The present disclosure provides an implantable device comprising a substrate capable of capturing an intraocular target molecule and to methods of use thereof.

An apparatus for gas-assisted electrosurgery having a gas-assisted electrosurgical probe comprising a tube and an electrode within said tube, wherein a distal end portion of said electrode extends from an opening at a distal end of said tube and an electrically insulating tip connected to a distal end of said electrode. The electrically insulating tip has a substantially hemispherical distal end portion having a radius r.sub.1 and a proximal portion having a circular cross-section and a central axis of a length l.sub.1, wherein l.sub.1>r.sub.1.

A biocompatible surgical article is provided for cutting biological tissue or implantation in contact therewith. The surgical article has a composition of tungsten carbide—nickel with a percentage of additional metal carbides present. A typical composition in total weight percentages is WC 85 to 95%, Cr.sub.3C.sub.2, Mo.sub.2C, VC each alone or in combination being present from 0 to 2%, and Ni constituting the remainder. The composition is formed to have a mean grain size of between 200 and 800 nm with a particle dispersion index (Pdl) corresponding to (the square of the standard deviation)/(mean grain size) of between 0 and 0.6, and in some embodiments between 0.02 and 0.2.

This disclosure describes engineered tissues having structural components embedded therein and methods of making and using such engineered tissues having structural components embedded therein.

A method of implanting a medical implant includes resecting a long bone along a shaft of the bone so as to form a resected surface and remove a metaphysis of the bone. A tapered bore is reamed through the resected surface of the long bone and into an intramedullary canal thereof. A tapered portion of a stem of a medical implant is fully seated within the tapered bore so as to form a press-fit between the tapered portion of the stem and the long bone and so that a collar disposed at an end of the stem is offset from the resected surface so as to form a gap between the resected surface and the collar.

A combination bioactive silicate (e.g., bioactive glass) medicine carrier and shunt of one embodiment includes a shunt which is a tubular member made of bioactive silicate or glass being adapted to be bioresorbable and water soluble, or fiber bundle, the shunt including an insertion end at a first end. Gaps in the bioactive silicate or gaps in the glass adapted to be bioresorbable and water soluble are served as at least one storage for storing medicines.

The present invention provides an orthopedic implant comprising a continuous reinforced composite filament in a freely predetermined fiber orientation in multiple continuous successive layers, wherein the continuous reinforced composite filament comprises a bioabsorbable polymer matrix and a continuous bioabsorbable reinforcing fiber or fiber bundle, and whereby the continuous bioabsorbable reinforcing fiber or fiber bundle of consecutive layers at least partly intermingles and/or intertwines forming a three dimensionally interlocked continuous fiber structure.

The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device. The pre-filled syringe comprises a container and a needle. The container is filled with a pharmaceutical composition comprising epinephrine, a buffer, and water. The buffer is configured to buffer in a pH range between 3 and 4. The needle is adhered to the container by means of a urethane acrylate or urethane methacrylate acrylic light cure adhesive, which is configured to provide a pull out resistance of the needle relative to the container which is between 30 N to 100 N, preferably between 50 N to 70 N, more preferably greater than 60 N after 90 days exposure to the pharmaceutical composition at 40° C. and 75% relative humidity (RH). In an example, the pharmaceutical composition is for the treatment of an anaphylactic event.

The present application provides biodegradable composite material comprising bioresorbable magnesium or magnesium alloy embedded in bioresorbable glass fiber reinforced polymer matrix, and a bioresorbable implant comprising the composite material. The present application also provides use of the composite material, and methods for preparing the composite material and a medical device of a part thereof.

The present invention disclosed a process to coat the surface of flexible polymeric implant with biocompatible polymer such that the coating does not crack when the implant is subjected to mechanical forces such as tension, torsion or bending while retaining the inherent properties of the coated polymer.