Stent-graft with bioabsorbable structural support

Abstract

A stent-graft comprising a tubular, radially self-expandable, braided structure comprising elongate bioabsorbable filaments, a bioabsorbable adhesive means, and a permanent graft disposed and adhered with the adhesive means to at least a portion of the structure and forming a stent-graft assembly, the permanent graft and the tubular structure are coextensive along at least a portion of the stent-graft.

Claims

1. A stent-graft comprising: a tubular, radially self-expandable, braided structure comprising elongate bioabsorbable filaments; and a permanent graft disposed and adhered to at least a portion of the bioabsorbable tubular structure; wherein the permanent graft and the bioabsorbable tubular structure are coextensive along at least a portion of the stent-graft and the bioabsorbable tubular structure and the permanent graft are adhered with a bioabsorbable adhesive means or the permanent graft is braided into the bioabsorbable tubular structure.

2. The stent-graft of claim 1, the bioabsorbable filaments comprising at least one member selected from the group consisting of polylactide, polylactide-co-glycolide, polyglycolide, polycaprolactone, polydioxanone and mixtures thereof.

3. The stent-graft of claim 1, the bioabsorbable filaments comprising at least one member selected from the group consisting of polylactide, polylactide-co-glycolide, polyglycolide and mixtures thereof.

4. The stent-graft of claim 1, the permanent graft comprising at least one member selected from the group consisting of polyethylene terephthalate, expanded polytetrafluoroethylene, polycarbonate urethane, polyurethane and mixtures thereof.

5. The stent-graft of claim 1, wherein the bioabsorbable filaments substantially consist of polylactide.

6. The stent-graft of claim 1, wherein the permanent graft includes at least one of expanded polytetrafluoroethylene or polycarbonate urethane.

7. The stent-graft of claim 1, wherein the permanent graft is made of braided, woven, or spray-cast polyethylene terephthalate, polycarbonate urethane or polyurethane fibers.

8. The stent-graft of claim 1, wherein the bioabsorbable filaments substantially consist of polylactide and the permanent graft includes at least one of expanded polytetrafluoroethylene or polycarbonate urethane.

9. The stent-graft of claim 1, wherein the filaments have a tensile strength of from about 276 MPa (40 ksi) to about 827 MPa (120 ksi).

10. The stent-graft of claim 1, wherein the filaments have a tensile modulus of from about 2758 MPa (400,000 psi) to about 13790 MPa (2,000,000 psi).

11. The stent-graft of claim 1, wherein each filament has an average diameter of from about 0.15 mm to about 0.6 mm.

12. The stent-graft of claim 1, wherein the braid of the bioabsorbable tubular structure comprises a helical winding of interwoven bioabsorbable filaments.

13. The stent-graft of claim 1, wherein the bioabsorbable tubular structure of the stent-graft includes 10-36 filaments braided into a tubular mesh configuration.

14. The stent-graft of claim 1, wherein the permanent graft comprises braided or interwoven material formed from fibers, strands, yarns, mono-filaments, or multi-filaments.

15. The stent-graft of claim 14, wherein the permanent graft comprises polyethylene terephthalate, polycarbonate urethane or polyurethane.

16. The stent-graft of claim 1, the permanent graft comprises a film, sheet or tube.

17. The stent-graft of claim 16, wherein the permanent graft comprises polyethylene terephthalate, polycarbonate urethane or polyurethane.

18. The stent-graft of claim 1, wherein the adhesive is applied at only proximal and distal end portions of the coextensive portion.

19. The stent-graft of claim 18, wherein the bioabsorbable tubular structure and the permanent graft are braided and the braid angle of the permanent graft is matched to the tubular structure stent filament crossing angle.

20. The stent-graft of claim 1 wherein the tubular, radially self-expandable, braided structure is annealed.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is an isometric view of a stent-graft illustrating an exposed portion of the braided bioabsorbable filaments;

(2) FIG. 2 is a side view of another embodiment of the stent-graft illustrating the graft disposed on a portion of the braided filaments;

(3) FIGS. 3a-3d are various embodiments of the stent-graft in an unconstrained, radially expanded state taken through 3-3 of FIG. 2 illustrating the graft disposed on the outside of the stent, interbraided or interwoven through the stent filaments, on the inside of the stent, and on both the inside and the outside stent, respectively.

(4) FIG. 3e is a side view of FIG. 3d illustrating the stent-graft;

(5) FIG. 4 is an isometric view of the bioabsorbable structure of the stent-graft;

(6) FIG. 5 is a partial longitudinal cross-sectional view of the bioabsorbable structure of the stent-graft;

(7) FIG. 6 is a side view of a second embodiment of the stent-graft;

(8) FIG. 7 is an end view of the stent-graft shown in FIG. 6;

(9) FIG. 8 is an isometric view of one of the filaments of the bioabsorbable structure;

(10) FIG. 9 is a cross-sectional view of one of the filaments of a bioabsorbable structure;

(11) FIGS. 10a-10f are side views of embodiments of filaments having reservoir portions;

(12) FIG. 11 is a cross-sectional view of a mono-filament strand of a permanent graft;

(13) FIG. 12 is a cross-sectional view of a multi-filament yarn used in forming a permanent graft;

(14) FIG. 13 is a side elevation of a segment of the yarn;

(15) FIGS. 14a-14d are side view of embodiments of permanent grafts;

(16) FIG. 15 is a side view of a stent-graft in an unconstrained, radially expanded state;

(17) FIGS. 16a-16b are enlarged views of embodiments of grafts, showing the interbraiding of several textile strands;

(18) FIGS. 17A-17G schematically illustrate fabrication of a stent-graft;

(19) FIGS. 18A-18F schematically illustrate fabrication of a stent-graft;

(20) FIGS. 19A-19D schematically illustrate fabrication of a stent-graft;

(21) FIGS. 20A-20F schematically illustrate fabrication of a stent-graft;

(22) FIG. 21 illustrates an alternative stent-graft with localized bonding of a bioabsorbable stent and a permanent graft;

(23) FIG. 22 shows a further alternative stent-graft with selectively positioned grafts;

(24) FIGS. 23-26 are side views of the stent-graft function in vivo over time at a treatment site; and

(25) FIG. 27 is a side elevation, partially in, section, showing a stent-graft contained within a deployment device; and

(26) FIG. 28 illustrates a stent-graft mounted on an alternative deployment device.

DETAILED DESCRIPTION OF THE INVENTION

(27) A stent-graft 100 is shown generally in FIG. 1 with a permanent graft (graft) 120 covering substantially all of a bioabsorbable structural support (stent) 110 except an exposed portion which is shown uncovered for illustration purposes. An alternative embodiment of the stent-graft 100 is illustrated generally in FIG. 2 where the filaments 112 are exposed at each end and are not covered by the graft.

