The invention relates to biomaterials based on plastics, such as polyaryl polyether ketone (PEK), and to methods for producing and using same. The following describes how a mechanically stable coating made of a porous bone substitute material, e.g. Nano Bone®, is applied to polyaryl polyether ketone (PEK), e.g. polyether ether ketone (PEEK), as a result of which the problem of poor cell adhesion on plastics surfaces of this kind can be solved. The bone substitute material can be applied both dry as a powder and also in a wet spraying method. The coating is a result of briefly melting the polymer surface and the resulting partial penetration of the previously applied layer. In the process, the molten polymer penetrates into nanopores of the bone substitute material and thus establishes a firm connection.

Disclosed is a graft for a biological tube including a graft having a hollow of a specific length, having openings at opposite ends along a lengthwise direction thereof, and being contractible, and the graft is contracted to be adhered to outer peripheral surfaces of biological tubes when heat is applied to the graft in a state, in which portions of the biological tubes are inserted into the openings of the graft.

Provided herein are methods for preparing a metal matrix composite material by a deposition process. The metal matrix composite materials described herein are useful for anti-inflammatory, antibacterial, antifungal and viricidal applications.

The present disclosure provides a method for modifying a hydrogel lubricating coating on a surface of general equipment, and hydrogel lubricating coating-modified general equipment, belonging to the technical field of material surface modification. In the present disclosure, by combining catechol adhesion chemistry and free radical polymerization initiated by surface catalysis, the method can realize in-situ generation of free radicals at an interface of a substrate and a hydrogel monomer solution at room temperature, without external auxiliary conditions such as illumination or heating. The method can prepare the hydrophilic hydrogel lubricating coating on the surface of almost all existing substrates, which is especially suitable for lubricating modification on an inner surface of a non-translucent pipeline instrument, showing material versatility. Therefore, the method is suitable for the fields of surface engineering and biomedicine.

The present disclosure provides a method for modifying a hydrogel lubricating coating on a surface of general equipment, and hydrogel lubricating coating-modified general equipment, belonging to the technical field of material surface modification. In the present disclosure, by combining catechol adhesion chemistry and free radical polymerization initiated by surface catalysis, the method can realize in-situ generation of free radicals at an interface of a substrate and a hydrogel monomer solution at room temperature, without external auxiliary conditions such as illumination or heating. The method can prepare the hydrophilic hydrogel lubricating coating on the surface of almost all existing substrates, which is especially suitable for lubricating modification on an inner surface of a non-translucent pipeline instrument, showing material versatility. Therefore, the method is suitable for the fields of surface engineering and biomedicine.

A composition and medical implant made therefrom, the composition including a thick diffusion hardened zone, and preferably further including a ceramic layer. Also provided are orthopedic implants made from the composition, methods of making the composition, and methods of making orthopedic implants from the composition.

A composition and medical implant made therefrom, the composition including a thick diffusion hardened zone, and preferably further including a ceramic layer. Also provided are orthopedic implants made from the composition, methods of making the composition, and methods of making orthopedic implants from the composition.

Antimicrobial metal ion coatings. In particular, described herein are coatings including an anodic metal (e.g., silver and/or zinc and/or copper) that is co-deposited with a cathodic metal (e.g., palladium, platinum, gold, molybdenum, titanium, iridium, osmium, niobium or rhenium) on a substrate (including, but not limited to absorbable/resorbable substrates) so that the anodic metal is galvanically released as antimicrobial ions when the apparatus is exposed to a bodily fluid. The anodic metal may be at least about 25 percent by volume of the coating, resulting in a network of anodic metal with less than 20% of the anodic metal in the coating fully encapsulated by cathodic metal.

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.