filters for tobacco and vaporizing equipment comprising the mixture of the purified alkaloids and the dried spent plant matter produced according to the method. Further disclosed is a Rhodiola plant having approximately 1.3-8.57% total phenolic compounds containing 1-3.5% salidrosides and 0.03 — 3.6% Rosavins

Provided herein is a composition to reduce DNA and hepatic damage and to enhance repair thereof. More particularly the composition includes a combination of active ingredients which can be used in a beverage composition and also relates to a beverage composition including said synergistic composition of active ingredients, wherein each active ingredient in the combination composition and/or beverage composition in appropriate concentration synergistically reduces the DNA damage as well as hepatic damage due to alcohol consumption and/or due to other reasons. The composition also enhances repair of the DNA and hepatic which has already been damaged. The composition also synergistically reduces hangover, modulates and/or alleviates immunology parameters and CNS parameters due to alcohol consumption and due to other reasons. Further a beverage composition including above synergistic composition and method of preparation thereof is provided.

Provided herein is a composition to reduce DNA and hepatic damage and to enhance repair thereof. More particularly the composition includes a combination of active ingredients which can be used in a beverage composition and also relates to a beverage composition including said synergistic composition of active ingredients, wherein each active ingredient in the combination composition and/or beverage composition in appropriate concentration synergistically reduces the DNA damage as well as hepatic damage due to alcohol consumption and/or due to other reasons. The composition also enhances repair of the DNA and hepatic which has already been damaged. The composition also synergistically reduces hangover, modulates and/or alleviates immunology parameters and CNS parameters due to alcohol consumption and due to other reasons. Further a beverage composition including above synergistic composition and method of preparation thereof is provided.

The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.