A method of treating cervical cancer in a patient in need is described that includes implanting a fast release implant containing an effective amount of Cis-Pt within a cervical cancer lesion. The implant includes a polymer and a therapeutic load homogenously distributed throughout the polymer. The implant assumes a solid phase at room temperature and assumes a liquid phase at a body temperature of the patient.

An application of a mitoxantrone preparation in preparation of a drug for diagnosing and treating a disease related to thyroidectomy, and use of mitoxantrone and/or a pharmaceutically acceptable salt thereof in preparation of a lymph tracer for preventing parathyroid gland staining in error, preventing parathyroid gland cutting in error, or reducing the rate of parathyroid gland cutting in error. Local injection of a mitoxantrone hydrochloride injection fluid would not cause parathyroid gland staining in error, and can reduce the rate of parathyroid gland cutting in error, thus protecting parathyroid glands well; moreover, no local or systemic toxic side effect is found after the local injection. The present invention has good tolerability, efficacy, and safety, and provides a new treatment idea in radically curing thyroid diseases thoroughly for patients suffering from diseases related to thyroidectomy.

The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. Aβ-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.

An ophthalmic composition comprising Indigo Carmine, or Indigo Carmine and Trypan Blue, for identification of intraocular structures and membranes within the eye, and methods of delivering and using the same, for surgical treatments of the eye, including glaucoma and cataract surgery.

The invention relates generally to the use of dyes to enhance visualization of tissues and boundaries of openings in tissues during cataract surgery.

The present invention describes methods of identifying, detecting, imaging, isolating and locating cancer cells in a subject. The method involves the use of near-infrared (NIR) organic carbocyanine dyes, particularly, near infrared heptamethine cyanine dyes and the detection of the fluorescence of these NIR dyes. The uptake of these dyes by cancer cells and not by normal cells, as well as their high intensity, among other things, allow for the detection of cancerous cells in a subject and facilitate their subsequent isolation. Further, detection of many tumor types and tumor cell populations under cell culture and in vivo conditions are described.

A composition for detecting biofilm on an eyelid margin includes a dye that binds to the biofilm and a solution that is biocompatible with the eye. A method for detecting biofilm on an eyelid margin of an eye includes applying a solution to the eye or the eyelid margin so that a dye in the solution binds to the biofilm. A handheld camera for detecting biofilm on an eyelid margin of an eye includes a housing, an image sensor, and a lens including a focal length determined by a distance between the lens and the eyelid margin. A method for detecting biofilm on an eyelid margin includes capturing an image of the eyelid margin using a handheld camera and determining if the biofilm is present on the eyelid margin. A system for detecting biofilm on an eyelid margin of an eye includes a composition and a handheld camera.

Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I). ##STR00001##

The present invention relates in general terms to an antimicrobial composition having chlorhexidine and a dye selected from 3,7-bis(dimethylamino)-phenothiazin-5-ium chloride and a sodium or calcium salt of [4-(α-(4-diethylaminophenyl)-5-hydroxy-2, 4-disulfophenylmethylidene)-2,5-cyclohexadien-1-ylidene] diethylammonium hydroxide usable in the medical field. In particular, the invention relates to the composition in the form of aqueous solution, hydro-alcoholic solution or gel, and its use as a coloring antiseptic and disinfectant agent, for example in pre-surgical procedures.

Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.