(28) The support function of the bioabsorbable stent 110 portion of the stent-graft 100 is temporary while the function of the graft 120 is generally permanent. For example, after bracing the lumen open for a period of time necessary for tissue formation on and within the stent-graft 100, the stent 110 is gradually absorbed and vessel compliance and functional stresses are generally transferred to the new tissue. After implantation, the bioabsorbable stent 110 bioabsorbs over time and the generally compliant graft 120 and natural tissue remain in the vessel at the treatment site and form a composite vessel wall.

(29) The stent 110 is formed from helically wound elongated filaments 112 and is preferably made of a non-toxic bioabsorbable polymer such as PGA, PLA, polycaprolactone, or polydioxanone, and the graft 120 is preferably made of braided or film PET, ePTFE, PCU, or PU.

(30) The graft 120 is made of braided or interwoven material formed from fibers, strands, yarns, mono-filaments, or multi-filaments and is adhered with an adhesive to at least a portion of the stent 110. The graft 120 may also be formed from film, sheet, or tube. The especially preferred materials for the stent-graft 100 are PLLA for the bioabsorbable stent 110 and PET, PCU, or PU for the permanent graft 120.

(31) Reference is made to FIGS. 3a-3e illustrating various embodiments of the stent-graft 100. The graft 120 is preferably disposed on the inside surface of the bioabsorbable stent 110 as shown in FIG. 3c. However, the graft 120 may be attached to the outside of the bioabsorbable stent 110 as shown in FIG. 3a or the graft elements 144, 145 may be interbraided or woven with the stent filaments 112 as, for example, shown in FIG. 3b. Alternatively, the graft 120 may be disposed on the inside surface and the outside surface of the bioabsorbable stent 110 as shown in FIG. 3d. FIG. 3e illustrates the stent-graft 100 with a cut-out showing both interior and exterior grafts 120.

(32) The graft 120 and the stent 110 are adhered together at predetermined overlapping locations using an adhesive 130. The stent-graft 100 may be advantageously used for the treatment of arterial fistulas and aneurysms.

(33) Additional detailed descriptions of the components of the stent-graft 100 and methods of making and use are described in further detail below.

(34) A. The Bioabsorbable Structural Support

(35) Reference is made to FIGS. 4 and 5 showing the bioabsorbable structural support (stent) 110 of the stent-graft 100. Stent 110 is made of a plurality of individually rigid, but, flexible and elastic filaments 112, each of which extends in a helix configuration along a longitudinal center line of the body as a common axis. The filaments 112 define a radially self-expanding body. The sets of filaments 112 are interwoven in an over and under braided configuration intersecting at points such as 114 to form an open mesh or weave construction. The stent 110 maybe made with a first number of filaments 112 having a common direction of winding but axially displaced relative to each other, and crossing a second number of filaments 112 also axially displaced relative to each other but having an opposite direction of winding. FIG. 4 shows a stent 110 made of individual braided strands. FIG. 5 shows a stent 110 made of paired interbraided strands.

(36) For reference and descriptive purposes, a braid becomes a stent 110 after annealing. Annealing of the braid relaxes the stresses in the filaments and sets the shape of the stent 110. The term “braid angle” refers to the included angle between interbraided filaments of the braid in the axial orientation prior to annealing and the term “filament crossing angle” refers to the included angle of the stent after annealing.

(37) The stent 110 may be made into various shapes, for example, as shown in FIGS. 6 and 7 where one end tapers and has a diameter which decreases in size. A tapered filament structure may be utilized as an intravascular filter or occlusion device.

(38) Reference is made to FIG. 8 which shows a portion of a typical filament 112 which makes up a stent 110. Stent 110 is shown in its expanded state when subject to no external loads or stresses. The filaments 112 are resilient, permitting the radial compression of stent 110 into a reduced-radius, extended-length configuration suitable for delivery transluminally to the desired treatment site. FIG. 9 illustrates a cross-sectional view of one embodiment of the bioabsorbable filaments 112. As shown, the filaments 112 are substantially homogeneous in cross section.

(39) As described in greater detail below, at least one and preferably all filaments 112 include one or more commercially available grades of polylactide, poly-L-lactide (PLLA), poly-D-lactide (PDLA), polyglycolide (PGA), polydioxanone, polycaprolactone, polygluconate, polylactic acid-polyethylene oxide copolymers, modified cellulose, collagen, poly(hydroxybutyrate), polyanhydride, polyphosphoester, poly(amino acids), poly(alpha-hydroxy acid) or related copolymers materials.

(40) A bioabsorbable stent is disclosed in U.S. patent application entitled “Bioabsorbable Self-Expanding Stent”, Ser. No. 08/904,467, filed Aug. 1, 1997 (now U.S. Pat. No. 6,245,103). Another bioabsorbable stent is disclosed in U.S. patent application entitled “Bioabsorbable Implantable Endoprosthesis With Reservoir And Method Of Using Same,” Ser. No. 08/905,806, filed Aug. 1, 1997 (now U.S. Pat. No. 5,980,564).

(41) A stent 110 may be made by braiding between 10-36 independent strands of 0.15-0.60 mm diameter bioabsorbable polymeric filament 112 interwoven into helical shape strands on a round bar mandrel of 3-30 mm diameter. One-half of the number of helical strands are wound clockwise and one-half are wound counterclockwise such that each clockwise helical strand is adjacent and interbraided with a counterclockwise strand. The tubular braid is made with strand braid angle of about 120-150 degrees and a pitch angle (angle between a filament and transverse axis of the stent) of about 15-30 degrees while on the braid bar mandrel.

(42) The braid is slid off of the braid bar and onto a 0.2-10 mm smaller diameter annealing bar or tube mandrel. Each end of the braid is pulled or compressed to cause axial extension or compression of the braid on the anneal mandrel, or left free. Each end of the braid is secured on each end of the anneal mandrel to fix the preset axial position of the braid, or left free. The braid is annealed on the anneal mandrel at a temperature between the glass-transition temperature and melting temperature of the bioabsorbable polymer for about 5-120 minutes in air, vacuum, or an inert atmosphere. The stent 110 is cooled on the anneal mandrel to about room temperature, slid off of the anneal mandrel, and cut to a desired length.

