A plaster preparation includes (a) at least one resorbable polymer made of at least three monomer units, in particular a terpolymer, having monomers selected from the group consisting of trimethylene carbonate, glycolide, lactide (in particular DL-lactide), p-dioxanone, ε-caprolactone and/or butyrolactone; (b) at least one readily vaporizable organic solvent; and (c) at least one propellant. The plaster preparation additionally relates to a polymer film, to a spray plaster spray device, to a method for producing polymer fiber nonwoven materials, to a polymer fiber nonwoven material, and to uses of the plaster preparation.

A gel is to be disclosed, in particular for use in a wound treatment composition, with which a particularly high storage stability and long-term stability can be achieved with high microbiocidal activity. For this purpose, the gel according to the invention comprises an inorganic silicate as thickener and an electrochemically activated starting saline solution which has a free chlorine content of more than 300 mg/l. In addition, a colored gel having the properties described above can be obtained by adding suitable pigments.

A preparation method of calcium peroxide-mediated in situ crosslinkable hydrogel as a sustained oxygen-generating matrix, includes: a) reacting a natural or a synthetic polymer with Traut's reagent (TR) in a solvent, and synthesizing a polymer derivative having thiol group in backbone of the polymer derivative; and b) mixing and reacting a solution of the polymer derivative having thiol group with calcium peroxide (CaO.sub.2), and thereby forming a hydrogel, wherein in the step b), disulfide bonds (—S—S) are induced between backbones of the polymer derivative having thiol group attached by decomposition of calcium peroxide (CaO.sub.2), and thereby in situ crosslinking is formed.

The present invention relates to a hemostatic absorbable composition, comprising: a flowable plurality of separate aggregates each comprising: a plurality of absorbable carrier particles coated on a surface thereof by a plurality of smaller particles comprising an absorbable supplemental hemostasis-promoting agent. In some embodiments, the absorbable carrier particles comprise gelatin or collagen, and the supplemental hemostasis-promoting agent comprises oxidized cellulose, oxidized regenerated cellulose, carboxylic oxidized cellulose, carboxylic oxidized regenerated cellulose, thrombin, or tranexamic acid.

Nanoparticulate, ion-paired complexes of melittin (MLN) and one or more non-steroidal anti-inflammatory drugs, and particularly MLN ion-paired with diclofenac, provide for enhanced wound healing in humans and other animals. Compositions having the nanonparticulates distributed therein or thereon are applied topically to the wound, and the ion-paired complexes have been shown to demonstrate superior wound healing and closure.

One aspect of the invention provides a method of treating a chronic wound including administering to the wound at least one agent from a delivery system wherein the agent induces sequential conversion of a first population of wound macrophages in the wound to M2A macrophages and a second population of wound macrophages to M2C macrophages. The sequential conversion of the wound macrophages promotes tissue remodeling.

In some embodiments, a film forming composition described herein comprises an aliphatic polyisocyanate; an aliphatic polyfunctional nucleophile; a chain extender; a first solvent; and a second solvent, wherein an evaporation rate of the first solvent and an evaporation rate of the second solvent are within 150% of each other, the percentage being based on the larger value. In some embodiments, a method of forming a film on a substrate is described herein, the method comprising combining a polyisocyanate with a polyol to form a polyurethane pre-polymer; combining the polyurethane pre-polymer with a chain extender to form a polymer; and applying the polymer to the substrate.

The invention provides a composition and pharmaceutical formulation including a peptide immobilized in a hydro gel. Compositions and formulations of the invention are useful in reducing the size, severity or duration of a wound, ameliorating of one or more symptoms associated with a wound without necessarily curing the wound, or lessening in the growth or severity of a wound. Compositions and formulations of the invention are particularly useful in the treatment of a wound associated with diabetes, such as a diabetic ulcer.

Methods and compositions for reducing a ratio of collagen III to collagen I in wounded skin, treating wounds and accelerating healing is provided with a surfactant polymer dressing comprising FL2 siRNA, collagen and a poloxamer.

An improved dressing is presented which enables quicker wound closure and a lower anesthesia requirement, comprised of an improved prior-art skin-substitute. The improvements consist of variations in the thickness of the woven portion of the dressing, to increase wound adherence.