The present invention concerns a method to prepare a filler with a hyaluronic acid, which has improved properties of chemical-physical stability over time and optimal viscosity for cutaneous injection. In particular the method comprises a first step in which the hyaluronic acid is crosslinked, and a subsequent step for the neutralization and hydration of the crosslinked hyaluronic acid.

The lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to stabilize stem cell-derived exosomes and exhibit excellent anti-inflammatory effects, and particularly, exhibit remarkable anti-inflammatory effects as compared with not-lyophilized stem cell-derived exosomes isolated and purified from conditioned media of stem cells. Therefore, the lyophilized formulation of stem cell-derived exosomes and the anti-inflammatory composition including the same as an active ingredient is able to effectively prevent, suppress, alleviate, ameliorate or treat inflammatory response or inflammatory diseases.

The present invention relates to a hyperbranched polyglycerol polyglycidyl ether having a molecular weight from 750 to 15.000 Da; and an epoxy equivalent weight from 183 to 7.000 g/eq. It also relates to a crosslinked polysaccharide obtainable by crosslinking the polysaccharide with the hyperbranched polyglycerol polyglycidyl ether. The present invention also relates to processes for their preparation and their uses in therapy, cosmetic, agriculture and food field.

Improved dermal filler formulation comprising a hyaluronic acid and a botulinum toxin.

The invention relates to the use of an animal-protein-free botulinum toxin composition to treat a disease, disorder or condition in a patient in need thereof whereby the animal-protein-free botulinum toxin composition exhibits a longer lasting effect in the patient compared to an animal-protein-containing botulinum toxin composition.

The present disclosure relates to a polycaprolactone microsphere containing vitamin C, a filler including the same and a preparation method therefor. Provided is a polycaprolactone microsphere filler obtained by encapsulating vitamin C in polycaprolactone microspheres, which, when injected into a living body, exhibits a rapid collagen formation effect as well as a high tissue restoration property and maintains the effects for a long period of time, thereby showing excellent restoration or volume expansion or wrinkle improvement properties of soft tissues such as cheeks, breasts, nose, lips, and buttocks and reducing wrinkles.

Provided is a kit or system (100) for preparing a peroxide composition with increased viscosity with a pH in the range of 7 to 12 in an almost instantaneous method. For example, the kit or system may be used to provide an almost instantly obtainable (hydro)gelled peroxide composition. The system comprises a first aqueous composition (102) comprising a peroxide agent. The first aqueous composition has a first pH of less than 7. The system further comprises a second composition (104) comprising a basic agent. The second composition is separate from the first aqueous composition. A pH induced thickener is included in the kit or system separate from the second composition. The peroxide composition is obtainable by combining the parts of the kit or system. The pH induced thickener is capable of increasing the viscosity of the peroxide composition upon subjecting it to the pH in the range of 7 to 12. The kit or system has sufficient basic agent for the peroxide composition to cause the pH in the range of 7 to 12. A method for preparation and use of the kit or system is also provided.

Injectable prolonged-action compositions for use in the treatment of nail diseases, including potentially promoting the growth of the nail, or for use promoting the growth of the nail. The compositions are administered subcutaneously, and optionally as an implant. The compositions may be in solid or non-solid form and include one or more solid biodegradable sustained-release polymers, and optionally one or more active substances.

Methods for promoting hair growth, and needling devices for use with such methods, are provided. Certain of the methods include disruption of the skin with a powered needling device, followed by an administration of a hair growth-promoting agent.

The present invention relates to a multi-postbiotics-compounded rejuvenating essence, which includes the following components in percentage by weight: 8.0-13.0% of butanediol, 2.0-3.0% of triglyceride octoate/caprate/succinate, 2.0-3.0% of polyglutamate sodium, 0.5-1.0% of extract of Japanese Ardisia herb stems, 0.5-1.0% of yeast/rice ferment filtrate, 0.5-1.0% of fission yeast mycelium ferment filtrate, 0.5-1.0% of lactobacillus/mung bean extract/sodium glutamate ferment filtrate, 0.5-1.0% of lactobacillus ferment, 0.5-1.0% of bacillus/rice bran extract/soybean extract ferment filtrate, 0.5-1.0% of Streptococcus thermophilus ferment, 0.1-0.2% of collargol, and 65.3-79.4% of deionized water, wherein the essence is put in an airtight container and is injected with hydrogen. The present invention can achieve an effect of repairing the skin, and the combination of active substances with the hydrogen injected has a prominent effect on reducing the amount of allergic erythema and alleviating the recurrent allergic redness and rashes.