(43) In addition to substantially solid and homogenous filaments 112, other embodiments of filaments 112 as shown in FIGS. 10a-10f and having one or more reservoir portions including hollow 22, cavity 32, porous 42 portions, or combinations thereof can be used. The term “reservoir” is referred to as a volume of space internal to the filament outer surface where polymer degradation by-products accumulate. The reservoir may include both internal and external passages, with the external passages opening through an outside wall or end of the filament 112. FIG. 10a illustrates a hollow filament 112 with a center core; FIG. 10b illustrates a filament 112 having at least one cavity with sealed ends; FIG. 10c illustrates a filament 112 having at least one pore (internal or external porosity, or both); FIG. 10d illustrates a multi-lumen filament 112 with a plurality of hollow portions; FIG. 10e illustrates a cross-section of a filament 112 having a plurality of internal pores; FIG. 10f illustrates a filament 112 having a plurality of surface pores. The external pores may connect with internal pores, cavities, or hollow portions. The reservoir portions have a size greater than about 1 micron and have a volume percentage greater than about 10%.

(44) Although degradation occurs throughout the filament 112, the rate of degradation is generally higher at locations having a lower pH as acidic environments catalyze degradation. By-products from degradation such as lactic acid or glycolic acid are stored or accumulate in the reservoir portions which accelerate degradation of the inner surfaces.

(45) Table I describes various preferred reservoir embodiments of filament 112.

(46) TABLE-US-00001 TABLE I % Volume Hollow or Cavity % Volume Hollow Features Type of Reservoir: Solid or Cavity Dimensions axial core (one 65-90 10-35 Ø < 50% of O.D. × lumen tubing) length of filament strand multi-lumen filament 50-90 10-40 Ø < 50% of O.D./# (two or more lumens) of lumens, length of filament strand internal porosity 70-90 10-30 1-20 microns external porosity 80-90 10-20 1-20 microns (surface oriented)

(47) The degradation by-products in the reservoir portions may have an average pH level which decreases over time in vivo. The average pH level in the reservoir may be between about 3 and 7. The endoprosthesis may substantially degrade in vivo in less than 3 years. The filaments may comprise PLLA, PDLA, or combinations thereof and substantially degrade in vivo in from about 1 year to about 2 years. The filaments may comprise polylactide, polyglycolide, or combinations thereof and substantially degrade in vivo in from about 3 months to about 1 year. The filaments may comprise polyglycolide, polygluconate, polydioxanone, or combinations thereof and substantially degrade in vivo in from about 1 week to about 3 months.

(48) The filaments 112 may have an outer surface containing a multitude of empty pores which have an average depth of at least about 0.5 micron. The elongate filament 112 prior to implantation may contain at least one empty internal cavity which does not open to the filament 112 outer surface. The average cavity cross-sectional area is from about 2 to about 40 percent of the average filament 112 cross-sectional area.

(49) Tables II and III show various embodiments of the bioabsorbable stent 110 of the stent-graft 100.

(50) TABLE-US-00002 TABLE II # of Filament Brand Mandrel Braid Angle, PLLA Diameter PDLA Diameter, PLLA/PDLA PGA Diameter, Strands in Stent Diameter, mm Degrees mm mm Diameter, mm mm 10 3-6 120-150 .15-.25 .15-.25 .15-.25 .20-.30 10 3-6 120-150 .20-.30 .20-.30 .20-.30 .25-35 12 3-8 120-150 .20-.30 .20-.30 .20-.30 .25-.35 12 3-8 120-150 .35-.45 .35-.45 .35-.45 .40-.50 15  6-10 120-150 .30-.40 .30-.40 .30-.40 .35-.45 15  6-10 120-150 .35-.45 .35-.45 .35-.45 .40-.50 18  7-12 120-150 .35-.45 .35-.45 .35-.45 .40-.50 18  7-12 120-150 .40-.50 .40-.50 .40-.50 .45-.55 20 3-9 120-150 .20-.30 .20-.30 .20-.30 .25-.35 24  8-12 120-150 .20-.30 .20-.30 .20-.30 .25-.35 24  9-14 120-150 .25-.35 .25-.35 .25-.35 .30-.40 24 12-18 120-150 .30-.40 .30-.40 .30-.40 .35-.45 30 16-26 120-150 .30-.40 .30-.40 .30-.40 .35-.45 36 20-30 120-150 .35-.45 .35-.45 .35-.45 .40-.50 24 14-20 120-150 .35-.45 .35-.45 .35-.45 .40-.50

(51) TABLE-US-00003 TABLE III PGA/ # of Filament Braid PGA/ trimethylene Strands in Mandrel Braid Angle, PGA/PLLA polycaprolactone Polydioxanone carbonate Braid Diameter, mm Degrees Diameter, mm diameter, mm diameter, mm diameter, mm 10 3-6 120-150 .20-.30 .22-.32 .25-.35 .22-.32 10 3-6 120-150 .25-.35 .27-.37 .30-.40 .27-.37 12 3-8 120-150 .25-.35 .27-.37 .30-.40 .27-.37 12 3-8 120-150 .40-.50 .42-.52 .45-.55 .42-.52 15  6-10 120-150 .35-.45 .37-.47 .40-.50 .37-.47 15  6-10 120-150 .40-.50 .42-.52 .45-.55 .42-.52 18  7-12 120-150 .40-.50 .42-.52 .45-.55 .42-.52 18  7-12 120-150 .45-.55 .47-.57 .50-.60 .47-.57 20 3-9 120-150 .25-.35 .27-.37 .30-.40 .27-.37 24  8-12 120-150 .25-.35 .27-.37 .30-.40 .27-.37 24  9-14 120-150 .30-.40 .32-.42 .35-.45 .32-.42 24 12-18 120-150 .35-.45 .37-.47 .40-.50 .37-.47 30 16-26 120-150 .35-.45 .37-.47 .40-.50 .37-.47 36 20-30 120-150 .40-.50 .42-.52 .45-.55 .42-.52 24 14-20 120-150 .40-.50 .42-.52 .45-.55 .42-.52

(52) A separately manufactured and permanent graft 120 is disposed on and adhered to a portion of the stent 110 with an adhesive to form the stent-graft 100 and is discussed in further detail below.

(53) B. The Permanent Graft

(54) The permanent graft 120 generally radially expands and contracts with the bioabsorbable stent 110. Vascular grafts are shown, for example, in U.S. Pat. No. 5,116,360.

(55) Reference is made to FIG. 11 which shows a cross-section of a monofilament strand 144 which makes up a graft 120. Strands can be woven, braided, or knitted into a tubular fabric shape. FIG. 12 shows a cross-section of a multi-filament yarn 145. FIG. 13 shows the yarn 145 of FIG. 12 in a side elevation with a twist orientation. Additionally, the graft 120 may include extruded or drawn tubes, films, or sheets. The graft 120 may include layers to make a composite structure with optimized porosity and mechanical properties. Reference is made to FIGS. 14a-14d showing various embodiments of graft 120. FIG. 14a shows a tubular graft 120, preferably made of PET; FIG. 14b shows a tubular graft 120, preferably made of extruded ePTFE, PCU, or PU; FIG. 14c shows an ePTFE, PCU or PU film or sheet preferably formed in the shape of a tubular graft 120 with a butt joint or overlapping joint 121 as shown in FIG. 14d.

