A61K2236/35

COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY BOWEL DISEASE INCLUDING PUER TEA EXTRACT
20220409689 · 2022-12-29 ·

Provided is a method for preventing and alleviating inflammatory bowel disease by administering a composition including puer tea extract as an active ingredient to a subject in need thereof. Puer tea extract of the present disclosure showed an effect of improving damaged colonic tissue in a mouse model of acute ulcerative colitis induced by dextran sulfate sodium (DSS), and showed an inhibitory effect on clinical symptoms of the disease activity index (DAT) of weight loss, diarrhea, and rectal bleeding. In addition, puer tea extract inhibited the expression of inflammatory cytokines TNF-α and IL-6 in the colonic tissue and inhibited the inflammatory response through inhibition of the activity of NF-κB, an anti-inflammatory mechanism. In addition, the DPPH free radical and ABTS free radical scavenging ability increased proportionally as the concentration of puer tea extract increased at the cellular level, and COX-2 expression was inhibited in LPS-activated macrophages.

ANTIOXIDANT AND ANTIMICROBIAL COMPOSITIONS AND METHODS OF USING THEM TO PROTECT SKIN OR TREAT OR PREVENT INFECTIONS
20220387534 · 2022-12-08 ·

Compositions and methods of using them to protect an animal cell or tissue from a microbial pathogen are described. The compositions can include one or more natural oils or extracts comprising a therapeutically active compound to protect the cell or tissue of the animal from the microbial pathogen by direct inactivation of the microbial pathogen or by blocking the microbial pathogen entrance to the animal cell or tissue. Oil macerates that include a therapeutically active compound extracted from plants are also described.

Plant extract highly concentrated in safranal, production method and uses thereof

A plant extract obtained from saffron, with a safranal concentration, measured using the HPLC method, of a minimum of 0.2% by weight relative to the total dry matter weight. A method for obtaining the plant extract, as well as compositions comprising the plant extract, and methods of treatment.

COMPOSITION FOR ANTI-OXIDATION AND ANTI-INFLAMMATION COMPRISING SALVIA PLEBEIA R BR EXTRACT AND CENTELLA ASIATICA EXTRACT
20230059068 · 2023-02-23 ·

The present invention relates to a composition for anti-oxidation and anti-inflammation, comprising a Salvia plebeia R. BR. extract and a Centella asiatica extract as an active ingredient. The composition exhibits a radical scavenging ability, and has excellent antioxidant, anti-inflammatory and anti-itching effects by significantly inhibiting inflammation and itch-inducing factors at gene and protein levels, and thus can be advantageously used as a cosmetic composition for anti-oxidation and anti-inflammation.

MEDICINAL AMBROSIA MARITIMA EXTRACTS

Phytoceutical compositions from polar organic extracts of the Ambrosia maritima plants and uses thereof for treatment of coronavirus infections are described.

Cosmetic or dermatological preparation containing an aqueous and a lipophilic fish egg extract
11491191 · 2022-11-08 · ·

A cosmetic or dermatological preparation that contains an aqueous and a lipophilic fish egg extract for replumping skin; for increasing the incorporation of triglycerides in adipocytes; for increasing the expression of laminin, preferably of laminin-5 and most preferably of laminin-5 β sub-unit; and/or for maintaining the skin elasticity and/or resilience of human skin.

NOVEL COMPOSITION BASED ON POLYCAFFEOYLQUINIC ACIDS, COSMETIC USE THEREOF AND COSMETIC COMPOSITIONS COMPRISING SAME

Disclosed is a composition including, per 100% of its mass: a) 60.0% to 75.0% by mass of an organic solvent (OS.sub.1) chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a mixture of these compounds; b) 0.1% to 2.0% by mass of a composition (ES) including an amount by mass x.sub.1, expressed as mass equivalent of 1-O-(2-caffeoyl)maloyl-3,5-di-O-catfeoylquinic acid, of greater than or equal to 200 mg/g of a compound of general formula (I):

##STR00001##

in which Q.sub.1, Q.sub.2, Q.sub.3, Q.sub.4 and Q.sub.5 represent, independently of each other, a hydroxyl radical or a salt thereof or a radical chosen from caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals, it being understood that at least one of these radicals Q.sub.1, Q.sub.2, Q.sub.3, Q.sub.4 and Q.sub.5 represents neither the —OH radical nor a salt thereof; and c) 20.0% to 35.0% by mass of water. Related treatments are also disclosed.

A TOPICAL COMPOSITION COMPRISING AN EXTRACT OF COMBINED HERBS COMPRISING LONGANAE ARILLUS FOR TLSP INHIBITION AND THE TREATMENT OR ALLEVIATION OF SKIN INFLAMMATORY DISEASE AND THE USE THEREOF
20230100173 · 2023-03-30 ·

The present invention is related to a topical pharmaceutical composition and cosmetic composition comprising a combined herb extract of Longanae Arillus, Ligustici Tenuissimi Rhizoma and Polygalae radix as an active ingredient to inhibit TLSP (thymic stromal lymphopoietin) cytokine expression or to treat and alleviate skin inflammatory diseases.

THE USE OF UNRIPENED GREEN MANGIFERA INDICA AS A NATURAL PREPARATION TO TREAT SARS-COV-2

The present disclosure provides a method for an effective decoction preparation of unripe green Mangifera indica to treat and prevent anti-SARS-CoV-2. The disclosure extends to uses of such preparation as medicaments and to methods of treating anti-SARS-CoV-2 infections, and tolerating the vaccine side-effects. The disclosure further extends to methods for preventing anti-SARS-CoV-2 infections by coating objects and surfaces with the compositions.

SOLVENTS, METHODS, AND SYSTEMS FOR ISOLATING BOTANICAL EXTRACTS FROM PLANTS
20230036925 · 2023-02-02 ·

The present invention provides improved solvents, methods, and systems for isolating purified cannabinoids from various sources. It has been found that C.sub.9 to C.sub.11 non-aromatic hydrocarbon solvents, and especially n-decane, work surprisingly well for crystallization of cannabinoids such as cannabidiol. Some variations provide a method of isolating cannabinoids from a cannabinoid-containing solution, comprising contacting the solution with a C.sub.9-C.sub.11 non-aromatic hydrocarbon solvent (e.g., n-decane) at a first temperature, to generate a mixture; cooling the mixture to precipitate cannabinoids; and isolating the precipitated cannabinoids. Other variations provide a method of isolating cannabinoids from a cannabinoid-containing solution, comprising contacting the solution with a C.sub.9-C.sub.11 non-aromatic hydrocarbon solvent (e.g., n-decane) at a first temperature below the solvent boiling point, to generate a mixture; subjecting the mixture to a second temperature that causes vaporization of the solvent, to precipitate at least some of the cannabinoids; and isolating the precipitated cannabinoids.