This invention relates to the design and function of a compressible valve replacement prosthesis, collared or uncollared, which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve.

Disclosed herein is a medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of (a) an isocyanate-bearing material on or covalently bonded to the substrate and (b) a heparin molecule selected from one of the formulae in the claims. The current invention also relates to a method of forming the medical device, which may be useful as heart stent or intravascular stent that is hemocompatible for preventing the formation of blood clots.

A self-expanding wire frame for a pre-configured compressible transcatheter prosthetic cardiovascular valve, a combined inner frame/outer frame support structure for a prosthetic valve, and methods for deploying such a valve for treatment of a patient in need thereof, are disclosed.

An apparatus for in vitro testing of medical device thrombogenicity includes an enclosure; a heating element thermally coupled to the enclosure; and a temperature feedback circuit operably coupled to the heating element and configured to control the heating element to maintain an interior of the enclosure within a preset temperature range. Positive, negative, and intermediate control rods are provided as standards against which to compare a medical device test article. Multiple blood test loops can be established through the enclosure using a common blood supply. The medical device test article can be placed in one of the loops, while the remaining loops can contain controls. Blood can be circulated through the test loops at a flow rate similar to that encountered in vivo, and thrombus formation can be assessed thereafter.

Disclosed and claimed is any one of long-dwelling body lumen apparatus, such as a catheter or stent (c/s), said c/s comprising: at least one lumen fittingly disposed within a tubular member; a scaffold circumferentially disposed around at least one of an outer surface of at least the tubular member; said scaffold radially extending for at least a portion of the length of the at least tubular member. Furthermore, the scaffold comprised of any one of a pattern of interlocking struts with individual well-like reservoirs disposed; each reservoir having a depth sufficient enough to house at least a first agent of any one of a chemical moiety, each of the reservoirs capped to form an enclosure; and wherein a delayed degradation of said cap results in a sudden release of the housed at least first agent. Any number of agents, reservoirs, and cap configurations may be possible.

An anastomosis device for joining a first and second end of a vascular vessel is disclosed that includes a polymer cylinder ending in opposed first and second vascular-retaining ends configured for insertion into the first and second ends of the vascular vessel respectively. Each vascular-retaining end includes a plurality of bristles protruding outward. The device also includes at least one moiety covalently coupled to the surface of the device. The at least one moiety is selected from at least one anti-coagulant, at least one cell-specific binding peptide, and any combination thereof.

A self-expanding wire frame for a pre-configured compressible transcatheter prosthetic cardiovascular valve, a combined inner frame/outer frame support structure for a prosthetic valve, and methods for deploying such a valve for treatment of a patient in need thereof, are disclosed.

Provided is a medical composition capable of imparting biocompatibility to the surface of a medical instrument etc. and application of the medical composition. In an embodiment of the present invention, the medical composition contains a urethane resin, and the urethane resin has urethane bonds in the main chain and a polyoxyethylene structure in the main chain and/or side chains. In another embodiment of the present invention, the urethane resin has a structural unit derived from a polycarbonate polyol and a structural unit derived from an aliphatic isocyanate and also has at least one urea bond.

A minimally invasive pre-cardiogenic heart assist device has been developed. A method of increasing myocardial blood flow using a Subclavian Diastolic Augmentation Device (SDAD) includes grafting a subclavian vein to a first synthetic chamber, the first synthetic chamber located inside of a body of the patient; grafting a subclavian artery to a second synthetic chamber, the second synthetic chamber located inside of the body of the patient; and pumping blood from the first synthetic chamber to the second synthetic chamber with a pump located inside of the body of the patient.

Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.