(56) FIG. 15 shows a stent-graft 100 with exposed filament end portions 46 and 48 which are used to facilitate long-term fixation of the stent-graft 100 ends with the vessel wall. FIGS. 16a-b show an exterior layer of stent-graft 100 as a textile sheeting or graft 120, formed of multiple textile strands 42 and interwoven with one another. The textile strands 42 are shown braided in two embodiments in FIGS. 16a and 16b. Other embodiments and patterns may also be used. The textile strands 42 intersect one another to define a braid angle θ in a nominal state. FIGS. 15 and 16 show a filament crossing angle a on stent 110 and a angle θ on graft 120 which bisects a longitudinal axis 38.

(57) Textile strands 42 preferably are multi-filament yarns, although they may be mono-filaments. In either case, the textile strands are finer than the structural strands, and range from about 10 denier to 400 denier. Individual filaments of the multi-filament yarns can range from about 0.25 to about 10 denier.

(58) To form graft 120, the strands or yarns may be interbraided on a mandrel such that they intersect each other and form a braid angle. The number of strands or yarns can range from 20 to 700. The graft 120 is preferably made of PET (Dacron) or polycarbonate urethane (PCU) such as Corethane™, however, other materials may include polypropylene (such as Spectra), polyurethane, HDPE, polyethylene, silicone, PTFE, polyolefins, and ePTFE.

(59) The multi-filament yarns are thermally set in generally the same manner as the bioabsorbable stent 110. After the graft 120 is thermally set, it is removed from the mandrel and washed ultrasonically or by agitation. The graft 120 is then cut to a desired length using a laser, which fuses the ends of the strands to prevent unraveling.

(60) One preferred graft and method of making the same is a braided textile tubular sleeve that is adjustable between a nominal state and a radially-reduced axially-elongated state as described in U.S. patent application entitled “Stent Graft With Braided Polymeric Sleeve”, Ser. No. 08/946,906 filed Oct. 8, 1997 (now U.S. Pat. No. 5,957,974) which claims the benefit of U.S. Provisional Application Ser. No. 60/036,160, filed Jan. 23, 1997. A device having a flexible tubular liner is disclosed in U.S. Pat. No. 4,681,110. Several composite braided structures are shown in International Patent Publications Nos. WO 91/10766; WO 92/16166; WO 94/06372; and WO 94/06373. Additional examples are disclosed in U.S. Pat. Nos. 4,475,972; 4,738,740; and 5,653,747. Other examples are disclosed in U.S. patent application Ser. No. 08/640,062 (now U.S. Pat. No. 5,758,562) and Ser. No. 08/640,091 (now U.S. Pat. No. 5,718,159), both filed Apr. 30, 1996 and assigned to the assignee of this application. The graft 120 may be formed of an expandable uniaxially or biaxially oriented polytetrafluoroethylene tube having a microstructure of nodules and fibrils as described in EP 0 775 472 A2.

(61) Table IV illustrates several examples of braided textile fabric grafts having strands with a packing factor of 0.54, and, preferably, a braid angle of about 110 degrees. A coating can be applied to the yarn to enhance surface properties of the yarn and reduce friction.

(62) TABLE-US-00004 TABLE IV Inner # of Yarn Fabric Yarn Fabric Yarn Diameter, Yarn Linear Thickness, Coverage, Porosity, Aspect mm Ends Density inch % % Ratio 6 72 70 .0031 98 55 6.53 6 96 50 .0032 97 58 4.62 6 120 40 .0034 94 62 3.15 6 144 30 .0032 93 64 2.69 12 192 50 .0032 97 58 4.62 24 352 60 .0035 97 58 4.56 40 512 70 .0034 98 56 5.45

(63) Adhesives 130 and methods of manufacturing the stent-graft 100 are discussed in further detail below.

(64) C. Bonding the Graft to the Bioabsorbable Structural Support

(65) A variety of methods and adhesives 130 may be used for bonding the graft 120 to the bioabsorbable structural support 110 are possible. The methods below reference PLLA material, however, other bioabsorbable materials may be used accordingly. A siloxane polymer (silicone) may be used as an adhesive. Other alternative polymers may include fluorosilicone and polycarbonate urethane.

(66) Method 1

(67) A first method includes application of a thermoplastic adhesive to the surface of the PLLA braid by spraying the PLLA braid with a solution of polyurethane or thermoplastic adhesive dissolved in an organic solvent. The graft is disposed over a mandrel and the stent is disposed over the graft. The assembly is heated in an oven at a temperature above the softening temperature of the thermoplastic adhesive and below the melting point of PLLA. The PLLA braid will shrink to the diameter of the mandrel, and make intimate contact with the graft and bond to the graft. The PLLA braid is preferably made such that the braid angle about matches the braid angle of the graft. Adhesives include the polycarbonate urethanes disclosed in U.S. Pat. No. 5,229,431.

(68) Preferred Steps of Method 1

(69) 1. Affix the ends of the stent in a fixture which rotates the stent about its central axis.

(70) 2. Spray the stent with a 7.5% solids solution of 2.5W30 polycarbonate urethane, such as Corethane™, in DMA. Spray using an airbrush with a 7 cc spray-cup. Spray from a distance of 20-25 centimeters (cm) (8-10 inches) from the stent surface, using a reciprocating motion so as to evenly coat the stent surface.

(71) 3. When the spray cup is empty, heat the stent to a temperature above the flashpoint of DMA and below the glass transition temperature of the PLLA. Heat for 5-20 minutes, preferably 10 minutes.

(72) 4. Repeat step 2.

(73) 5. Repeat step 3.

(74) 6. Remove the stent from the fixture and cut off the ends of the stent which were used for gripping and were not sprayed.

(75) 7. Place a section of braided PET graft over a mandrel (For example, place 6 mm diameter graft on a 6 mm mandrel).

(76) 8. Place the sprayed stent over the mandrel and graft.

(77) 9. Affix the ends of the stent to the mandrel, such that the pitch length of the stent matches that of the graft.

(78) 10. Place the mandrel/graft/stent in an oven at 120°-165° C. for 5-120 minutes, preferably 165° C. for 20 minutes.

