Disclosed herein are methods of restoring elasticity in tissue using tropoelastin containing compositions.

The present invention provides a gel for injection containing controlled degradation polyester microspheres. The gel for injection consists of crosslinked sodium hyaluronate gel, non-crosslinked sodium hyaluronate gel, polyester microspheres wrapped with hard fat and a balanced salt solution. The polyester microspheres are separated from water by means of wrapping and hydrophobic effect of the hard fat, and accordingly the present invention solve the problem that polyester materials are prone to degradation in gel. In the meantime, the hard fat has the characteristic of low melting point (melting point being 33° C.-39° C.), after the product is injected into human body, the hard fat is molten and separated under the action of human body temperature, and the wrapped polyester microspheres are released so that the microspheres can be degraded in the human body to achieve controlled degradation.

A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.

A hyaluronic acid-based aqueous gel including crosslinked hyaluronic acid and from 30 to 70% by mass with respect to the total mass of hyaluronic acid, of a water-soluble hyaluronic acid. A method for preparing an aqueous gel having at least a crosslinked hyaluronic acid and at least an uncrosslinked hyaluronic acid. Also an aqueous gel obtainable by the method compositions, a cosmetic and/or dermatological composition including the aqueous gels, and a kit comprising a pre-filled syringe comprising the aqueous gel or said composition. These gels and compositions are useful in particular for treating an alteration in the surface appearance of the skin and/or for augmenting and/or filling soft tissue.

Provided is a new means for administering a valuable substance having a fat dissolving action. A microneedle preparation including at least one of a lipolytic agent, a fat dissolving agent, or a fat metabolism promoting agent, the microneedle preparation being intended for fat reduction and/or partial slenderizing and/or skin tightening, and a microneedle preparation including a microneedle array containing a water-soluble polymer as a base and one or more selected from the group consisting of a lipase, a phosphatidylcholine, and deoxycholic acid.

Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.

Hyaluronic acid and silk fibroin or silk fibroin fragments tissue fillers and methods of making and using the same are provided herein. In some embodiments, the disclosure relates to a biocompatible tissue filler comprising silk fibroin or silk fibroin fragments, hyaluronic acid (HA), and polyethylene glycol (PEG) and/or polypropylene glycol (PPG), wherein a portion of the HA is modified or crosslinked by one or more linker moieties comprising one or more of polyethylene glycol (PEG), polypropylene glycol (PPG), and a secondary alcohol, wherein the linker moieties are attached to the HA at one end of the linker.

Disclosed are injectable dermo-aesthetic formulations comprising aqueous solutions of at least one unmodified high-molecular-weight linear hyaluronic acid or hyaluronate and at least one unmodified low-molecular-weight linear hyaluronic acid or hyaluronate or non-sulphated chondroitin. The compositions according to the invention are useful as fillers with an excellent safety profile, adequate residence time at the site of application, and limited extrusion force.

Disclosed herein are aesthetic-enhancing formulations and methods thereof. For example, an aesthetic-enhancing formulation includes, in some embodiments, one or more pigments, one or more active ingredients, and one or more excipients. The one-or-more excipients includes at least a vehicle configured to evenly distribute components throughout the aesthetic-enhancing formulation, the components including the one-or-more pigments, the one-or-more active ingredients, and any other excipients other than the vehicle. In another example, a method for the aesthetic-enhancing formulation includes, in some embodiments, inserting the aesthetic-enhancing formulation into a dermal layer of skin by percutaneous punctures.

A person's iris color can lighten, such as from brown to lighter brown, green, hazel, or blue, by introducing a melanocyte-killing agent through the cornea of the person's eye and contacting the anterior surface of the iris with the agent at a dose sufficient to kill melanocytes in the iris stroma.