The claimed method for performing ophthalmosurgical operations includes forming a recipient bed and implanting an autograft consisting of a portion of the patient's own nail plate, which is shaped to fit the recipient bed, and which is sterilized and then kept in a dry environment prior to implantation. The autograft is similar in chemical composition and physical characteristics to the tissues of the eye, is not accompanied by an immune system rejection reaction, and adapts to the shape of the recipient bed as a result of natural swelling.

The present disclosure relates to surgical grafts for replacing nipples and areolas lost to disease or trauma with surgical grafts of decellularized donor nipples and areolas and to placing and recellularizing such grafts. The disclosure further provides methods for decellularizing epidermis. The decellularized epidermis can be used as a protective cover for skin wounds.

A method for preparing tissue, in particular pericardial tissue, in particular for a heart valve prosthesis, the method including: decellularizing the tissue; subjecting the decellularized tissue to a cross-linking solution including glutaraldehyde; subjecting the tissue to a shape- and structure-stabilizing step, in which the tissue is exposed to a first solution containing glycerol and is exposed to a second solution containing polyethylene glycol; and drying the tissue after the shape- and structure-stabilizing step.

A system for preparation of an implant and ab interno insertion of the implant into an eye including a handle having one or more actuators and an elongated shaft having an outer sheath and an elongate member positioned within a lumen of the tubular outer sheath. The system includes a recess sized for holding a patch of material fixed relative to the handle and a cutting member movable relative to the handle and to the recess. The cutting member cuts the patch of material into an implant as the cutting member moves towards a cutting configuration. The implant, once cut, is axially aligned with the lumen of the tubular outer sheath. The inner elongate member is movable relative to the tubular outer sheath to advance the implant into a deployment position in the lumen of the tubular outer sheath for delivery into the eye. Related devices and methods are provided.

A cornea, which is ex vivo genetically manipulated in order not to elicit an immune response in an allogeneic recipient. The cornea is isolated, for use in transplantation and a method for production of a cornea, which is performed on an initial ex vivo, e.g. isolated cornea, for use in transplantation, e.g. for use in the treatment of cornea defects.

The invention relates to a preserved amniotic membrane, in particular a vacuum-dried amniotic membrane. It also relates to uses of vacuum-dried amniotic membrane and methods for making a vacuum-dried amniotic membrane. A method of processing an amniotic membrane to provide a vacuum-dried amniotic membrane, comprising the step of vacuum-drying the amniotic membrane Amniotic membrane (AM) is the inner most extraembryonic membrane that surrounds the foetus in a sac of amniotic fluid, functioning as a protective barrier to ascending infection and trauma during pregnancy.

The present invention provides compositions for treating soft tissue injuries comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix. Methods of making and using compositions comprising a collagen matrix and mesenchymal stem cells adhered to the collagen matrix are also provided.

A method for manufacturing a cardiac valve prosthesis is disclosed. This method comprises the following steps: a) shaping human or animal body tissue in a shaping process to give the body tissue a shape of a cardiac valve, and b) fixation and stabilization of the body tissue by a cross-linking agent, thereby preserving the shape given to the body tissue by the shaping process and thus obtaining a cardiac valve prosthesis. Furthermore, a method of implanting an autologous or allogenic cardiac valve prosthesis to an individual in need thereof is disclosed.

The present invention provides an implantable medical product in a pouch structure, comprising an extracellular matrix (ECM) structure in sheet form. The pouch structure has an internal region and is configured to receive an electrical medical device therein. In particular, a larger pouch structure is designed to accommodate a medical device having a larger size, such as a subcutaneous implantable cardioverter-defibrillators (S-ICDs). In particular, lock-stitched seamed ECM sheets form a larger pouch structure. It is preferable that the stitches can securely hold the ECM sheets together by providing mechanical strength and durability to withstand the weight of the electronic medical device. The stitches securely hold the pouch structure together and does not fall apart during trimming or cutting of the pouch structure.

The present invention is an improved implant made from regenerative tissue or natural tissue, methods of making the implant, and methods of using the implant.