(79) Method 2

(80) A second method includes braiding extruded PLLA filaments to form a tubular interwoven braid and annealing the braid to the desired braid angle and diameter. Apply a thermoplastic adhesive to the surface of the PLLA mesh. Dispose the braid and graft on a mandrel such that, the graft is on the interior and/or exterior of the braid. Apply radial compression or axial elongation to the composite to create intimate contact between the layers. One preferred method of applying radial compression to the structure uses fluorinated ethylene propylene (FEP) “heat-shrink” tubing which reduces in diameter when heated above its glass transition temperature. Bond the composite layers by heating the structure to a temperature above the glass transition temperature of the heat shrink tubing, and below the melting point of the PLLA filaments.

(81) Preferred Steps of Method 2

(82) 1. Braid the PLLA mesh.

(83) 2. Anneal the mesh to the desired diameter and braid angle by one of the previously described methods.

(84) 3. Affix the ends of the stent in a fixture which rotates the stent about its central axis.

(85) 4. Spray the stent with a 7.5% solids solution of 2.5W30 polycarbonate urethane, such as Corethane™, in DMA. Spray using an airbrush with a 7 cc spray-cup. Spray from a distance of 20-25 cm (8-10 inches) from the stent surface, using a reciprocating motion so as to evenly coat the stent surface.

(86) 5. When the spray-cup is empty, heat the stent to a temperature above the flashpoint of DMA and below the glass transition temperature of the PLLA. Heat for 5-20 minutes, preferably 10 minutes.

(87) 6. Repeat step 4.

(88) 7. Repeat step 5.

(89) 8. Place a graft which has the same braid angle as the stent over or under the stent.

(90) 9. Place the stent and graft over a mandrel which matches the ID of the stent, preferably a fluoropolymer-coated stainless steel mandrel.

(91) 10. Place a piece of FEP heat shrink tubing over the mandrel and stent/graft so that the heat shrink covers the stent and graft.

(92) 11. Heat the assembly in an oven at 120°-165° C. for 5-120 minutes, preferably 165° C. for 20 minutes

(93) 12. Remove the heat shrink from the mandrel, and remove the stent-graft from the mandrel.

(94) Method 3

(95) A third method includes braiding extruded PLLA filaments to form a tubular interwoven braid, and anneal the braid to the desired braid angle and diameter. Apply a coating of curable adhesive to the surface of the braid. Disposing the graft on the interior and/or exterior of the braid such that at least a portion of the graft is in contact with the curable adhesive. Heat the composite at a temperature between the cure temperature of the curable adhesive and the glass transition temperature of the PLLA braid.

(96) Preferred Steps of Method 3

(97) 1. Braid the PLLA filaments into a braid.

(98) 2. Anneal the braid to the desired diameter and braid angle by one of the previously described methods.

(99) 3. Affix the ends of the stent in a fixture which rotates the stent about its central axis.

(100) 4. Spray the stent with a 6% solids solution of silicone such as Applied Silicone 40,000 in THE and xylene. Spray using an airbrush or atomizer. The spray can be applied either to the ends of the stent or to the total stent length. Apply silicone until the desired thickness is obtained.

(101) 5. Apply a stent to the inside and/or outside of the stent so that the graft contacts the silicone adhesive.

(102) 6. Place the stent and graft into an oven at 120°-165° C. for 5-120 minutes, preferably 150° C. for 30 minutes.

(103) Method 4

(104) A fourth method includes braiding extruded PLLA filaments to form a tubular interwoven braid, and annealing the braid to the desired braid angle and diameter. Apply a coating of a bioabsorbable polymer “glue” to the surface of the braid by dissolving poly(d-lactide), PDLA in a solvent such as dimethylformamide (DMF), and spray the solution on to the stent. While the polymer “glue” is tacky, place the graft on the interior and/or exterior of the mesh so that all layers of the composite are in contact. Bond the braid to the graft by heating the structure to a temperature above the flash point of the polymer “glue” solvent and below the glass transition temperature of the PLLA braid. This method may also utilize heat shrink as provided in the second method.

(105) Preferred Steps of Method 4

(106) 1. Braid the PLLA filaments into a braid.

(107) 2. Anneal the braid to the desired diameter and braid angle by one of the previously described methods.

(108) 3. Affix the ends of the stent in a fixture which rotates the stent about its central axis.

(109) 4. Spray the stent with a 7.5% solids solution of PDLA in DMF. Spray using an airbrush or atomizer. The spray can be applied either to the ends of the stent or to the total stent length. Apply PDLA until the desired thickness is obtained.

(110) 5. Apply a stent to the inside and/or outside of the stent so that the graft contacts the silicone adhesive.

(111) 6. Place the stent and graft into an oven at 60°-100° C. for 5-120 minutes, preferably 85° C. for 20 minutes.

(112) Method 5

(113) A fifth method includes braiding extruded PLLA filaments to form a tubular interwoven braid, and annealing the braid to the desired braid angle and diameter. Apply a coating of a bioabsorbable polymer “glue” to the surface of the braid. Placing the graft on the interior and/or exterior of the braid. Bond the braid to the graft by heating the structure to a temperature above the melting point of the polymer “glue” and below the glass transition temperature of the PLLA braid. This method may also utilize heat shrink as provided in the second method.

(114) Preferred Steps of Method 5

(115) 1. Braid the PLLA filaments into a braid.

(116) 2. Anneal the braid to the desired diameter and braid angle by one of the previously described methods.

(117) 3. Affix the ends of the stent in a fixture which rotates the stent about its central axis.

(118) 4. Spray the stent with a 7.5% solids solution of PGA in a solvent. Spray using an airbrush with a 7 cc cup. Spray from a distance of 20-25 cm (8-10 inches) from the stent surface, using a reciprocating motion so as to evenly coat the stent surface.

(119) 5. When the spray-cup is empty, heat the stent to a temperature above the flashpoint of the solvent and below the glass transition temperature of the PGA. Heat for 5-30 minutes, preferably 10 minutes.

(120) 6. Repeat step 4.

(121) 7. Repeat step 5.

(122) 8. Place a graft which has the same braid angle as the stent over or under the stent.

(123) 9. Place the stent and graft over a mandrel which matches the ID of the stent, preferably a fluoropolymer-coated stainless steel mandrel.

(124) 10. Place a piece of FEP heat shrink tubing over the mandrel and stent/graft so that the heat shrink covers the stent and graft.

(125) 11. Heat the assembly in an oven at 120°-165° C. for 5-120 minutes, preferably 165° C. for 20 minutes.

(126) 12. Remove the heat shrink from the mandrel, and remove the stent-graft from the mandrel.

