Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

A method of sanitizing liquid for use in a. medical device, the method comprising the steps of providing a medical device defining a water circuit with a volume of liquid, sensing the temperature of the volume of liquid with a sensor, heating the volume of liquid from an initial temperature to exceed a threshold temperature, maintaining the volume of liquid above the threshold temperature, determining a time-temperature value for the volume of liquid periodically once the threshold temperature has been exceeded, calculating a. cumulative time-temperature value and providing an output signal once the cumulative time-temperature value has reached a level indicative of a sanitizing dose. A medical device and a liquid sanitizer are also disclosed.

Methods and systems for treating a biological fluid with light are disclosed. The methods and systems provide for determining a target light dose for the biological fluid; loading a treatment container holding the biological fluid into an irradiation chamber of an irradiation device comprising: with the treatment container being supported in the irradiation device in between a first array of light sources and first light energy sensors and a second light energy sensor. The first array of light sources is activated, and a first light intensity is measured with the first light energy sensors. A second light intensity is measured with the second light energy sensor, and the first light intensity is compared to the second light intensity to determine an attenuation factor. The attenuation factor is applied to the first light intensity to determine a time to achieve the target light dose, with the first array of multiple light sources being deactivated after the time to achieve the target light dose has elapsed.

The present invention relates, in some embodiments thereof, to devices, systems and methods for establishing a fluid passageway between vessels. In some embodiments, the invention provides a system for the engagement and establishment of fluid passageway between vessels, the system comprises a first and second vessels configured to be coupled to each other wherein at least one of the first and second vessels comprises a piercing member disposed within the vessel in a retracted position wherein the piercing member confined within/adjacent a port or aperture of the vessel, the piercing member configured to pierce through a cover/seal of the vessel at about the time of or following the engagement between the first and second vessels, thereby establishing a fluid transfer between the vessels.

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

Many pneumonia diseases and lung malfunctions can be quickly repaired using an improved lung lavage technique where the patient is rotated in specific 3D orientations to increase the efficiency of the lavage procedure. The process involves filling and emptying the lungs with fluid and rotating the patient makes this process natural and effective. Supplementary, a hydro-pneumatic system facilitates the operations with the patient sustained in various positions such as being immersed in water and having various control mechanisms such as variable pressures, temperatures, and performing assisted breathing. Additionally, immersed devices are implanted that shake-up of alveolar wall and other devices perform ultrasound imaging with a 0.1 mm resolution, a resolution in competition with stereoscopic X-ray. The bio-medical data acquisition system allows physicians to completely assess patient status in real time and guide the treatment to ensure optimum patient care, under quality assurance procedures.

A method of preparing containers for blood-derived products includes filling the blood-derived product containers with the blood-derived product, of virally inactivating the blood-derived product containers, and detecting possible defects in the blood-derived product containers. The viral inactivation is carried out by placing the blood-derived product containers in contact with steam at sub-atmospheric pressure in a chamber adapted for that purpose.

The invention relates to a system and method to sanitize a fluid while it is moving through a distribution system. The invention provides significant improvements in efficacy and reductions in cost over previous approaches. At least one embodiment of the invention is applicable to commercial, industrial, military, government, public and private facilities that employ forced-air ventilation systems, especially those with comparatively dense human occupancy. The invention has particular utility in hospitals, health care facilities, manufacturing facilities, offices, apartments and dormitories, military housing, afford and schools, as well as on ships, commercial airliners and in public and private transportation. At least one embodiment of the invention may be used to deliver UV-C to a specific surgical site to sanitize the site to prevent future infection.

An apparatus, system, and method for contacting blood with ozone to kill microorganisms in the blood are described. The method involves injecting microbubbles of ozone containing gas into a flow of blood, preferably at a temperature of less than 12 C. The apparatus includes a blood flow conduit including a blood ozone contacting portion including a porous ozone injector.

A method and system for treating a biological fluid within a container by subjecting the container to light is provided. The system includes a fluid treatment chamber for receiving the container of biological fluid; an agitation assembly for oscillating the container of biological fluid within the fluid treatment chamber including a variable speed motor; one or more light sources in proximity to the fluid treatment chamber; at least one sensor for sensing a condition of the biological fluid in the container; and a programmable controller. The programmable controller is further configured to operate the variable speed motor to oscillate the container of biological fluid within the fluid treatment chamber at an initial oscillation rate; activate the one or more light sources; receive a signal indicative of one or more sensed conditions of the fluid in the container; and vary the speed of the motor to adjust the oscillation rate of the container of biological fluid within the fluid treatment chamber based on the sensed conditions.