A heart valve implant comprising a supporting stent, a heart valve element, and a skirt. The skirt includes or is formed of at least one molded body, wherein the molded body is made of dried treated bacterial cellulose that has a swelling capacity that is greater than untreated bacterial cellulose of the same type.

Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.

Disclosed is a medical device exhibiting superior lubricating property and durability (lubrication retaining property), the medical device comprising a substrate layer, an adhesive layer formed on at least a portion of the substrate layer, comprising a hydrophilic copolymer comprising a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, sulfuric acid group, sulfurous acid group, and salts thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group, and a surface lubricious layer formed on at least a portion of the adhesive layer, comprising a hydrophilic polymer dissolvable in a solvent capable of dissolving or swelling the hydrophilic copolymer. Also disclosed are methods for producing medical devices exhibiting superior lubricating property and durability (lubrication retaining property).

Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acinetobacter lysin polypeptides.

A water disintegratable catheter having a barrier layer disposed on an outer surface and/or inner surface of the catheter wherein the barrier layer comprises a hydrophobic component.

Described are coatings for medical devices and methods of forming same.

A flushable catheter assembly includes a catheter shaft having proximal and distal end portions. The catheter may include a funnel assembly associated with the distal end portion of the catheter shaft and/or an introducer cap assembly associated with the proximal end portion of the catheter shaft. A groove is defined along at least a portion of an outer perimeter of the funnel assembly or introducer cap assembly, with the groove being configured to receive at least a portion of the catheter shaft for wrapping the catheter shaft around the outer perimeter when disposing of the catheter. Instead of (or in addition to) a groove, one or more channels may pass through the funnel assembly to receive a portion of the catheter shaft for securing the catheter shaft to the funnel assembly for disposal. The catheter assembly and/or its individual components may be formed of a water disintegrable material.

The present disclosure relates to methods for preparing a hydrophilic composition including intimately mixing a silicone component including at least one polysiloxane and a polymer component, and to hydrophobic polymer compositions prepared thereby. One aspect of the disclosure provides an article having a major exterior surface, the article comprising an intimate mixture of a silicone component including at least one polysiloxane; and a polymer component including at least one hydrophilic polymer having a water-absorption capacity of at least 50 wt. %; wherein the silicone component and the polymer component are present in the mixture in a dry weight ratio within the range of 99.9:0.1 to 30:70. In certain desirable embodiments as otherwise described herein, the intimate mixture is disposed at an exterior surface of the article, e.g., at the major exterior surface of the article.

The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective amount of a composition comprising: (A) at least one taurinamide derivative, (B) at least one compound selected from the group consisting of biologically acceptable acids and biologically acceptable salts thereof; and (C) heparin at a low concentration.

Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using Acintobacter lysin polypeptides.