(127) D. Methods of Making a Stent-Graft

(128) A first method is shown in FIGS. 17A-17G. The steps include providing extruded PLLA filament as shown in FIG. 17A. FIG. 17B shows braiding of extruded filaments to form a tubular interwoven braid. FIG. 17C shows the braid off the mandrel with a braid angle from about 120 to 150 degrees and a diameter of about 11 mm. FIG. 17D shows a straight tubular anneal mandrel, preferably with about a 9 mm diameter. FIG. 17E shows the braid being axially compressed in the anneal mandrel to a diameter of about 11.5 mm. The braid is annealed at a temperature between the glass transition temperature and melting point of the bioabsorbable PLLA filament for 15 minutes in a recirculating air oven. The braid will shrink onto the surface of the mandrel during the annealing cycle. The braid can be designed to shrink to a desired diameter and desired filament crossing angle. FIG. 17F shows the annealed stent off the anneal mandrel with a filament crossing angle from about 130 to 150 degrees. As shown in FIG. 17G, the graft is adhered to the annealed stent using a bioabsorbable adhesive while matching within about plus or minus 5° of the graft braid angle to the annealed stent filament crossing angle.

(129) A second method is shown in FIGS. 18A-18F. The steps include providing extruded PLLA filament as shown in FIG. 18A. FIG. 18B shows braiding of extruded filaments to form a tubular interwoven braid. FIG. 18C shows the braid off the mandrel with a braid angle from about 120 to 150 degrees and a diameter of about 11 mm. FIG. 18D shows a straight tubular anneal mandrel, preferably with about a 9 mm diameter. FIG. 18E shows the braid and graft being axially compressed in the anneal mandrel to a diameter of about 11.5 mm and being adhered together using a bioabsorbable adhesive while matching within about plus or minus 5° of the graft braid angle to about the braid angle. The braid-graft is annealed at a temperature between the glass transition temperature and melting point of the bioabsorbable PLLA filament for 15 minutes in a recirculating air oven. The braid-graft will shrink onto the surface of the mandrel during the annealing cycle. The braid-graft can be designed to shrink to a desired diameter and filament crossing angle. FIG. 18F shows the annealed stent-graft off the anneal mandrel with a filament crossing angle from about 130 to 150 degrees.

(130) A third method is shown in FIGS. 19A-19D. The steps include providing extruded PLLA filament as shown in FIG. 19A and annealing unconstrained PLLA filaments at a temperature between the glass transition temperature and the melting point for 15 minutes in a recirculating air oven. FIG. 19B shows braiding of extruded annealed filaments to form a tubular interwoven braid. FIG. 19C shows the stent off the mandrel with a filament crossing angle from about 120 to 150 degrees and a diameter of about 10 mm. FIG. 19D shows the stent and graft being adhered together using a bioabsorbable adhesive while matching within about ±5° the graft braid angle to about the filament crossing angle.

(131) A fourth method is shown in FIGS. 20A-20F. The steps include providing extruded PLLA filament and graft fiber as shown in FIG. 20A. FIG. 20B shows co-braiding of extruded filaments and graft to form a tubular interwoven braid-graft. FIG. 20C shows the braid-graft off the mandrel with a braid angle from about 120 to 150 degrees and a diameter of about 11 mm. FIG. 20D shows a straight tubular anneal mandrel, preferably with about a 9 mm diameter. FIG. 20E shows the braid-graft being axially compressed on the anneal mandrel to a diameter of about 11.5 mm. FIG. 20F shows the braid-graft is annealed at a temperature between the glass transition temperature and melting point of the bioabsorbable PLLA filament for 15 minutes in a recirculating air oven. The braid-graft will shrink onto the surface of the mandrel during the annealing cycle. The braid-graft can be designed to shrink to a desired diameter and filament crossing angle. The annealed stent-graft is removed from the anneal mandrel with a filament crossing angle from about 130 to 150 degrees and a diameter of about 10 mm. The interbraiding of PLLA filaments and graft material forms an interwoven tubular mesh with a desired porosity.

(132) E. Stent-Grafts

(133) The graft 120 may surround the outside surface of stent 110 or the stent 110 may surround the outside surface of graft 120. In another embodiment, two grafts 120 may be used to surround and sandwich the stent 110. The filament crossing angle of the assembly generally determines the relationship between radial compression and axial elongation of the stent-graft 100. Smaller angles generally result in less axial shortening for a given amount of radial enlargement. The graft 120 is highly compliant and conforms to changes in the shape of the stent 110.

(134) A primary consideration is to select a braid angle 0 of the graft 120 with respect to a braid angle a of the stent 110, and to closely match the geometrical diameter and elongation properties of the stent 110 and graft 120 formed into the stent-graft 100 by about matching the respective braid angles.

(135) FIG. 21 shows a stent-graft 100 with portions of exposed ends 100A and 100B of the stent 110 coated with adhesive 130. Bond regions 120A and 120B have axial lengths, preferably of about 17 mm, where the stent 110 and graft 120 are coated with adhesive 130 and bonded together. Over a medial region 120C, the graft 120 and stent 110 are adjacent one another and in surface contact, but not bonded.

(136) FIG. 22 shows a stent-graft 100 with a stent 110 surrounded by proximal and distal grafts 120. The stent 110 is exposed at stent-graft end portions 110A, 110B. Each of the grafts 120 is positionable along an intraluminal location where shunting of the blood flow is desired.

(137) An exposed medial region 110C between grafts 120 is positionable in alignment with a branch of the vessel being treated, so that stent-graft 100 can provide the intended shunting without blocking flow between the main vessel and the branch between the two shunting areas.

(138) FIG. 23 shows an artery lumen 150, artery wall 155 and an untreated arterial aneurysm 160. FIGS. 24-26 schematically show the stent-graft 100 as it is intended to function in-vivo at a treatment site, for example, an aneurysm. FIG. 24 shows a stent-graft 100 implanted in a artery lumen 150 and within or over an aneurysm 160. FIG. 25 shows healing occurring around the stent-graft 100 with exclusion of the aneurysm 160. FIG. 26 shows the bioabsorbable stent 110 has absorbed and that the graft 120 remains in the artery lumen 150 and has become incorporated in the artery wall 155.

(139) Stent-graft 100 offers considerable advantages. In particular, the polymers from which it is formed are highly biocompatible and exhibit good resistance to thrombosis and bacteria adhesion.

Example 1

(140) Stent-graft 100 can be fabricated from a stent 110 having 10 filament strands of 0.15-0.25 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.20-0.30 mm diameter PGA, PGA-PLLA copolymer, 022-0.32 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.25-0.35 mm diameter polydioxanone on a 3-6 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 6 French in size.

