A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

An artificial lung is provided having a plurality of porous hollow fiber membranes for gas exchange, in which the hollow fiber membranes have outer surfaces, inner surfaces forming lumens, and opening portions through which the outer surfaces communicate with the inner surfaces, any one of the outer surfaces and the inner surfaces is coated with a colloidal solution of an antithrombotic material containing a polymer as a main component, and an average particle size of the colloid is at least 1.5 times a diameter of the opening portions of the hollow fiber membranes. An artificial lung is provided that can effectively suppress leakage of blood plasma components after blood circulation (blood plasma leakage).

A medical instrument includes a first tube body and a second tube body joined to the first tube body by being inserted in the lumen of the first tube body. The second tube body is more rigid than the first tube body. The medical instrument includes a coating layer made of a biocompatible material disposed on the inner peripheral surfaces of the first and second tube bodies. The inner peripheral surface of the second tube body is radially inward of the inner peripheral surface of the first tube body to create a level difference portion. The thickness of the part of the coating layer which coats the level difference portion is larger than the thickness of the level difference portion.

A medical instrument includes a first tube body and a second tube body joined to the first tube body by being inserted in the lumen of the first tube body. The second tube body is more rigid than the first tube body. The medical instrument includes a coating layer made of a biocompatible material disposed on the inner peripheral surfaces of the first and second tube bodies. The inner peripheral surface of the second tube body is radially inward of the inner peripheral surface of the first tube body to create a level difference portion. The thickness of the part of the coating layer which coats the level difference portion is larger than the thickness of the level difference portion.

An antimicrobial article, a cell culture article, an antithrombotic article, or a biopharmaceutical article that can reduce adhesion of proteins, blood components, cells, or bacteria containing a copolymer that contains a polymerized unit (A) represented by CH.sub.2CHOH and a polymerized unit (B) represented by CH.sub.2CX.sub.2, wherein Xs are the same as or different from each other, and are each an alkyl group having a linear, branched, or cyclic structure, and optionally containing an oxygen atom between carbon atoms, an alkoxy group having a linear, branched, or cyclic structure, and optionally containing a hetero atom between carbon atoms, a siloxy group having a carbon number of 3 or greater, an ester group containing an aromatic ring or an alkyl group and having a linear, branched, or cyclic structure, or H, excluding those in which both Xs are H.

An antimicrobial article, a cell culture article, an antithrombotic article, or a biopharmaceutical article that can reduce adhesion of proteins, blood components, cells, or bacteria containing a copolymer that contains a polymerized unit (A) represented by CH.sub.2CHOH and a polymerized unit (B) represented by CH.sub.2CX.sub.2, wherein Xs are the same as or different from each other, and are each an alkyl group having a linear, branched, or cyclic structure, and optionally containing an oxygen atom between carbon atoms, an alkoxy group having a linear, branched, or cyclic structure, and optionally containing a hetero atom between carbon atoms, a siloxy group having a carbon number of 3 or greater, an ester group containing an aromatic ring or an alkyl group and having a linear, branched, or cyclic structure, or H, excluding those in which both Xs are H.

A curable composition contains a predetermined compound containing a substituted or unsubstituted acrylamide group and a substituted or unsubstituted acrylate group, and a predetermined compound containing a (meth)acrylamide group or a betaine monomer.

A curable composition contains a predetermined compound containing a substituted or unsubstituted acrylamide group and a substituted or unsubstituted acrylate group, and a predetermined compound containing a (meth)acrylamide group or a betaine monomer.

An antithrombogenic metallic material includes a metallic material whose surface is coated with a coating material, the coating material containing: a phosphonic acid derivative or a catechol derivative; a polymer containing, as a constituent monomer, a compound selected from the group consisting of alkyleneimines, vinylamines, allylamines, lysine, protamine, and diallyldimethylammonium chloride; and an anionic compound containing a sulfur atom and having anticoagulant activity; the polymer being covalently bound to the phosphonic acid derivative or the catechol derivative, the phosphonic acid derivative or the catechol derivative being bound to the metallic material through a phosphonic acid group or a catechol group thereof, wherein the abundance ratio of nitrogen atoms to the abundance of total atoms as measured by X-ray photoelectron spectroscopy (XPS) on the surface is 4.0 to 13.0 atomic percent.