There is provided inter alia a solid object having a surface comprising a layered coating of cationic and anionic polymer, wherein the outer coating layer is a layer comprising cationic polymer to which is covalently bound an anticoagulant entity; and wherein the anionic polymer is characterized by having (a) a total molecular weight of 20 kDa-650 kDa; and (b) a solution charge density of 4 eq/g.

According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of:

i) treating a surface of the solid object with a cationic polymer;
ii) treating the surface with an anionic polymer;
iii) optionally repeating steps i) and ii) one or more times;
iv) treating the surface with a cationic polymer; and
v) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer; wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa; and (b) a solution charge density of >4 eq/g; and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.

Provided is a medical composition capable of imparting biocompatibility to the surface of a medical instrument etc. and application of the medical composition. In an embodiment of the present invention, the medical composition contains a urethane resin, and the urethane resin has urethane bonds in the main chain and a polyoxyethylene structure in the main chain and/or side chains. In another embodiment of the present invention, the urethane resin has a structural unit derived from a polycarbonate polyol and a structural unit derived from an aliphatic isocyanate and also has at least one urea bond.

Provided is a medical composition capable of imparting biocompatibility to the surface of a medical instrument etc. and application of the medical composition. In an embodiment of the present invention, the medical composition contains a urethane resin, and the urethane resin has urethane bonds in the main chain and a polyoxyethylene structure in the main chain and/or side chains. In another embodiment of the present invention, the urethane resin has a structural unit derived from a polycarbonate polyol and a structural unit derived from an aliphatic isocyanate and also has at least one urea bond.

Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

Various embodiments of the present invention include a cannula coated or compounded with a material to extend the wear time for a patient by reducing inflammation and therefore increasing the time that the cannula may remain inserted, thereby increasing the effectiveness of the drug delivered using the cannula. The material may include a hydrophilic material, an anti-microbial material, an anti-inflammatory material, anti-thrombogenic material, or a combination of any of these materials.

The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide; an amino ester; an aminoacylanilide; an aminoalkyl benzoate; an amino carbonate; an N-phenylamidine compound; an N-aminoalkyl amid; an aminoketone, or combinations and mixtures thereof. In a particular embodiment of the present invention, the local anesthetic is tetracaine or dibucaine.

The special infusion pump for stem cells includes a liquor storage device and an infusion pipe. The inner wall of the liquor storage sac and the infusion pipe is provided with a layer of anionic protective film, to prevent stem cells in physic liquor from adhering to the inner wall of the liquor storage sac and the infusion pipe using mutual repulsion between anions. The infusion method includes: checking an infusion pump for integrity; closing a liquor stop clamp, injecting a mixed liquor of stem cells and medicine; covering a protective cap, opening the liquor stop clamp, closing the liquor stop clamp for use; connecting an external cone joint with a venous cannula, and then opening the liquor stop clamp; steadily placing the liquor storage sac on a horizontal plane using an auxiliary placing device; and after infusion ends, closing the liquor stop clamp, and disconnecting the external cone joint.

According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of: i) treating a surface of the solid object with a cationic polymer; ii) treating the surface with an anionic polymer; iii) optionally repeating steps i) and ii) one or more times; iv) treating the surface with a cationic polymer; and v) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer; wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa; and (b) a solution charge density of >4 ?eq/g; and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.