Example 2

(141) Stent-graft 100 can be fabricated from a stent 110 having 10 filament strands of 0.20-0.30 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.25-0.35 mm diameter PGA, PGA-PLLA copolymer, 0.27-0.37 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.30-0.40 mm diameter polydioxanone on a 3-6 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 8 French in size.

Example 3

(142) Stent-graft 100 can be fabricated from a stent 110 having 12 filament strands of 0.20-0.30 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.25-0.35 mm diameter PGA, PGA-PLLA copolymer, 0.27-0.37 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.30-0.40 mm diameter polydioxanone on a 3-8 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 8 French in size.

Example 4

(143) Stent-graft 100 can be fabricated from a stent 110 having 12 filament strands of 0.35-0.45 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.40-0.50 mm diameter PGA, PGA-PLLA copolymer, 0.42-0.52 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.45-0.55 mm diameter polydioxanone on a 3-8 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 11 French in size.

Example 5

(144) Stent-graft 100 can be fabricated from a stent 110 having 16 filament strands of 0.30-0.40 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.35-0.45 mm diameter PGA, PGA-PLLA copolymer, 0.37-0.47 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.40-0.50 mm diameter polydioxanone on a 6-10 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 9 French in size.

Example 6

(145) Stent-graft 100 can be fabricated from a stent 110 having 16 filament strands of 0.35-0.45 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.40-0.50 mm diameter PGA, PGA-PLLA copolymer, 0.42-0.52 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.45-0.55 mm diameter polydioxanone on a 6-10 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 11 French in size.

Example 7

(146) Stent-graft 100 can be fabricated from a stent 110 having 18 filament strands of 0.35-0.45 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.40-0.50 mm diameter PGA, PGA-PLLA copolymer, 0.42-0.52 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.45-0.55 mm diameter polydioxanone on a 7-12 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 11 French in size.

Example 8

(147) Stent-graft 100 can be fabricated from a stent 110 having 18 filament strands of 0.40-0.50 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.45-0.55 mm diameter PGA, PGA-PLLA copolymer, 0.47-0.57 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.50-0.60 mm diameter polydioxanone on a 7-12 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 13 French in size.

Example 9

(148) Stent-graft 100 can be fabricated from a stent 110 having 20 filament strands of 0.20-0.30 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.25-0.35 mm diameter PGA, PGA-PLLA copolymer, 0.27-0.37 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.30-0.40 mm diameter polydioxanone on a 3-9 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 8 French in size.

Example 10

(149) Stent-graft 100 can be fabricated from a stent 110 having 24 filament strands of 0.20-0.30 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.25-0.35 mm diameter PGA, PGA-PLLA copolymer, 0.27-0.37 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.30-0.40 mm diameter polydioxanone on a 8-12 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 9 French in size.

Example 11

(150) Stent-graft 100 can be fabricated from a stent 110 having 24 filament strands of 0.25-0.35 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.30-0.40 mm diameter PGA, PGA-PLLA copolymer, 0.32-0.42 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.35-0.45 mm diameter polydioxanone on a 9-14 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 11 French in size.

Example 12

(151) Stent-graft 100 can be fabricated from a stent 110 having 24 filament strands of 0.30-0.40 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.35-0.45 mm diameter PGA, PGA-PLLA copolymer, 0.37-0.47 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.40-0.50 mm diameter polydioxanone on a 12-18 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on me braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-3 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 12 French in size.

Example 13

(152) Stent-graft 100 can be fabricated from a stent 110 having 30 filament strands of 0.30-0.40 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.35-0.45 mm diameter PGA, PGA-PLLA copolymer, 0.37-0.47 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.40-0.50 mm diameter polydioxanone on a 16-26 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-6 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 15 French in size.

Example 14

(153) Stent-graft 100 can be fabricated from a stent 110 having 36 filament strands of 0.35-0.45 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.40-0.50 mm diameter PGA, PGA-PLLA copolymer, 0.42-0.52 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.45-0.55 mm diameter polydioxanone on a 20-30 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-6 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 19 French in size.

Example 15

(154) Stent-graft 100 can be fabricated from a stent 110 having 24 filament strands of 0.35-0.45 mm diameter PLLA, PDLA, PLLA-PDLA copolymer, 0.40-0.50 mm diameter PGA, PGA-PLLA copolymer, 0.42-0.52 mm diameter PGA-polycaprolactone copolymer, PGA-trimethylcarbonate copolymer, or 0.45-0.55 mm diameter polydioxanone on a 14-20 mm diameter braid mandrel with a filament braid angle of 120-150 degrees while the braid is on the braid mandrel. The braid is annealed on a bar or tube mandrel that has an outer diameter 0.2-6 mm smaller than the braid mandrel diameter at a temperature between the polymer glass-transition temperature and the melting temperature for 5-120 minutes in air, vacuum, or inert atmosphere with the braid in an axially extended, free, or contracted position. The stent is cooled to about room temperature, slid off the anneal mandrel, cut to the desired stent length, and adhered to a graft 120 made of one of PET, ePTFE, PCU, or PU. The stent-graft 100 may be loaded onto a delivery system at least 15 French in size.

(155) Tables V-VIII show various embodiments of stent-graft 100.

(156) TABLE-US-00005 Annealed Stent Grant Braid Bioabsorbable Bioabsorbable Anneal Annealed Filament Braid Graft Mandrel Bioabsorbable Filament Braid Mandrel Stent Crossing mandrel Strands Graft Braid Dia., Strands Dia., Angle, Dia., I.D., Angle, Dia., in Graft Yarn Angle, mm in Braid mm Deg. mm mm Deg. mm Braid Denier Deg. 8 24 0.25 130-135 6 6.0 105-115 6.5 120 40 105-115 10 24 0.25 130-135 7 7.0 105-115 7.5 120 50 105-115 10 24 0.25 130-135 8 8.0 105-115 8.5 120 50 105-115 12 24 0.25 130-135 9 9.0 105-115 9.5 120 60 105-115 12.5 24 0.25 130-135 10 10.0 105-115 10.5 192 40 105-115 14 24 0.30 130-135 12 12.0 105-115 12.5 192 50 105-115 22 36 0.35 130-135 20 20.0 105-115 20.5 352 40 105-115 25.8 36 0.40 130-135 22 22.0 105-115 22.5 352 50 105-115 28 36 0.40 130-135 24 24.0 105-115 24.5 352 50 105-115

