The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

A beauty care method has a step of applying an aqueous pack agent 1 containing water, a magnetic powder 11, a thickener and a charged iontophoretic component 13 to the skin 2; a step of applying magnetic force to the magnetic powder 11 in the aqueous pack agent 1 applied to the skin 2 to attract and remove the magnetic powder 11 from the skin surface 21 by the magnetic force while leaving an aqueous solution 12 of the iontophoretic component on the skin surface 21; and a step of applying an iontophoretic current to the skin 2 with the aqueous solution 12 left to allow the iontophoretic component 13 to infiltrate into the skin.

Provided is a method for forming a good fibrous coating on a target surface even in a high-humidity environment when electrostatically spraying is performed directly on the target surface such as skin.

A composition for forming a coating of fibers on a target object by electrostatic spraying, comprising the following components (a), (b), (c) and (d): (a) 1 mass % or more and 45 mass % or less of a polymer having a film-forming ability; (b) 45 mass % to 95 mass % of one or more volatile substances selected from the group consisting of an alcohol and a ketone; (c) a conductivity controlling agent to control the conductivity of the composition to 8 S/cm or more and 300 S/cm or less; and (d) 0.2 mass % or more and 25 mass % or less of water.

Redox signaling gels are disclosed. Such gels include a composition with at least one reactive oxygen species (ROS) and a rheology modifier. Also presented herein is a process for making the gels which includes making the composition by taking the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of 4.3 to 5.8 C. such that the electrolyzing is accomplished with an anode, cathode and power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor.

Devices and methods for styling hair, and in particular, to devices and methods for styling hair using electrolysis are described herein. A method for styling hair includes arranging a section of hair between a first electrode and a second electrode. The section of hair is contacted with an electrolyte before being arranged between the first and second electrodes, after being arranged between the first and second electrodes, and/or concurrently with being arranged between the first and second electrodes. The method further includes causing the first electrode to have a first negative potential, and causing the second electrode to have a second potential, such that the absolute value of the first negative potential is greater than the absolute value of the second potential, and such that the difference in electrical potential between the first electrode and the second electrode creates an electrolysis zone between the first electrode and the second electrode.

The coating formation method of the present invention is a method for forming a coating on a surface of a coating formation target. The formation method of the present invention includes an electrostatic spraying step of electrostatically spraying a composition directly onto the coating formation target, thereby forming a coating composed of a deposit containing fibers. The composition contains a component (a), a component (b), and a component (c) below. (a) One or more volatile substances selected from water, alcohols, and ketones. (b) A polymer having coating formability. (c) A liquid agent containing one or more selected from oils and polyols that are in a liquid form at 20 C.

Described herein are compositions that include a saline solution and reactive oxygen species. Specifically, the composition may include a saline solution, reactive oxygen species, an emollient, and a pH modifier. Also provided is a gel composition that includes a rheology agent. Also provided are methods of making and using the compositions.

The present invention generally relates to deuterium-enriched hyaluronan, d-HA, compositions containing the same, methods of using the same, and methods for making the same. ##STR00001##

Method for loading various molecules into plant-derived nanovesicles, comprising the following steps: a. suspending the isolated nanovesicles in a phosphate buffered saline; b. analyzing the suspended nanovesicles with a technique called Nanoparticle Tracking Analysis using a Nanosight for the evaluation of concentration and size distribution; c. re-suspending the nanovesicles in phosphate buffered saline; d. transferring the nanovesicles to sterile means; e. adding the fluorescent chemical to be loaded; f. treating the nanovesicles in the sterile means to facilitate the entry of the molecule to be loaded through their cell membrane; g. transferring the nanovesicles loaded with the desired molecule into ultra?centrifuge tubes; h. re-suspending the pellet containing the nanovesicles in phosphate buffered saline and storing the supernatant obtained from the ultracentrifugation as a control for subsequent analysis; i. re-suspending the nanovesicles in phosphate buffered saline and proceed with testing.

A product container is provided. The product container includes a first product and an electrochemistry device configured to convert a portion of the first product into a second product, which is an unstable formulation.