The invention relates to a partly resorbable tissue clip for stapling tissue, comprising at least one gripping tooth that grips the tissue, at least one force deflecting element that is equipped with at least one gripping tooth, and at least one spring element that is connected to the at least one force deflecting element; the at least one gripping tooth or a portion of the at least one force deflecting element or of at least one of the force deflecting elements is made of bioresorbable material.

A device configured for antimicrobial, in particular bacteriostatic or bactericidal, activity, and a method for manufacturing the device. The device includes a device body having a surface. The device body is configured to anchor thermal nanoparticles supporting optical resonance, in particular localized surface plasmon resonance, at its surface. The device body includes thermal nanoparticles supporting optical resonance, in particular localized surface plasmon resonance, bonded to the surface of the device body. The thermal nanoparticles are capable of increasing their temperature by light irradiation in a wavelength range that matches with the wavelength of the optical resonance, in particular localized surface plasmon resonance, of the thermal nanoparticles. The device body also includes an antimicrobial substance that is releasable from the device body.

An antimicrobial surface treatment method comprising the step of contacting a stainless-steel surface with an aqueous dispersion of at least one functional-lipid construct where the lipid moiety is a phosphatidylethanolamine and the functional moiety confers the antimicrobial activity.

A vascular stent, which includes: a stent body including a plurality of ring-shaped units arranged at intervals and a connecting portion connecting all the ring-shaped units into a tubular structure, wherein the tubular structure has a first covered segment and a second covered segment that are provided with membrane, and an exposed segment configured for engaging the first covered segment and the second covered segment. The vascular stent is reliable in installation, which is beneficial to reduce pre-operation and post-operation adjustment work. The stent system can realize the reliable installation of the vascular stent, which is beneficial to improve the quality of the operation and reduce the operation time.

The present invention includes an apparatus and method of making the apparatus that biomedical apparatus comprises a device adapted for use in a biomedical application that comprises a high entropy alloy comprising at least 5 elements.

An endoprosthesis, in particular an intraluminal endoprosthesis, for example a stent, having a basic mesh composed of an at least predominantly biodegradable material, and a coating provided on the biodegradable material is proposed. For better control of the degradation the basic mesh is essentially completely covered by a coating which contains parylene, preferably at least predominantly parylene, particularly preferably parylene C or parylene N, and the basic mesh is essentially completely covered by the coating, whereby the thickness of the coating is between approximately 0.1 μm and approximately 10 μm, preferably between approximately 0.4 μm and approximately 7 μm, particularly preferably between approximately 1 μm and approximately 5 μm. Also proposed is a method for manufacturing such an endoprosthesis.

An isolated peptide is disclosed. The peptide comprises a titanium oxide binding amino acid sequence connected to a heterologous biologically active amino acid sequence via a beta sheet breaker linker, wherein: (i) the titanium oxide binding amino acid sequence is selected to bind coordinatively with titanium oxide; (ii) the titanium oxide binding amino acid sequence is selected to induce a beta sheet structure; and (ii) the titanium oxide binding amino acid sequence binds to titanium oxide with a higher affinity than said biologically active amino acid sequence binds to the titanium oxide under physiological conditions. Use of the peptides and titanium devices comprising same are also disclosed.

The invention discloses a Zn—Ga series alloy and a preparation method and application thereof, belonging to the technical field of medical alloys. The Zn—Ga series alloy includes Zn and Ga, and Ga accounts for 0-30 wt % but not including 0. The preparation method is to mix Zn and Ga or Zn, Ga and trace elements, then to obtain a Zn—Ga series alloy by coating paint after smelting or sintering. The mechanical properties of the prepared Zn—Ga series alloy meet the requirements of the strength and toughness of medical implant materials, and it can be degraded in vivo. It has the dual characteristics of biological corrosion degradation and suitable corrosion rate to provide long-term effective mechanical support.

Presented herein are dissolution barriers for use with tissue-stimulating prostheses. As described further below, a tissue-stimulating prosthesis comprises a stimulating assembly including an elongate insulating carrier member and a plurality of electrode contacts disposed along the carrier member. A continuous dissolution barrier is disposed on the surface of the stimulating assembly so as to substantially encapsulate/enclose the plurality of electrode contacts and the carrier member. The continuous dissolution barrier is configured to inhibit in situ dissolution of the plurality of electrode contacts.

Devices are provided which are functionalized to include surface regions having anti-infective agents. Methods are provided for functionalizing various material surfaces to include active surface regions for binding anti-infective agents. Methods are provided by which anti-infective moieties or agents are bonded to functionalized surfaces.