(157) TABLE-US-00006 TABLE VI Annealed Stent Grant Braid Bioabsorbable Bioabsorbable Anneal Annealed Filament Braid Graft Mandrel Bioabsorbable Filament Braid Mandrel Stent Crossing mandrel Strands Graft Braid Dia., Strands Dia., Angle, Dia., I.D., Angle, Dia., in Graft Yarn Angle, mm in Braid mm Deg. mm mm Deg. mm Braid Denier Deg. 8 24 0.25 105-115 6 6.0 105-115 6.5 120 40 105-115 10 24 0.25 105-115 7 7.0 105-115 7.5 120 50 105-115 10 24 0.25 105-115 8 8.0 105-115 8.5 120 50 105-115 12 24 0.25 105-115 9 9.0 105-115 9.5 120 60 105-115 12.5 24 0.25 105-115 10 10.0 105-115 10.5 192 40 105-115 14 24 0.30 105-115 12 12.0 105-115 12.5 192 50 105-115 22 36 0.35 105-115 20 20.0 105-115 20.5 352 40 105-115 25.8 36 0.40 105-115 22 22.0 105-115 22.5 352 50 105-115 28 36 0.40 105-115 24 24.0 105-115 24.5 352 50 105-115

(158) TABLE-US-00007 TABLE VII Graft Graft Braid Bioabsorbable Bioabsorbable Bioabsorbable Braid Strands in Graft Braid Mandrel Strands in Filament Dia., Braid Angle, Mandrel Graft Yam Angle, Dis., mm Braid mm Degrees Dia., mm Braid Denier Degrees 6 24 0.25 105-115 6.5 120 40 105-115 7 24 0.25 105-115 7.5 120 50 105-115 8 24 0.25 105-115 8.5 120 50 105-115 9 24 0.25 105-115 9.5 120 60 105-115 10 24 0.25 105-115 10.5 192 40 105-115 12 24 0.30 105-115 12.5 192 50 105-115 20 36 0.35 105-115 20.5 352 40 105-115 22 36 0.40 105-115 22.5 352 50 105-115 24 36 0.40 105-115 24.5 352 50 105-115

(159) TABLE-US-00008 TABLE VIII Annealed Stent Braid Bioabsorbable Bioabsorbable Graft Anneal Filament Graft Mandrel Bioabsorbable Filament Braid Graft Braid Mandrel Annealed Crossing Braid Dia., Strands Dia., Angle, Yarn Angle, Dia., Stent Angle, Angle, mm in Braid mm Deg. Denier Deg. mm I.D., mm Deg. Deg. 8 24 0.25 130-135 40 130-135 6 6.0 105-115 105-115 10 24 0.25 130-135 50 130-135 7 7.0 105-115 105-115 10 24 0.25 130-135 50 130-135 8 8.0 105-115 105-115 12 24 0.25 130-135 60 130-135 9 9.0 105-115 105-115 12.5 24 0.25 130-135 40 130-135 10 10.0 105-115 105-115 14 24 0.30 130-135 50 130-135 12 12.0 105-115 105-115 22 36 0.35 130-135 40 130-135 20 20.0 105-115 105-115 25.8 36 0.40 130-135 40 130-135 22 22.0 105-115 105-115 28 36 0.40 130-135 50 130-135 24 24.0 105-115 105-115

(160) Another embodiment of the stent-graft 100 includes at least one bioabsorbable-radiopaque marker strand disposed thereon to visualize the position of the stent-graft 100 through fluoroscopy during implantation.

(161) Bioabsorbable markers that may advantageously be used in conjunction with the present invention are disclosed in U.S. patent applications entitled “Radiopaque Markers And Methods Of Using Same”, Ser. No. 08/905,821 (now U.S. Pat. No. 6,340,367) and “Bioabsorbable Marker Having Radiopaque Constituents And Method Of Using Same”, Ser. No. 08/904,951 (now U.S. Pat. No. 6,174,330) both filed Aug. 1, 1997.

(162) A delivery device is used for delivering the stent-graft 100 to a treatment site in a body vessel. Reference is made to FIG. 27 showing a delivery device 140 for delivering a stent-graft 100 to a treatment site within a body lumen which is used to controllably release the stent-graft 100 within the lumen. The delivery device 140 generally includes an elongate and flexible outer catheter 20 constructed of a biocompatible polymer such as polyurethane. A central lumen 22 runs the length of catheter 20. A distal end region 24 of the outer catheter surrounds stent-graft 100. An inner catheter 26 is contained within lumen 22 and runs along the entire length of the outer catheter. At the distal end of inner catheter 26 is a tapered distal tip 28 which extends beyond the outer catheter. Stent-graft 100 surrounds inner catheter 26, confined between the inner and outer catheters. A lumen 30 in the inner catheter can accommodate a flexible guidewire (not shown) tracked by delivery device 140 as it is advanced toward the treatment site.

(163) Stent-graft 100 may be placed on the delivery device 140 in a radially compressed state. Preferred delivery devices are shown in U.S. Pat. Nos. 4,954,126 and 5,026,377. Alternative delivery devices are shown in U.S. Pat. Nos. 5,201,757; 5,484,444; 5,591,172; 5,628,755; and 5,662,703. Suitable materials for use with such delivery devices are described in U.S. patent application Ser. No. 08/833,639, filed Apr. 8, 1997 (now U.S. Pat. No. 6,042,578).

(164) A pusher-type delivery system provides generally greater self-expansion of the stent-graft 100 than a coaxial inner-outer tube-type delivery system. Pushing the proximal end of the stent-graft 100 out the distal end of the delivery system results in more self expansion than when the stent is released by sliding back the outer tube of the catheter delivery system. The preferred delivery system size for stent-graft 100 is the external diameter in French size of about 7-20 French (French size is equivalent to about three times the diameter in mm).

(165) An alternative delivery device is shown in FIG. 28 where a distal end region of a catheter 122 is used to deploy the stent-graft 100. Stent-graft 100 is designed to remain in the axially elongated, radially reduced delivery state as shown, without additional constraining features. An auxiliary forcing feature is required to urge the stent-graft 100, once properly positioned at a treatment site, toward its normal state. For this purpose a dilatation balloon 126 is mounted to catheter 122 and surrounded by the stent-graft 100. The balloon 126, when inflated by the introduction of fluid under pressure through a lumen in catheter 122, radially expands the stent-graft 100.

(166) Although the present invention has been described with reference to preferred embodiments, those skilled in the art will recognize that changes can be made in form and detail without departing from the spirit and scope of the invention.

(167) It will be evident from considerations of the foregoing that the bioabsorbable self-expanding stent-graft 100 may be constructed using a number of methods and materials, in a wide variety of sizes and styles for the greater efficiency and convenience of a user.

(168) The above described embodiments of the invention are merely descriptive of its principles and are not to be considered limiting. Further modifications of the invention herein disclosed will occur to those skilled in the respective arts and all such modifications are deemed to be within the scope of the invention as defined by the following claims.