Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.

Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.

A fluid processing system including an integrated blood component collection and pathogen inactivation fluid circuit is disclosed.

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

A membrane plate assembly is disclosed for use with a cold atmospheric plasma applicator to expose a medium to plasma beams from the plasma applicator. The membrane plate assembly includes a membrane plate stack configured to receive the plasma beams from the plasma applicator. The membrane plate stack includes a plurality of membrane-covered structures facing each other in a generally parallel arrangement and being spaced apart to define a channel therebetween through which the plasma beams are directed. Each membrane-covered structure includes a structure and a membrane covering outer surfaces of the structure with a gap therebetween through which the medium is flowed.

The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body having a native surface. In a second step, the biopolymer aggregate-free fluid is filtered through at least one suitable virus-retentive membrane.

An apparatus for the treatment of a liquid that includes a chamber having at least one inner surface, the chamber adapted for passage of a fluid therethrough. The chamber is at least 80 percent enclosed. The apparatus also includes an optional ultraviolet-transmissive tube disposed within the chamber and also adapted for the passage of the liquid therethrough. The apparatus further includes an ultraviolet lamp disposed within the chamber and, optionally, within the ultraviolet-transmissive tube. A reflective material is interposed between the chamber and the transmissive tube. The reflective material is adapted so as to reflect at least a portion of light emitted by the ultraviolet lamp, wherein the reflective material is at least 80 percent reflective.

A photonic corpuscular irradiator machine, having an irradiation chamber having an external wall, a top edge, a bottom edge, an internal wall, and a spiral ridge; and an ultraviolet irradiation lamp. A machine assembly has an irradiation chamber housing, a bar code scanner, a control panel, an automatic peristaltic pump, and an intensity dial; and further having first and second blood bags. The external wall and the internal wall define a peripheral channel between them, and the spiral ridge extends within the peripheral channel. Blood from the first blood bag travels through an inlet port and is forced upwardly in a spiral motion along the spiral ridge within the peripheral channel and exits from an outlet port to the second bag. The irradiation bulb within of the cavity irradiates ultraviolet light to the blood within the peripheral channel. The ultraviolet light treats blood containing COVID-19 and/or pathogens.

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.