An antibacterial medical biomaterial includes an acellular small intestinal submucosal matrix material, an antibacterial gel layer located on a surface of the acellular small intestinal submucosal matrix material, and an absorbable fiber layer located on a surface of the antibacterial gel layer. Sulfadiazine silver is on the surface of the acellular small intestinal submucosal matrix material and/or within the acellular small intestinal submucosal matrix material. An absorbable fiber layer to which the sulfadiazine silver is attached, wherein the content of sulfadiazine silver in the absorbable fiber is 1 wt. %˜2 wt. %. The medical biomaterial is usable as an external medicine for treating wound infections relayed by burns or wounds, and for reducing the incidence of infection by using a conventional central venous catheter with a sulfadiazine silver antibacterial coating, so that the medical biomaterial loaded with sulfadiazine silver also has antibacterial activity consistent with sulfadiazine silver.

A device includes a shell including a proximal end and a distal end of the shell. The device also includes a plunger within the shell. The plunger can include a flexible stop at a proximal end of the plunger and a distal end. The device can further include an absorptive unit configured to absorb fluid within a vaginal cavity. The absorptive unit can be affixed to the distal end of the plunger. The absorptive unit can include an absorptive element affixed to a frame structure configurable to reversibly transition between a compressed and uncompressed configuration. The absorptive unit can also include a tether coupled to the absorptive unit via the frame structure. The tether can extend through the proximal end of the plunger. Related methods of use are also described.

A device includes a shell including a proximal end and a distal end of the shell. The device also includes a plunger within the shell. The plunger can include a flexible stop at a proximal end of the plunger and a distal end. The device can further include an absorptive unit configured to absorb fluid within a vaginal cavity. The absorptive unit can be affixed to the distal end of the plunger. The absorptive unit can include an absorptive element affixed to a frame structure configurable to reversibly transition between a compressed and uncompressed configuration. The absorptive unit can also include a tether coupled to the absorptive unit via the frame structure. The tether can extend through the proximal end of the plunger. Related methods of use are also described.

Particles made of a viscoelastic medium, are injectable gel particles, and have a size, when subjected to a physiological salt solution, in the range of from 1 to 5 mm. The particles are useful in a soft tissue augmentation implant. The implant includes particles of a viscoelastic medium, wherein a major volume of the particles are injectable gel particles The implant is useful in a method of soft tissue augmentation in a mammal, including man, comprising subepidermal administration at a site in said mammal where soft tissue augmentation is desirable, of an implant.

Particles made of a viscoelastic medium, are injectable gel particles, and have a size, when subjected to a physiological salt solution, in the range of from 1 to 5 mm. The particles are useful in a soft tissue augmentation implant. The implant includes particles of a viscoelastic medium, wherein a major volume of the particles are injectable gel particles The implant is useful in a method of soft tissue augmentation in a mammal, including man, comprising subepidermal administration at a site in said mammal where soft tissue augmentation is desirable, of an implant.

Glucocorticoid-induced leucine zipper protein (GILZ) peptide compositions and their methods of use in wound healing are disclosed herein. An exemplary GILZ peptide composition includes a GILZ fusion protein. The GILZ peptide compositions can be administered topically to wounds, for example in the form of a cream, ointment, or lotion. The GILZ peptide compositions can be used to treat acute wounds, induce wound healing in chronic wounds, and reduce scar formation.

A surface is covered with microstructures that extend from the surface, and are made of a resilient material that allows the microstructures to bend or articulate. The microstructures are generally columnar and can have fingers on their distal or top end that is opposite the base from which the microstructures extend. In addition to the ordinary roughness presented by the microstructures, the articulation further discourages biofouling and bioadherence. The articulation of the microstructures can be oriented, and the orientations can be mixed or varied among the microstructures so that adjacent ones of the microstructures have different orientations of articulation.

A surface is covered with microstructures that extend from the surface, and are made of a resilient material that allows the microstructures to bend or articulate. The microstructures are generally columnar and can have fingers on their distal or top end that is opposite the base from which the microstructures extend. In addition to the ordinary roughness presented by the microstructures, the articulation further discourages biofouling and bioadherence. The articulation of the microstructures can be oriented, and the orientations can be mixed or varied among the microstructures so that adjacent ones of the microstructures have different orientations of articulation.

The present invention discloses a method for increasing absorbent capacity of a superabsorbent material (SAM) by treating the SAM with a selected salt or a combination of such salts. The selected salt(s) may interact with the polymer chain of the SAM through one or more absorbent capacity enhancement mechanisms. The absorbent capacity enhancement mechanism(s) between selected salt(s) and the SAM may lead to greater absorbent capacity of the SAM.

Dressings for treating a tissue site with negative pressure are disclosed, which may include a dressing having a manifold and a contact layer. In some embodiments, the manifold may comprise a plurality of holes, a first side, a second side, and a perimeter side between the first side and the second side. The contact layer may comprise collagen applied to the first side of the manifold and a perimeter side of the manifold. The plurality of holes of the manifold may include a center hole and a plurality of peripheral holes arranged around the center hole.