The present invention provides a high-content carotenoid compound from Adonis amurensis. The content of the total carotenoid of the carotenoid compound is higher than 95%. The content of all-trans (3S, 3′S)-carotenoid is higher than 80%. The carotenoid crystals have a high purity, and can be used in multiple forms in the fields of a dietary supplement of a human being, a food additive, a feed additive and a cosmetic product. In addition, the present invention also provides a method for manufacturing the compound.

The present disclosure relates to a composition that is capable of preventing hair loss and promoting hair growth by comprising the extract of the above-ground part of carrots. The composition comprising the extract of the above-ground part of carrots of the present disclosure significantly increases the viability of dermal papilla cells and can inhibit the expression of 5a-reductase, thereby exhibiting excellent effects in preventing hair loss and promoting hair growth.

A method of extracting natural products, such as cannabinoids, flavonoids and terpenes, from plant material such as a Cannabis genus of plant is disclosed. The method affords a quick and efficient extraction of natural products without further purification.

The invention concerns a plant extract obtained from saffron, with a safranal concentration, measured using the HPLC method, of a minimum of 0.2% in weight relative to the total dry matter weight. The invention also concerns a procedure for obtaining such an extract, as well as compositions including this extract, and its use.

The invention relates to an extract of Ashwagandha that exhibit enhanced bioactivity and bioavailability comprising of enriched withanolide glycosides and saponins; with negligible amount of alkaloids, withanolide aglycones and oligosaccharides. The extract as disclosed prepared from root, stems, leaves and whole plant of Ashwagandha further shows improved immunomodulatory activity, anti-inflammatory activity, anti stress activity, antidiabetic activity and sleep quality. The disclosure also provides a method of improving bioactivity of withanolide glycosides even at lower doses, by the administration of an enteric coaled formulation of extract of Ashwagandha to humans. The enteric coaling protects the composition from hydrolysis in the acidic environment of the stomach to release the withanolide glycoside in neutral/alkaline pH in gastrointestinal tract (GIT) thus enhancing the absorption. Further the process of preparation of the extract of Ashwagandha enriched with withanolide glycosides and saponins are disclosed along with various formulations.

The present invention is related to an active substance of Hericium erinaceus having a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium of H. erinaceus on an agar plate and incubating at 15-32° C. for 8-16 days; (b) inoculating the incubated H. erinaceus mycelia from step (a) into a medium in a flask and incubating at 20-30° C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubated H. erinaceus mycelia from step (b) into a medium in a fermentation tank and incubating at 24-32° C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of the H. erinaceus mycelia; and (d) desiccating the fermented medium of the H. erinaceus mycelia from step (c) to obtain the powder of the H. erinaceus mycelia, which is further purified and isolated to obtain a novel compound of H. erinaceus.

A cannabis composition includes a cannabis material and an additive solution. Cannabis material includes flowers, sugar leaves, and fan leaves from a cannabis plant, and can be configured to be finely cut or coarsely cut. An additive solution includes honey and a cannabis extract. Further disclosed is a method of manufacture of a cannabis composition, including a method for allowing a cannabis composition to ferment and a method of heating a cannabis composition.

Provided is a method of producing a purified chlorogenic acid-containing composition, including: a first step of dispersing or dissolving a raw material chlorogenic acid-containing composition in an aqueous solution of organic solvent; a second step of removing a precipitate from a dispersion or a solution obtained in the first step; and a third step of bringing a solution obtained in the second step into contact with activated carbon including activated carbon (A) having a pore volume of from 0.3 mL/g to 1.0 mL/g and activated carbon (B) having a pore volume larger than that of the activated carbon (A), in which a difference [(B)−(A)] in pore volume between the activated carbon (A) and the activated carbon (B) is from 0.1 mL/g to 1.5 mL/g.

A method of obtaining vitamin D from shiitake includes a) adding ethanol to shiitake powder, followed by reflux extraction, to prepare a shiitake extract; and (b) irradiating ultraviolet (UV) light to the shiitake extract prepared in step (a). When shiitake extracts are obtained and exposed to ultraviolet light under specific conditions, the content of vitamin D2 in the shiitake extracts may be increased.

This invention discloses nano-dimensional compositions of psychedelic drugs, entheogens, and medicinal mushrooms formed from lipids, polymers, stabilizers, mucoadhesives, permeation enhancers, and chemical stabilizers for delivering stable dosage forms by intraoral, gastrointestinal, transdermal, and intranasal, routes of administration. Disclosed are unified product extraction and manufacturing of stable nano-dimensional dosage forms of psychedelic drugs, entheogen, and medicinal mushrooms, and methods for improving their pharmacokinetics, pharmacodynamics, and efficacy. Also disclosed are methods for dephosphorylating the precursor psilocybin into active psilocin molecules, and fast-acting, nano-dimensional structures of psychedelic drugs taken by intranasal and intraoral routes of administration producing activity onset in less than 10 minutes.