This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.

The present invention provides a modified collagen comprising S-nitroso groups and a method of manufacture of such a modified collagen. Also provided is a wound dressing comprising such a modified collagen, particularly a wound dressing comprising a formulated composition comprising such a modified collagen.

The present invention provides a hemostatic porous composite sponge comprising i) a matrix of a biomaterial; and ii) one hydrophilic polymeric component comprising reactive groups wherein i) and ii) are associated with each other so that the reactivity of the polymeric component is retained, wherein associated means that said polymeric component is coated onto a surface of said matrix of a biomaterial, or said matrix is impregnated with said polymeric material, or both.

The invention relates to a compression bandage comprising a nonwoven-based bandage layer that has been stitched over with elastic textile threads by stitch bonding methods, the textile threads being heat-shrinkable and not elastomeric and the compression bandage having an elasticity after heat shrinking of the textile threads by 50-200%, particularly 50% to 90% and especially 50% to 70%. The invention also relates to a compression bandage combination.

Devices for delivering a flowable tissue dressing material for treating a tissue site are described. The devices include a first zone including a first reactant, such as a polyol, and a second zone including a second reactant, such as a multi-isocyanate, which can be mixed together to form a flowable tissue dressing material. The device can also include a flowable tissue dressing material including a reacted polymer present in a carrier. Kits and methods including and/or using the devices are also described.

The present disclosure relates generally to wound dressing compositions and methods of manufacturing the wound dressing compositions of the present technology. The wound dressing composition includes a mixture of a collagen and/or chitosan and oxidized regenerated cellulose (ORC) with a layer of citric acid disposed therein. Also disclosed herein are methods of manufacturing such wound dressing compositions as well as kits including such wound dressing compositions.

The present disclosure provides wound dressing compositions that disrupt biofilm formation in a wound upon application. The wound dressing composition includes a first layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), and at least one bacteria reducing active ingredient and a second layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), a silver compound, and at least one bacteria reducing active ingredient, and the uses thereof. Also disclosed herein are kits comprising the wound dressing compositions of the present technology, and instructions for use.

The present disclosure provides wound dressing compositions that disrupt biofilm formation in a wound upon application. The wound dressing composition includes a first layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), and at least one bacteria reducing active ingredient and a second layer comprising a homogeneous mixture of a collagen, an oxidized regenerated cellulose (ORC), a silver compound, and at least one bacteria reducing active ingredient, and the uses thereof. Also disclosed herein are kits comprising the wound dressing compositions of the present technology, and instructions for use.

Interpenetrating network hydrogels with independently tunable stiffness enhance tissue regeneration and wound healing.

Methods and (articles of manufacture therefrom) including forming an elastic film from a polymer composition; tensioning the elastic film to a stretch ratio of between 2 and 6 in the MD; laminating the elastic film to an extensible facing to provide an elastomeric laminate having a CD hysteresis loss of 70% or less and an MD hysteresis loss of 50% or less.