Methods of making consolidated blend(s) of polymeric material(s) with one or more therapeutic agents (such as an antibiotic) are provided, wherein the method comprises the steps of providing a polymeric material, blending the polymeric material with one or more therapeutic agent(s), pelletizing the blended polymeric material, environmentally treating by various approaches the pelletized polymeric material, and consolidating the environmentally treated pellet. Products made by the methods and uses of the products also are provided.

Methods of making consolidated blend(s) of polymeric material(s) with one or more therapeutic agents (such as an antibiotic) are provided, wherein the method comprises the steps of providing a polymeric material, blending the polymeric material with one or more therapeutic agent(s), pelletizing the blended polymeric material, environmentally treating by various approaches the pelletized polymeric material, and consolidating the environmentally treated pellet. Products made by the methods and uses of the products also are provided.

Zwitterionic polymers or biocompatible polymers with improved properties for cell encapsulation, coating of devices, or a combination thereof are described. The biocompatible polymer contains a zwitterionic monomer, a monomer with a reactive side chain, and optionally another hydrophobic monomer or a neutral hydrophilic monomer. The zwitterionic polymers are cross-linked with a cross-linker via covalent bond to form a zwitterionic hydrogel in the presence of cells. Also provided, are methods of making and using the zwitterionic polymers.

A stent-graft comprising a tubular, radially self-expandable, braided structure comprising elongate bioabsorbable filaments, a bioabsorbable adhesive means, and a permanent graft disposed and adhered with the adhesive means to at least a portion of the structure and forming a stent-graft assembly, the permanent graft and the tubular structure are coextensive along at least a portion of the stent-graft.

A stent-graft comprising a tubular, radially self-expandable, braided structure comprising elongate bioabsorbable filaments, a bioabsorbable adhesive means, and a permanent graft disposed and adhered with the adhesive means to at least a portion of the structure and forming a stent-graft assembly, the permanent graft and the tubular structure are coextensive along at least a portion of the stent-graft.

An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapour deposition.

An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapour deposition.

PURPOSE: The present invention provides a polyvinyl chloride resin composition which is superior in heat stability and processability and has less elution from the composition. CONSTITUTION: a polyvinyl chloride resin composition comprising 100 parts by weight of a polyvinyl chloride resin, 10 to 120 parts by weight of di(2-ethylhexyl)terephthalate, and 0.5 to 20 parts by weight of epoxidized vegetable oil having a peroxide number of 5 or less.

Disclosed herein is a unique family of medical implants which are engineered outside of a subject's body into a form which may be manipulated in vivo. The implants comprise a region of at least one weldable material which allows welding of the implant to a polymeric material introduced into the body prior to, together with or after the implant has been positioned.

A thermoset polyisobutylene network polymer includes a polyisobutylene diol residue, a diisocyanate residue, and at least one crosslinking compound residue selected from the group consisting of a residue of a sorbitan ester and a residue of a branched polypropylene oxide polyol.