Methods of treatment are provided herein, including administration of a population cells modified to enforce expression of an E-selectin and/or an L-selectin ligand, the modified cell population having a cell viability of at least 70% after a treatment to enforce such expression.

Methods of treatment are provided herein, including administration of a population cells modified to enforce expression of an E-selectin and/or an L-selectin ligand, the modified cell population having a cell viability of at least 70% after a treatment to enforce such expression.

Methods for treating radiation or chemical injury are described that comprise administering to a subject a therapeutically effective amount of adherent stromal cells. Methods of preparing adherent stromal cells and pharmaceutical compositions comprising the cells are also described.

A fat conditioning apparatus includes a conditioning vessel enclosing a conditioning chamber and a displacable plug. The conditioning chamber is bounded on one end by the displacable plug and has a variable volume that is a function of the position of the plug within the conditioning vessel. The apparatus has utility in a fat conditioning method, wherein the conditioning chamber contains a harvested fat emulsion. A washing liquid is injected into the conditioning chamber and mixes with the harvested fat emulsion, thereby displacing the plug in an outward expansion direction and expanding the variable volume of the conditioning chamber. The resulting mixture of harvested fat emulsion and washing liquid is stratified in the conditioning chamber into a contaminant-lean fat fraction and a contaminant-rich remainder fraction. The fat fraction, which is substantially free of the remainder fraction, is recovered from the conditioning chamber as a desired product of the method.

A fat conditioning apparatus includes a conditioning vessel enclosing a conditioning chamber and a displacable plug. The conditioning chamber is bounded on one end by the displacable plug and has a variable volume that is a function of the position of the plug within the conditioning vessel. The apparatus has utility in a fat conditioning method, wherein the conditioning chamber contains a harvested fat emulsion. A washing liquid is injected into the conditioning chamber and mixes with the harvested fat emulsion, thereby displacing the plug in an outward expansion direction and expanding the variable volume of the conditioning chamber. The resulting mixture of harvested fat emulsion and washing liquid is stratified in the conditioning chamber into a contaminant-lean fat fraction and a contaminant-rich remainder fraction. The fat fraction, which is substantially free of the remainder fraction, is recovered from the conditioning chamber as a desired product of the method.

The present disclosure provides a method for treating arthritis by using a stem cell preparation. The stem cell preparation of the present disclosure can effectively delay cartilage degeneration caused by arthritis, and it is confirmed by whole blood analysis and blood biochemical analysis that the stem cell preparation in the form of three-dimensional stem cell spheres provides a safe treatment for arthritis. The present disclosure also provides a method for preparing the stem cell preparation.

The present invention involves implants suitable for surgical implantation into subjects. In some embodiments the implants comprise a biocompatible scaffold material and blood vessels containing engineered endothelial cells—such as E4ORF1+ engineered endothelial cells or engineered endothelial cells that express certain marker molecules. The present invention provides implants, methods for preparing such implants, and methods of treatment utilizing such implants.

The present invention involves implants suitable for surgical implantation into subjects. In some embodiments the implants comprise a biocompatible scaffold material and blood vessels containing engineered endothelial cells—such as E4ORF1+ engineered endothelial cells or engineered endothelial cells that express certain marker molecules. The present invention provides implants, methods for preparing such implants, and methods of treatment utilizing such implants.

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine syndrome associated with a high risk for the development of insulin resistance, type 2 diabetes (T2D), obesity, dyslipidemia, and cardiovascular disease. There are no known therapies for the 9-18% of women afflicted with PCOS. Provided herein are methods for the treatment and/or prevention of at least one symptom of PCOS. Also provided herein are methods for the treatment and/or prevention of PCOS.

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine syndrome associated with a high risk for the development of insulin resistance, type 2 diabetes (T2D), obesity, dyslipidemia, and cardiovascular disease. There are no known therapies for the 9-18% of women afflicted with PCOS. Provided herein are methods for the treatment and/or prevention of at least one symptom of PCOS. Also provided herein are methods for the treatment and/or prevention of PCOS.