Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

The invention relates to an implant material for filling bone defects, for bone regeneration, and for bone tissue engineering, to an implant comprising said material, and to methods for manufacturing such an implant. The hybrid implant material according to the invention comprises: a biodegradable polymer P soluble in at least one solvent S1 and insoluble in at least one solvent S, different from the solvent S1; and a bioactive glass made of SiO.sub.2 and CaO and optionally containing P.sub.2O.sub.5 and/or optionally doped with strontium, characterized in that said implant includes a layering of a porous part having more than 90% by number of pores whose largest dimension is greater than or equal to 100 μm, and a dense part (2, 20, 200, 2000, 20000) having more than 80% by number of pores whose largest dimension is less than 50 μm. The invention is useful in the field of bone regeneration, particularly in the field of bone tissue engineering.

Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.

The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene (“UHMWPE”) blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPE material and vitamin E prior to irradiating the UHMWPE blend with electron beam radiation at a sufficient radiation dose rate to induce crosslinking. The crosslinked UHMWPE blend may be incorporated into a variety of implants, and in particular, into endoprosthetic joint replacements

The present invention generally provides implantable articles and methods of forming implantable articles from a crosslinked ultrahigh molecular weight polyethylene (“UHMWPE”) blend stabilized with Vitamin E. The crosslinked UHMWPE blend may be prepared by combining the UHMWPE material and vitamin E prior to irradiating the UHMWPE blend with electron beam radiation at a sufficient radiation dose rate to induce crosslinking. The crosslinked UHMWPE blend may be incorporated into a variety of implants, and in particular, into endoprosthetic joint replacements

The present description relates to a polymer composition for use in repairing tissue of a patient comprising at least one blood component, as polymer, such a chitosan, and at least one inorganic salt, such as NaCl, method of the composition and method of preparing the composition.

The present description relates to a polymer composition for use in repairing tissue of a patient comprising at least one blood component, as polymer, such a chitosan, and at least one inorganic salt, such as NaCl, method of the composition and method of preparing the composition.

The present description relates to a polymer composition for use in repairing tissue of a patient comprising at least one blood component, as polymer, such a chitosan, and at least one inorganic salt, such as NaCl, method of the composition and method of preparing the composition.

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.

The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.